Opportunity Information: Apply for RFA HD 10 010
Apply for RFA HD 10 010
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Molecular Mechanisms of Adverse Metabolic Drug Effects in Children and Adolescents (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Aug 30, 2010 and posted on Aug 30, 2010.
- Applicants must submit their applications by Nov 30, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education State governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Native American tribal governments (Federally recognized) Private institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity titled "Molecular Mechanisms of Adverse Metabolic Drug Effects in Children and Adolescents (R01)" is a discretionary National Institutes of Health grant announcement (Funding Opportunity Number RFA-HD-10-010) issued through the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Its central goal is to support investigator-initiated research that digs into the underlying molecular biology of harmful metabolic side effects caused by medications used in pediatric populations, specifically children and adolescents. In practical terms, NICHD is looking for projects that move beyond simply documenting side effects and instead explain why they happen at the molecular level, with the long-term aim of improving drug safety and outcomes for young patients.
The scientific emphasis is on adverse metabolic effects, meaning unwanted changes in metabolism linked to drug exposure. While the announcement does not list specific drug classes in the excerpt provided, the intent is clearly aimed at medications prescribed to pediatric patients that can trigger metabolic complications. Applications are expected to identify and elucidate mechanisms, which typically implies work that can connect drug exposure to molecular pathways, cellular responses, genetic or epigenetic factors, signaling cascades, endocrine regulation, or other biologic processes that plausibly lead to clinically relevant metabolic disturbances. Because the topic sits at the intersection of basic biology and pediatric care, the FOA explicitly encourages multidisciplinary collaborations, especially teams that pair basic scientists with physician-scientists. That collaboration focus signals that NICHD values mechanistic rigor along with clinical relevance, such as aligning laboratory findings with pediatric phenotypes, treatment contexts, or patient-derived data.
The mechanism of support is the NIH Research Project Grant (R01), which is the standard NIH award for mature, hypothesis-driven research programs. Projects can request up to five years of support, reflecting an expectation that funded studies may require substantial time to develop models, generate mechanistic data, validate findings, and potentially integrate translational components. Budgets may request up to $250,000 per year in direct costs, and NICHD notes that award sizes and durations may vary depending on the scientific scope. The total planned commitment for this initiative is $2.0 million in total costs in fiscal year 2011, and NICHD anticipated making about five awards. Like most NIH opportunities, the announcement also makes clear that actual awards depend on the availability of funds, even when an institute indicates an intended set-aside.
Eligibility is broad and includes many types of applicant organizations. Eligible applicants include public and private institutions of higher education, state and local governments (including county, city or township, special district governments, and independent school districts), federally recognized and other tribal governments and organizations, public housing/Indian housing authorities, nonprofits both with and without 501(c)(3) status, and for-profit organizations (including small businesses and other for-profits). The eligibility language also explicitly includes a range of mission-serving institutions and community-based entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. Foreign (non-U.S.) entities are listed as eligible as well, along with U.S. territories or possessions and regional organizations, indicating the FOA is not strictly limited to domestic applicants.
From an administrative timeline standpoint, the opportunity was posted and created on August 30, 2010. The original and current closing date was November 30, 2010, and the archive date is December 31, 2010, meaning the specific competition is historical rather than currently open. The CFDA listing associated with the program is 93.865 (Child Health and Human Development Extramural Research). There is no cost-sharing or matching requirement, which is typical for NIH R01 awards and lowers the barrier for institutions that might not be able to contribute matching funds.
Applicants looking for the complete text were directed to the NIH grants page for the full RFA, and the contact provided in the excerpt is the NIH Office of Extramural Research (OER) webmaster for technical access issues and linking problems. Overall, the opportunity is best understood as a targeted NICHD R01 initiative meant to build solid mechanistic science around why certain drugs produce harmful metabolic outcomes in pediatric patients, with an emphasis on multidisciplinary teams capable of connecting molecular findings to real pediatric treatment contexts.
