Opportunity Information: Apply for RFA AR 12 001
Apply for RFA AR 12 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Multidisciplinary Clinical Research Centers (P60)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846 Arthritis, Musculoskeletal and Skin Diseases Research.
- This funding opportunity was created on Mar 25, 2011 and posted on Mar 25, 2011.
- Applicants must submit their applications by Jun 24, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $6,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal governments (Federally recognized) City or township governments For profit organizations other than small businesses Private institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Special district governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Organizations) are not eligible to apply. Foreign (non U.S.) components of U.S. Organizations are not allowed.
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Opportunity Summary:
The Multidisciplinary Clinical Research Centers (MCRC) grant opportunity (P60) is a National Institutes of Health program run by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) to support integrated, team-based clinical research centers focused on arthritis, musculoskeletal disorders, and skin diseases. NIAMS is seeking both new and renewal applications for centers that can bring together multiple disciplines around shared clinical research goals that fit squarely within the NIAMS mission areas. The intent is to fund centers that already have a strong underlying research foundation and can use existing institutional resources to build something larger and more coordinated than a set of unrelated projects.
A defining feature of an MCRC under this announcement is that it must be organized around a methodology core that serves as the hub of the center. This core is not an optional add-on; it is the foundation that provides essential expertise, infrastructure, and support to design and carry out the center's clinical research. In practical terms, the methodology core is meant to strengthen the rigor and consistency of clinical studies by centralizing key capabilities that projects commonly need, such as clinical research methods, measurement and assessment approaches, outcomes and endpoint selection, study operations support, and other cross-cutting methodological functions. The center model is intended to create efficiencies and raise quality by sharing these resources across multiple projects rather than duplicating them in separate labs or departments.
Beyond the methodology core, each MCRC is required to include at least two highly meritorious clinical projects. These projects must focus on diseases or conditions within the NIAMS mission and must address critical clinical issues that directly involve prevention, assessment, and/or patient outcomes for chronic diseases or conditions in the NIAMS portfolio. In other words, the program is oriented toward research that has clear relevance to patients and clinical decision-making, including how conditions are prevented, how they are evaluated or measured in clinical contexts, and how outcomes are improved or understood over time. The requirement for multiple projects also reflects the program's emphasis on multidisciplinary breadth and synergy, where projects benefit from shared methods and a common center structure.
An important limitation of this opportunity is that clinical trials are not supported under this funding mechanism. Applicants need to design their clinical projects accordingly, focusing on clinical research that fits the announcement's scope without proposing clinical trial activities that would fall outside what NIAMS will fund through this P60 mechanism. The overall expectation is that the center will leverage existing institutional infrastructure resources rather than attempting to build everything from scratch, suggesting reviewers will be looking for evidence of strong organizational capacity, established research environments, and feasible plans to integrate with what an institution already has in place.
The total estimated funding listed for the opportunity is $6,000,000. The program does not require cost sharing or matching. The funding instrument is a grant, and the activity category is health (CFDA 93.846: Arthritis, Musculoskeletal and Skin Diseases Research). The announcement was posted March 25, 2011, with an original and current closing date of June 24, 2011, and an archive date of July 25, 2011.
Eligibility is broad across many U.S.-based organization types, including public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, state and local governments (including counties, cities, townships, special districts), independent school districts, public housing authorities/Indian housing authorities, Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments), and other entities as specified. The announcement also explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Non-U.S. entities (foreign organizations) are not eligible to apply, and foreign components of U.S. organizations are not allowed, reinforcing that funded activities must be domestic in scope and implementation.
The full announcement and details are available through the NIH grants page linked in the opportunity, and technical access issues are directed to the NIH Office of Extramural Research (OER) webmaster contacts provided in the notice.
Frequently Asked Questions (FAQs) - Multidisciplinary Clinical Research Centers (MCRC) (P60)
What is the Multidisciplinary Clinical Research Centers (MCRC) (P60) grant opportunity?
The MCRC (P60) is a National Institutes of Health (NIH) program run by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) that supports integrated, team-based clinical research centers focused on arthritis, musculoskeletal disorders, and skin diseases.
Which NIH Institute runs this program?
The program is run by NIAMS (National Institute of Arthritis and Musculoskeletal and Skin Diseases), an institute within NIH.
What is the main purpose of an MCRC center under this announcement?
The purpose is to support coordinated, multidisciplinary clinical research centers that build on an existing strong research foundation and use institutional resources to create something more integrated than a collection of unrelated projects.
Does NIAMS accept new applications, renewal applications, or both?
