Opportunity Information: Apply for RFA AG 13 007
Apply for RFA AG 13 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Molecular Mechanisms of Circadian Clocks in Aging Tissues (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Aug 16, 2012 and posted on Aug 16, 2012.
- Applicants must submit their applications by Nov 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: County governments Small businesses City or township governments Independent school districts State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Special district governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Molecular Mechanisms of Circadian Clocks in Aging Tissues (R01) opportunity (Funding Opportunity Number RFA-AG-13-007) is a discretionary research grant issued by the National Institute on Aging (NIA) at the National Institutes of Health (NIH). It was designed to support research that clarifies how circadian clocks are regulated at the molecular level in aging tissues, and how age-related changes in circadian timing systems contribute to altered tissue function and vulnerability to disease. The focus is not only on the central clock in the suprachiasmatic nucleus (SCN), but also on peripheral clocks and other extra-SCN oscillators that operate in individual organs and cell types, which are increasingly recognized as important drivers of metabolic, physiological, and behavioral rhythms across the body.
Scientifically, the FOA emphasizes mechanistic studies that explain what happens to circadian regulation as tissues age. It highlights interest in how disruptions or alterations in the clock system affect chromatin remodeling and other epigenetic processes, changes in gene expression programs over the day-night cycle, regulation of translation, intracellular signaling pathways, and the downstream functional consequences in specific cell populations. In practical terms, this points investigators toward projects that can connect clock machinery to concrete molecular outputs in aged cells, such as shifts in transcriptional rhythms, altered enhancer or promoter accessibility, compromised proteostasis, or rewired signaling networks that might explain diminished tissue resilience with age.
A second major theme is the pathophysiology of circadian clock changes in older tissues. The FOA invites proposals that probe how altered circadian regulation contributes to dysfunction and disease-relevant phenotypes in aging, and it places particular attention on how aging clock systems respond to challenges. Those challenges include metabolic and nutritional stressors (for example, feeding schedules, diet composition, or energetic demands), environmental factors (such as light exposure patterns or other zeitgebers), and pharmacological perturbations (including drug timing, drug responses, or compounds that modulate clock components). The underlying idea is to move beyond descriptive observations and toward causal, experimentally supported models of why circadian control fails or shifts with age and what that means for tissue health.
From an administrative and funding standpoint, this opportunity used the NIH R01 mechanism, supporting investigator-initiated research projects within the scope of the announcement. The estimated total funding amount listed for the FOA was $1,500,000, with an award ceiling of $200,000. There was no cost sharing or matching requirement. The program was posted on August 16, 2012, with an original and current closing date of November 7, 2012, and an archive date of December 8, 2012, indicating it is no longer open but remains relevant as a record of NIA priorities in this area during that cycle.
Eligibility for applicants was broad and included many types of domestic institutions and organizations, such as federal, state, local, and tribal governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (with distinctions noted for institutions of higher education); for-profit organizations (including small businesses and other for-profits); public housing authorities; and special district governments. The eligibility list also explicitly included a range of mission-focused and underrepresented-serving institutions and groups, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, and U.S. territories or possessions. Notably, the FOA also allowed non-U.S. entities (foreign organizations) and regional organizations, reflecting an openness to international participation when scientifically justified.
For additional official details, the announcement referenced the NIH Grants Guide link (http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-13-007.html). The contact information provided was oriented toward technical access and linking issues, directing applicants to the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV) for help accessing the full announcement or resolving connection problems.
FAQs: Molecular Mechanisms of Circadian Clocks in Aging Tissues (R01) - RFA-AG-13-007
What is this funding opportunity?
This is a discretionary research grant opportunity titled Molecular Mechanisms of Circadian Clocks in Aging Tissues (R01), offered under Funding Opportunity Number RFA-AG-13-007. It was issued by the National Institute on Aging (NIA) at the National Institutes of Health (NIH) and used the NIH R01 research project grant mechanism.
Who issued the opportunity?
The opportunity was issued by the National Institute on Aging (NIA), which is part of the National Institutes of Health (NIH).
What research area does the FOA focus on?