Frequently Asked Questions (FAQ)
What is the title of this funding opportunity?
The funding opportunity is titled "Molecular Mechanisms of Adverse Metabolic Drug Effects in Children and Adolescents (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-HD-10-010.
Which NIH institute is issuing this opportunity?
This opportunity is issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health (NIH).
What type of grant mechanism does this opportunity use?
The mechanism of support is the NIH Research Project Grant (R01).
What is the main goal of this R01 initiative?
The central goal is to support investigator-initiated research that explains the underlying molecular biology of harmful metabolic side effects caused by medications used in pediatric populations, specifically children and adolescents.
What kinds of drug-related problems is NICHD trying to address?
The focus is on adverse metabolic effects, meaning unwanted changes in metabolism linked to drug exposure in children and adolescents. The intent is to understand why these metabolic complications occur at the molecular level, rather than only documenting that they occur.
Does the excerpt list specific drug classes that must be studied?
No. In the information provided, specific drug classes are not listed. The intent is broadly aimed at medications prescribed to pediatric patients that can trigger metabolic complications.
What kinds of research approaches or topics fit the scientific emphasis?
Applications are expected to identify and elucidate molecular mechanisms connecting drug exposure to adverse metabolic outcomes. The description suggests work that can connect exposure to molecular pathways and biologic processes such as cellular responses, genetic or epigenetic factors, signaling cascades, or endocrine regulation, in ways that plausibly lead to clinically relevant metabolic disturbances.
Is this opportunity more about basic science or clinical research?
It is positioned at the intersection of basic biology and pediatric care, with an emphasis on mechanistic rigor and clinical relevance. The FOA encourages work that can align mechanistic findings with pediatric phenotypes, treatment contexts, or patient-derived data.
Are multidisciplinary teams encouraged?
Yes. The FOA explicitly encourages multidisciplinary collaborations, especially teams that pair basic scientists with physician-scientists.
What is the maximum project period (how long can the project last)?
Projects can request up to five years of support.
What is the budget limit for this R01?
Budgets may request up to $250,000 per year in direct costs. NICHD also notes that award sizes and durations may vary depending on the scientific scope.
How much total funding did NICHD plan to commit to this initiative?
The total planned commitment was $2.0 million in total costs in fiscal year 2011.
How many awards did NICHD anticipate making?
NICHD anticipated making about five awards.
Are awards guaranteed if the opportunity states an expected number of awards?
No. The announcement indicates that actual awards depend on the availability of funds.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education; state and local governments (including county, city or township, special district governments, and independent school districts); federally recognized and other tribal governments and organizations; public housing/Indian housing authorities; nonprofits with and without 501(c)(3) status; and for-profit organizations (including small businesses and other for-profits).
Are mission-serving and community-based institutions explicitly included?
Yes. The eligibility language explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. Foreign (non-U.S.) entities are listed as eligible, and the FOA also includes U.S. territories or possessions and regional organizations.
Is cost sharing or matching required?
No. There is no cost-sharing or matching requirement.
When was this opportunity posted?
The opportunity was posted and created on August 30, 2010.
What was the application closing date?
The original and current closing date was November 30, 2010.
Is this funding opportunity currently open?
No. The archive date is December 31, 2010, indicating this specific competition is historical rather than currently open.
What CFDA number is associated with this program?
The associated CFDA listing is 93.865 (Child Health and Human Development Extramural Research).
Where were applicants directed to find the full text of the announcement?
Applicants were directed to the NIH grants page for the full Request for Applications (RFA).
Who is listed as the contact in the provided excerpt?
The contact provided is the NIH Office of Extramural Research (OER) webmaster, specifically for technical access issues and linking problems.
What kind of work does NICHD appear to be prioritizing, based on the description?
NICHD appears to be prioritizing projects that move beyond reporting metabolic side effects and instead explain the molecular reasons those effects occur, with an emphasis on research that can ultimately improve drug safety and outcomes for children and adolescents.
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