Opportunity Information: Apply for RFA DK 10 006
Apply for RFA DK 10 006
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Mouse Metabolic Phenotyping Centers Consortium (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Aug 9, 2010 and posted on Aug 9, 2010.
- Applicants must submit their applications by Nov 17, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,310,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $600,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities Small businesses Private institutions of higher education Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) State governments County governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Mouse Metabolic Phenotyping Centers Consortium (U24) opportunity (Funding Opportunity Number RFA-DK-10-006) is a National Institutes of Health (NIH) cooperative agreement led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) with participation from the National Heart, Lung and Blood Institute (NHLBI). Its central goal is to support a small national network of Mouse Metabolic Phenotyping Centers (MMPCs) that operate as fee-for-service resources for the broader research community. These centers are meant to help investigators studying diabetes, obesity, cardiovascular-metabolic conditions, and other related metabolic diseases by providing rigorous, standardized, and specialized phenotyping that many individual labs cannot easily perform on their own.
In practical terms, the MMPCs function like shared national service hubs for deep metabolic characterization of mouse models. Researchers ship live mice and/or relevant tissues to the center, and the center applies standardized procedures to generate high-quality, comparable data across projects and institutions. The phenotyping scope is intentionally broad and in-depth, covering metabolism and energy balance, body composition, feeding behavior, physical activity, tissue pathology, organ function, and other physiologic, anatomic, or pathologic readouts relevant to metabolic disease. The emphasis on standardization is a key feature of the program because it improves reproducibility and allows results from different mouse models and studies to be compared more directly.
This funding uses the U24 mechanism, which is a cooperative agreement. That structure typically signals an active partnership between NIH and the awardees, with NIH having substantial programmatic involvement in how the centers operate as a coordinated consortium. The announcement also notes that this FOA runs in parallel with a related solicitation (RFA-DK-10-007) for a Coordinating and Bioinformatics Unit for the MMPC consortium, indicating that the program is designed to function as an integrated network with centralized coordination and data/bioinformatics support alongside the individual phenotyping centers.
NIH anticipated making four to six awards under this announcement. The estimated total program funding is up to $4,310,000 per year, with the project period spanning five years. Individual awards list an upper range (award ceiling) of $600,000, reflecting the expectation that each center will have sufficient capacity, expertise, and infrastructure to provide national-level phenotyping services while operating within defined budget parameters.
Eligibility is broad and includes many types of domestic and non-domestic organizations, reflecting the NIH-wide approach to allow a wide range of capable entities to compete. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) organizations), for-profit organizations (including small businesses and other for-profits), and various government entities (state, county, city/township, special district governments, and certain housing authorities). The eligibility language also explicitly includes institutions and organizations serving specific populations (for example, HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions), tribal governments and tribal organizations, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and even foreign organizations/non-U.S. entities, as described in the announcement.
Administratively, the opportunity was posted on August 9, 2010, with an original and current closing date of November 17, 2010, and an archive date of December 18, 2010. There is no cost sharing or matching requirement. The program is categorized under NIH’s broader health research areas and includes CFDA listings tied to cardiovascular diseases research (93.837) and diabetes/digestive/kidney diseases extramural research (93.847), reflecting the cross-cutting relevance of metabolic phenotyping to both diabetes/obesity research and heart, lung, and blood-related disease areas.
Overall, this FOA is best understood as NIH’s investment in national-scale research infrastructure: a coordinated set of specialized mouse phenotyping centers that can deliver standardized, high-resolution metabolic and physiologic assessments to accelerate discovery and improve rigor across studies of diabetes, obesity, and related metabolic disorders.
Frequently Asked Questions (FAQs)
What is the Mouse Metabolic Phenotyping Centers Consortium (U24) opportunity?
The Mouse Metabolic Phenotyping Centers Consortium (U24) is an NIH cooperative agreement funding opportunity (Funding Opportunity Number RFA-DK-10-006) designed to support a small, national network of Mouse Metabolic Phenotyping Centers (MMPCs). These centers operate as fee-for-service resources that provide rigorous, standardized, specialized metabolic phenotyping services to the broader research community.
Which NIH institutes lead and participate in this program?
This opportunity is led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), with participation from the National Heart, Lung, and Blood Institute (NHLBI).
What is the main goal of the MMPC consortium?
