Opportunity Information: Apply for PAR 15 282

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Multidisciplinary Studies of HIV/AIDS and Aging (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.866 Aging Research.
  • This funding opportunity was created on Jun 18, 2015 and posted on Jun 18, 2015.
  • Applicants must submit their applications by Sep 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Special district governments Private institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses State governments Independent school districts Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education County governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Multidisciplinary Studies of HIV/AIDS and Aging (R21) funding opportunity (PAR-15-282) is an NIH discretionary grant program designed to support exploratory, early-stage research on how HIV and aging intersect. The central goal is to encourage studies that improve understanding of HIV infection and HIV-related health issues as people grow older, including the ways HIV treatments, comorbid conditions, and broader behavioral or social realities shape health outcomes in older adults. The announcement emphasizes multidisciplinary work, meaning proposals can draw from clinical medicine, public health, behavioral science, social science, epidemiology, and other relevant fields to better explain and address the complex needs of aging populations affected by HIV.

The scope of research is broad. Applicants are invited to investigate HIV infection itself, HIV-associated conditions, and HIV treatment in the context of aging. That can include studying how HIV interacts with age-related changes in the body, how long-term antiretroviral therapy influences health over time, and how HIV may contribute to or worsen conditions often seen in older age. In addition to biomedical questions, the FOA explicitly welcomes biobehavioral and social factors tied to HIV/AIDS among older adults, which can include issues such as adherence behaviors, mental health, substance use, stigma, isolation, access to care, housing stability, and other social determinants that affect prevention and treatment outcomes. The overall emphasis is on understanding real-world complexity rather than treating aging and HIV as separate issues.

In terms of research approaches, NIH signals interest in several major study types. Clinical translational research is encouraged, which typically includes work that bridges basic or clinical insights into practical applications for patient care. Observational studies are also within scope, such as cohort studies, analyses of clinical populations, surveillance-based research, and other designs that characterize risks, patterns, and outcomes in older adults with HIV. The FOA also calls for intervention studies, meaning applicants can propose and test strategies to improve health, healthcare delivery, adherence, prevention, or quality of life for older people living with HIV. Importantly, the opportunity is open to projects conducted in both domestic (U.S.-based) and international settings, reflecting NIH interest in HIV and aging as a global issue and allowing applicants to tailor studies to different healthcare systems and populations.

This is an R21 mechanism, which generally aligns with pilot or exploratory projects that can generate preliminary data, develop new methods, or test novel concepts that may later be expanded into larger studies. The listed award ceiling is $200,000, supporting smaller, focused projects rather than large-scale trials or long multi-site efforts. There is no cost sharing or matching requirement, so applicants are not required to contribute non-federal funds to the project budget.

Eligibility is intentionally broad and includes many types of organizations that can contribute to HIV and aging research. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (other than small businesses), and small businesses. Government entities at multiple levels may apply, including state governments, county governments, city or township governments, special district governments, and independent school districts, as well as public housing authorities/Indian housing authorities. Tribal entities are included, both federally recognized Native American tribal governments and other tribal organizations, along with tribally controlled colleges and universities. The FOA also allows participation from U.S. territories or possessions and explicitly includes non-U.S. entities (foreign organizations) and regional organizations, opening the door for international research teams and cross-border collaborations. It also highlights eligibility for a variety of minority-serving institutions (for example HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and AANAPISIS institutions), as well as faith-based and community-based organizations and eligible federal agencies.

Key administrative details from the source information include that the opportunity was posted and created on June 18, 2015, with an original and current closing date of September 7, 2018, and it was archived on October 8, 2018. The sponsoring agency is the National Institutes of Health, and the FOA is associated with a wide range of CFDA program areas across NIH that reflect the multidisciplinary nature of the topic, including mental health, alcohol and substance use, cancer, cardiovascular and lung disease, neurology, infectious diseases, and aging research, among others. For applicants or institutions needing help accessing the official announcement or resolving technical issues, NIH directs inquiries to the NIH Office of Extramural Research (OER) webmaster contact listed in the notice.

Frequently Asked Questions (FAQs): Multidisciplinary Studies of HIV/AIDS and Aging (R21) (PAR-15-282)

1) What is PAR-15-282?

