Opportunity Information: Apply for RFA AR 13 001
Apply for RFA AR 13 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Multidisciplinary Clinical Research Centers (P60)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846 Arthritis, Musculoskeletal and Skin Diseases Research.
- This funding opportunity was created on Jan 10, 2012 and posted on Jan 10, 2012.
- Applicants must submit their applications by May 18, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,600,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $800,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) State governments Independent school districts Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Multidisciplinary Clinical Research Centers (MCRC) program (P60) is a NIAMS-supported center grant opportunity designed to strengthen and coordinate clinical research in arthritis, musculoskeletal disorders, and skin diseases. NIAMS is looking for applications that bring together multiple disciplines in a structured center model, with the goal of tackling important patient-focused questions within the NIAMS mission. The emphasis is on building a cohesive research center that can support and accelerate high-quality clinical research by providing shared resources, expertise, and a unifying methodological approach.
A defining feature of this opportunity is that every center must be organized around a single methodology core that serves as the hub of the MCRC. This core is not an optional add-on; it is the foundation of the center and is expected to provide the essential support needed to develop and carry out the center's clinical projects. In practical terms, this typically means the core would provide specialized methods and infrastructure such as clinical epidemiology, biostatistics, outcomes research methods, imaging or biomarker standardization, informatics, patient-reported outcome measurement, recruitment and retention strategies, or other cross-cutting clinical research capabilities. The core should enable consistency, rigor, and efficiency across projects and help the center produce results that are broadly useful to the field.
In addition to the methodology core, each application must include at least two highly meritorious clinical projects. These projects must be clearly focused on diseases or conditions that fall within NIAMS-supported scientific areas. NIAMS also signals what kind of clinical research it wants these projects to represent: each project must address a critical issue that directly involves prevention, assessment, and/or outcomes for patients with chronic NIAMS-relevant conditions. That framing points toward studies that improve how conditions are prevented, detected, characterized, measured, and managed in real-world patient contexts, including work that refines outcome measures, evaluates predictors of prognosis, develops or validates assessment tools, or improves understanding of patient-centered outcomes. While the projects are clinical in nature, the announcement is explicit that clinical trials will not be supported under this funding mechanism, so applicants would need to design projects that are clinical research but not interventional clinical trials as defined by NIH policy.
NIAMS expects MCRCs to be built on an already strong, meritorious research base, rather than serving as a way to create a program from scratch. Centers are also expected to leverage existing institutional infrastructure resources, meaning the applicant organization should demonstrate that it has a supportive environment and can efficiently integrate the P60 support with established facilities, clinical populations, research administration, and other relevant institutional assets. The overall intent is to create centers that can deliver more than the sum of individual projects by sharing methods, harmonizing approaches, and creating sustained capacity for impactful clinical research in NIAMS mission areas.
From an administrative standpoint, this is a discretionary NIH grant opportunity with the funding opportunity number RFA-AR-13-001 and CFDA number 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research). NIAMS estimated total funding for the opportunity at $3.6 million, with an award ceiling of $800,000. The posting and creation date were January 10, 2012, with an original and current closing date of May 18, 2012, and an archive date of June 18, 2012. Cost sharing or matching is not required.
Eligibility is broad across U.S.-based organizations and includes public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, other than higher education institutions), small businesses, for-profit organizations other than small businesses, and a range of government entities (state, county, city/township, special district, independent school districts, and public housing authorities/Indian housing authorities). Tribal governments and tribal organizations are included, along with a variety of mission-focused institutional categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. However, foreign institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components are not allowed under NIH policy as described in the announcement.
The full announcement is available through the NIH Grants Guide at the provided link, and NIH’s Office of Extramural Research (OER) webmaster contacts are listed for technical access or linking issues.
Frequently Asked Questions (FAQs)
What is the Multidisciplinary Clinical Research Centers (MCRC) program (P60)?
The Multidisciplinary Clinical Research Centers (MCRC) program (P60) is a NIAMS-supported center grant opportunity intended to strengthen and coordinate clinical research in arthritis, musculoskeletal disorders, and skin diseases. It supports a structured center model that brings multiple disciplines together to address important patient-focused questions within the NIAMS mission.
What is NIAMS looking for in an MCRC application?