The central goal is to maintain national-level service hubs that can perform deep, standardized metabolic characterization of mouse models in ways that many individual laboratories cannot easily do on their own. The intent is to accelerate and strengthen research on diabetes, obesity, cardiovascular-metabolic conditions, and related metabolic diseases.
What do MMPCs do in practical terms?
MMPCs function as shared service centers. Investigators ship live mice and/or relevant tissues to an MMPC, and the center performs standardized phenotyping procedures to generate high-quality data that can be compared across projects and institutions.
Is this program intended to be a national resource?
Yes. The centers are described as a small national network designed to serve the broader research community on a fee-for-service basis.
What types of research does this program support?
The program supports research that benefits from specialized mouse metabolic and physiologic phenotyping, particularly studies focused on diabetes, obesity, cardiovascular-metabolic conditions, and other metabolic diseases where rigorous, standardized phenotyping improves interpretability and reproducibility.
What kinds of phenotyping are included in the MMPC scope?
The phenotyping scope is broad and in-depth. It includes metabolism and energy balance, body composition, feeding behavior, physical activity, tissue pathology, organ function, and other physiologic, anatomic, or pathologic readouts relevant to metabolic disease.
Why is standardization emphasized in this FOA?
Standardization is highlighted as a key feature because it improves reproducibility and helps ensure that data generated from different mouse models, investigators, and institutions can be compared more directly.
What does the U24 mechanism mean for applicants and awardees?
The U24 is a cooperative agreement, which generally indicates an active partnership between NIH and the awardees. In this structure, NIH typically has substantial programmatic involvement in how the centers operate as a coordinated consortium.
Is there a coordinating or bioinformatics component associated with this program?
Yes. The announcement notes that this FOA runs in parallel with a related solicitation (RFA-DK-10-007) for a Coordinating and Bioinformatics Unit, indicating that the MMPC program is intended to operate as an integrated network with centralized coordination and data/bioinformatics support alongside the phenotyping centers.
How many awards did NIH anticipate making under this announcement?
NIH anticipated making four to six awards under RFA-DK-10-006.
What is the total expected program funding level?
The estimated total program funding is up to $4,310,000 per year.
How long is the project period?
The project period spans five years.
Is there an award ceiling for individual awards?
Yes. Individual awards list an upper range (award ceiling) of $600,000.
What is the expected role of each funded center given the budget parameters?
Based on the description, each center is expected to have sufficient capacity, expertise, and infrastructure to provide national-level phenotyping services while operating within defined budget parameters.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education; nonprofits (including 501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses and other for-profits); and various government entities such as state, county, city/township, and special district governments, as well as certain housing authorities.
Are organizations that serve specific populations explicitly included in eligibility?
Yes. The eligibility language explicitly includes organizations such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and other similar entities described in the announcement.
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations are explicitly included in the eligibility description.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The eligibility language explicitly includes foreign organizations/non-U.S. entities, as described in the announcement.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
When was this funding opportunity posted?
The opportunity was posted on August 9, 2010.
What was the closing date for applications?
The original and current closing date listed is November 17, 2010.
When was the opportunity archived?
The archive date is December 18, 2010.
How is this program categorized within NIH and what CFDA listings are referenced?
The program is categorized under NIH health research areas and includes CFDA listings tied to cardiovascular diseases research (93.837) and diabetes/digestive/kidney diseases extramural research (93.847), reflecting the cross-cutting relevance of metabolic phenotyping.
How should this FOA be understood at a high level?
This FOA is best understood as an NIH investment in national-scale research infrastructure: a coordinated set of specialized mouse phenotyping centers that deliver standardized, high-resolution metabolic and physiologic assessments to accelerate discovery and improve rigor across studies of diabetes, obesity, and related metabolic disorders.
Are the MMPCs described as fee-for-service?
Yes. The centers are intended to operate as fee-for-service resources for the broader research community.
What materials do investigators send to an MMPC for phenotyping?
According to the description, researchers ship live mice and/or relevant tissues to the center for standardized phenotyping.
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| Collaborative Studies on The Central Nervous System and Glycemia (R01) Apply for PAS 11 029 Funding Number: PAS 11 029 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| NIDDK Program Project Applications (P01) Apply for PAR 11 043 Funding Number: PAR 11 043 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
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| NIDDK Short Term Education Program for Underrepresented Persons (STEP UP) (R25) Apply for RFA DK 11 011 Funding Number: RFA DK 11 011 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
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