PAR-15-282 is an NIH discretionary funding opportunity titled "Multidisciplinary Studies of HIV/AIDS and Aging (R21)." It supports exploratory, early-stage research focused on how HIV and aging intersect.

2) What is the main goal of this funding opportunity?

The central goal is to encourage research that improves understanding of HIV infection and HIV-related health issues as people grow older, including how HIV treatments, comorbid conditions, and behavioral or social realities shape outcomes for older adults.

3) What does "multidisciplinary" mean in this FOA?

"Multidisciplinary" means projects can draw on multiple fields to address complex HIV-and-aging questions. The announcement explicitly points to areas such as clinical medicine, public health, behavioral science, social science, and epidemiology, among other relevant disciplines.

4) What kinds of research topics are within scope?

The scope is broad and includes research on HIV infection, HIV-associated conditions, and HIV treatment in the context of aging. Examples described include how HIV interacts with age-related biological changes, how long-term antiretroviral therapy influences health over time, and how HIV may contribute to or worsen conditions often seen in older age.

5) Are behavioral and social topics allowed, or is this only biomedical?

Behavioral, biobehavioral, and social factors are explicitly welcomed. The FOA notes topics such as adherence behaviors, mental health, substance use, stigma, isolation, access to care, housing stability, and other social determinants that affect prevention and treatment outcomes in older adults.

6) What is the overall emphasis of the program?

The emphasis is on understanding real-world complexity rather than treating HIV and aging as separate issues, including how treatments, comorbidities, and social context combine to shape health outcomes.

7) What research approaches does NIH encourage under this opportunity?

NIH signals interest in several approaches, including:

  • Clinical translational research that bridges basic or clinical insights into practical applications for patient care
  • Observational studies such as cohort studies, analyses of clinical populations, and surveillance-based research
  • Intervention studies that propose and test strategies to improve health, healthcare delivery, adherence, prevention, or quality of life for older people living with HIV

8) Can projects be conducted outside the United States?

Yes. The opportunity is open to projects conducted in both domestic (U.S.-based) and international settings, reflecting NIH interest in HIV and aging as a global issue.

9) What does the R21 mechanism imply for project type and maturity?

An R21 generally aligns with pilot or exploratory projects intended to generate preliminary data, develop new methods, or test novel concepts that could later be expanded into larger studies.

10) What is the maximum award amount mentioned?

The listed award ceiling is $200,000, indicating support for smaller, focused projects rather than large-scale trials or long multi-site efforts.

11) Is cost sharing or matching required?

No. There is no cost sharing or matching requirement, so applicants are not required to contribute non-federal funds to the project budget.

12) Who is eligible to apply?

Eligibility is broad and includes many organization types, including:

  • Public and private institutions of higher education
  • Nonprofit organizations (with and without 501(c)(3) status, other than institutions of higher education)
  • For-profit organizations (other than small businesses)
  • Small businesses
  • State, county, city or township governments
  • Special district governments and independent school districts
  • Public housing authorities/Indian housing authorities
  • Federally recognized Native American tribal governments and other tribal organizations
  • Tribally controlled colleges and universities
  • U.S. territories or possessions
  • Non-U.S. entities (foreign organizations) and regional organizations
  • Faith-based and community-based organizations
  • Eligible federal agencies

13) Are minority-serving institutions specifically included?

Yes. The FOA highlights eligibility for a variety of minority-serving institutions, including examples such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and AANAPISIS institutions.

14) Which agency sponsors this opportunity?

The sponsoring agency is the National Institutes of Health (NIH).

15) When was the opportunity posted, and what are the closing and archive dates?

The opportunity was posted and created on June 18, 2015. The original and current closing date listed is September 7, 2018. It was archived on October 8, 2018.

16) Is this opportunity connected to specific NIH program areas?

Yes. The FOA is associated with a wide range of CFDA program areas across NIH, reflecting its multidisciplinary focus. Areas mentioned include mental health, alcohol and substance use, cancer, cardiovascular and lung disease, neurology, infectious diseases, and aging research, among others.

17) Where should applicants go if they have trouble accessing the official announcement or encounter technical issues?

NIH directs inquiries to the NIH Office of Extramural Research (OER) webmaster contact listed in the notice for help with accessing the official announcement or resolving technical issues.

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