The FOA focused on research clarifying how circadian clocks are regulated at the molecular level in aging tissues, and how age-related changes in circadian timing systems contribute to altered tissue function and increased vulnerability to disease.
Is the FOA only about the brain's central circadian clock?
No. While the FOA acknowledges the central clock in the suprachiasmatic nucleus (SCN), it specifically extends the focus to peripheral clocks and other extra-SCN oscillators in individual organs and cell types, reflecting their role in driving metabolic, physiological, and behavioral rhythms across the body.
What types of studies were emphasized scientifically?
The FOA emphasized mechanistic studies aimed at explaining what happens to circadian regulation as tissues age. It encouraged projects that connect circadian clock machinery to concrete molecular outputs and functional consequences in aged tissues and cell populations.
Which molecular and cellular mechanisms were highlighted as areas of interest?
The FOA highlighted interest in mechanisms including:
- Chromatin remodeling and other epigenetic processes
- Daily (day-night) gene expression program changes
- Regulation of translation
- Intracellular signaling pathways
- Downstream functional consequences in specific cell populations
What examples of concrete molecular outputs in aged cells does the FOA point toward?
In practical terms, the FOA pointed investigators toward projects that could link clock machinery to measurable outputs such as:
- Shifts in transcriptional rhythms
- Altered enhancer or promoter accessibility
- Compromised proteostasis
- Rewired signaling networks that may help explain reduced tissue resilience with age
Was disease relevance part of the FOA's goals?
Yes. A major theme was the pathophysiology of circadian clock changes in older tissues, including how altered circadian regulation contributes to dysfunction and disease-relevant phenotypes in aging.
Did the FOA encourage studies that test responses to stressors or challenges?
Yes. The FOA placed particular attention on how aging circadian clock systems respond to challenges, encouraging research that moves beyond descriptive work toward causal, experimentally supported models.
What kinds of challenges or perturbations were specifically mentioned?
The FOA listed several categories of challenges, including:
- Metabolic and nutritional stressors (for example, feeding schedules, diet composition, energetic demands)
- Environmental factors (such as light exposure patterns or other zeitgebers)
- Pharmacological perturbations (including drug timing, drug responses, or compounds that modulate clock components)
What grant mechanism was used?
This opportunity used the NIH R01 mechanism, supporting investigator-initiated research projects within the scope described in the announcement.
What was the estimated total funding amount?
The FOA listed an estimated total funding amount of $1,500,000.
Was there an award ceiling listed?
Yes. The FOA listed an award ceiling of $200,000.
Was cost sharing or matching required?
No. The FOA stated that there was no cost sharing or matching requirement.
When was the opportunity posted?
The FOA was posted on August 16, 2012.
What were the closing and archive dates?
The FOA had an original and current closing date of November 7, 2012, and an archive date of December 8, 2012.
Is this funding opportunity still open?
No. Based on the closing and archive dates provided, this FOA is no longer open for applications. It remains available as a record of NIA priorities during that cycle.
Who was eligible to apply?
Eligibility was broad and included many types of domestic institutions and organizations, including:
- Federal, state, local, and tribal governments
- Public and private institutions of higher education
- Nonprofit organizations with or without 501(c)(3) status (with distinctions noted for institutions of higher education)
- For-profit organizations (including small businesses and other for-profits)
- Public housing authorities
- Special district governments
Did the eligibility list explicitly include underrepresented-serving or mission-focused organizations?
Yes. The eligibility list explicitly included organizations such as:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Faith-based or community-based organizations
- U.S. territories or possessions
Were foreign (non-U.S.) organizations allowed to apply?
Yes. The FOA allowed non-U.S. entities (foreign organizations) and regional organizations, indicating openness to international participation when scientifically justified.
Where can someone find the official FOA announcement?
The FOA referenced the NIH Grants Guide announcement page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-13-007.html
Who was listed as the contact for help accessing the announcement?
The contact information provided was for technical access and linking issues, directing users to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What type of help was the provided contact intended for?
The provided contact was intended for technical issues, such as help accessing the full announcement or resolving connection/linking problems, rather than scientific or programmatic questions.
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