NIAMS is seeking both new and renewal applications under this opportunity.
What NIAMS mission areas must the center align with?
The center and its projects must fit within NIAMS mission areas: arthritis, musculoskeletal disorders, and skin diseases.
What is the defining structural feature required for an MCRC?
An MCRC must be organized around a methodology core that serves as the hub of the center. This core is required and is not optional.
What is a methodology core in the context of this MCRC opportunity?
The methodology core is the foundation of the center and provides essential expertise, infrastructure, and support to design and conduct the center's clinical research. It centralizes cross-cutting methodological functions that multiple projects commonly need.
What types of support is the methodology core expected to provide?
Based on the announcement description, the methodology core is intended to support capabilities such as clinical research methods, measurement and assessment approaches, outcomes and endpoint selection, study operations support, and other cross-cutting methodological functions that strengthen rigor and consistency across clinical studies.
Why does NIAMS require a shared methodology core?
The center model is meant to create efficiencies and improve quality by sharing key resources across multiple projects rather than duplicating similar capabilities in separate labs, departments, or individual projects.
How many clinical research projects are required in an MCRC application?
Each MCRC is required to include at least two highly meritorious clinical projects.
What focus must the required clinical projects have?
Projects must focus on diseases or conditions within the NIAMS mission and address critical clinical issues that directly involve prevention, assessment, and/or patient outcomes for chronic diseases or conditions in the NIAMS portfolio.
What does "clinical issues" mean in this program context?
In this announcement, the emphasis is on research with clear relevance to patients and clinical decision-making, including how conditions are prevented, how they are evaluated or measured in clinical contexts, and how outcomes are improved or understood over time.
Is the program intended to support unrelated projects grouped together under one application?
No. The intent is to fund centers that are coordinated and integrated, using a common center structure and shared methods rather than a set of unrelated projects.
Are clinical trials allowed under this P60 MCRC mechanism?
No. Clinical trials are not supported under this funding mechanism, and applicants must design clinical projects accordingly.
If clinical trials are not supported, what kind of research does NIAMS expect?
The announcement emphasizes clinical research within scope that relates to prevention, assessment, and/or patient outcomes for chronic NIAMS-relevant conditions, without proposing clinical trial activities that NIAMS will not fund through this P60 mechanism.
Does the program expect applicants to build new infrastructure from scratch?
No. The center is expected to leverage existing institutional infrastructure resources. Reviewers are likely to look for evidence of strong organizational capacity, established research environments, and feasible integration with institutional resources already in place.
What is the funding instrument and activity category for this opportunity?
The funding instrument is a grant, and the activity category is health.
What is the CFDA number associated with this opportunity?
The opportunity is listed under CFDA 93.846: Arthritis, Musculoskeletal and Skin Diseases Research.
What is the total estimated funding amount listed for this opportunity?
The total estimated funding listed is $6,000,000.
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
When was the opportunity posted?
The announcement was posted on March 25, 2011.
What is the closing date for applications?
The original and current closing date listed is June 24, 2011.
When was the opportunity archived?
The archive date listed is July 25, 2011.
Who is eligible to apply?
Eligibility is broad across many U.S.-based organization types, including public and private institutions of higher education; nonprofits (with or without 501(c)(3) status); for-profit organizations other than small businesses; small businesses; state and local governments (including counties, cities, townships, and special districts); independent school districts; public housing authorities/Indian housing authorities; federally recognized Native American tribal governments; tribal organizations (other than federally recognized tribal governments); and other entities as specified in the announcement.
Are minority-serving institutions included in the eligible applicants?
Yes. The announcement explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. The announcement explicitly includes faith-based or community-based organizations.
Are regional organizations eligible to apply?
Yes. Regional organizations are explicitly included in the eligibility description.
Are U.S. territories or possessions eligible?
Yes. The announcement explicitly includes U.S. territories or possessions.
Are federal agencies eligible to apply?
Yes. The eligibility list explicitly includes eligible federal agencies.
Can a foreign (non-U.S.) organization apply?
No. Non-U.S. entities (foreign organizations) are not eligible to apply.
Are foreign components of U.S. organizations allowed?
No. Foreign components of U.S. organizations are not allowed, meaning funded activities must be domestic in scope and implementation.
Where can applicants find the full announcement and official details?
The full announcement and details are available through the NIH grants page linked in the opportunity notice.
Where should technical access issues with the announcement be directed?
Technical access issues are directed to the NIH Office of Extramural Research (OER) webmaster contacts provided in the notice.
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