NIAMS is looking for applications that build a cohesive, multidisciplinary clinical research center. The center should accelerate high-quality clinical research by providing shared resources, shared expertise, and a unifying methodological approach across the center's clinical projects.
What is the defining structural requirement of this MCRC opportunity?
Every MCRC must be organized around a single methodology core that serves as the hub of the center. This methodology core is required and is described as the foundation of the center, providing essential support for developing and carrying out the center's clinical projects.
Is the methodology core optional?
No. The methodology core is not an optional add-on. The opportunity states it is the foundation of the center and is expected to provide essential support needed to develop and carry out the center's clinical projects.
What kinds of activities can the methodology core support?
The methodology core can provide specialized methods and infrastructure that cut across projects. Examples described include clinical epidemiology, biostatistics, outcomes research methods, imaging or biomarker standardization, informatics, patient-reported outcome measurement, recruitment and retention strategies, and other cross-cutting clinical research capabilities.
What is the purpose of having a single methodology core?
The methodology core is intended to enable consistency, rigor, and efficiency across the center's clinical projects. It is also intended to help the center generate results that are broadly useful to the field by harmonizing methods and supporting high-quality clinical research across projects.
How many clinical projects are required in an application?
Each application must include at least two highly meritorious clinical projects in addition to the required single methodology core.
What must the clinical projects focus on?
The clinical projects must be clearly focused on diseases or conditions that fall within NIAMS-supported scientific areas, specifically in the broader domains of arthritis, musculoskeletal disorders, and skin diseases research as described in the opportunity.
What types of patient-focused questions should the clinical projects address?
Each project must address a critical issue that directly involves prevention, assessment, and/or outcomes for patients with chronic NIAMS-relevant conditions. The intent is to support clinical research that improves how conditions are prevented, detected, characterized, measured, and managed in real-world patient contexts.
What are examples of the kinds of clinical research topics NIAMS signals interest in?
The opportunity points toward work that refines outcome measures, evaluates predictors of prognosis, develops or validates assessment tools, or improves understanding of patient-centered outcomes, as long as the projects remain within NIAMS mission areas and align with the prevention/assessment/outcomes framing.
Are clinical trials allowed under this funding mechanism?
No. The announcement is explicit that clinical trials will not be supported under this funding mechanism. Applicants need to propose clinical research projects that are not interventional clinical trials as defined by NIH policy.
Does NIAMS expect applicants to be starting a brand-new program?
No. NIAMS expects MCRCs to be built on an already strong, meritorious research base, rather than serving as a mechanism to create a program from scratch.
Are applicants expected to use existing institutional resources?
Yes. Centers are expected to leverage existing institutional infrastructure resources. The applicant organization should demonstrate a supportive environment and the ability to integrate P60 support efficiently with established facilities, clinical populations, research administration, and other relevant institutional assets.
What is the overall goal of an MCRC as described in this opportunity?
The overall intent is to create centers that deliver more than the sum of individual projects by sharing methods, harmonizing approaches, and creating sustained capacity for impactful clinical research in NIAMS mission areas.
What is the Funding Opportunity Number (FOA) for this grant?
The funding opportunity number is RFA-AR-13-001.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.846, listed as Arthritis, Musculoskeletal and Skin Diseases Research.
What is the estimated total funding for the opportunity?
NIAMS estimated total funding at $3.6 million.
What is the award ceiling?
The award ceiling listed for this opportunity is $800,000.
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
What are the key dates for this opportunity?
The posting and creation date are January 10, 2012. The original and current closing date is May 18, 2012. The archive date is June 18, 2012.
Who is eligible to apply?
Eligibility is broad for U.S.-based organizations and includes public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, other than higher education institutions), small businesses, for-profit organizations other than small businesses, and multiple types of government entities (state, county, city/township, special district, independent school districts, and public housing authorities/Indian housing authorities). Tribal governments and tribal organizations are included, along with categories such as HBCUs, Hispanic-serving institutions, TCCUs, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed under this opportunity?
No. Foreign components are not allowed under NIH policy as described in the announcement.
Where can applicants find the full announcement?
The full announcement is available through the NIH Grants Guide at the link provided in the opportunity information.
Who should be contacted for technical issues accessing or linking to the announcement?
The opportunity lists NIH Office of Extramural Research (OER) webmaster contacts for technical access or linking issues.
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