Opportunity Information: Apply for RFA ES 15 013
Apply for RFA ES 15 013
- The National Institutes of Health in the environment health sector is offering a public funding opportunity titled "Nanomaterials Health Implications Research (NHIR) Comprehensive evaluation of interactions between engineered nanomaterials and biological system (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health.
- This funding opportunity was created on Jul 9, 2015 and posted on Jul 9, 2015.
- Applicants must submit their applications by Nov 30, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- Eligible applicants include: County governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education State governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Nanomaterials Health Implications Research (NHIR) grant opportunity (Funding Opportunity Number RFA-ES-15-013) is a National Institutes of Health (NIH) Funding Opportunity Announcement designed to fund cooperative agreement research projects (U01) focused on how engineered nanomaterials (ENMs) interact with biological systems. The central goal is to produce rich, comparable, and biologically meaningful "response profiles" that describe what ENMs do in living systems at the molecular, biochemical, cellular, and tissue/pathophysiological levels. Rather than supporting isolated, one-off studies on different materials, this FOA is structured around a coordinated consortium approach so that multiple funded teams investigate a shared set of ENMs and generate results that can be aligned, integrated, and interpreted across studies.
A key feature of the opportunity is that the U01 research projects are meant to plug into a broader NHIR consortium infrastructure. A companion FOA (RFA-ES-15-012) solicits applications for an Engineered Nanomaterials Resource and Coordination Core (ERCC). The ERCC is intended to serve as the organizing backbone for the consortium by providing the select ENMs and coordinating efforts so that the overall program can build comprehensive biological response profiles for nanomaterials that reflect the real-world "landscape" of nanotechnology applications. In practice, that means U01 awardees are expected to work with common materials and contribute data that are interoperable and useful to the consortium as a whole, rather than producing siloed datasets.
Scientifically, the FOA sits within the long-range goals of the NIEHS Nano Environmental Health and Safety (Nano EHS) program. The emphasis is on understanding how ENM physicochemical properties shape biological interactions and outcomes. In other words, the program is not only asking whether a given nanomaterial has an effect, but also pushing toward mechanistic and property-driven explanations that connect specific material characteristics to specific biological responses. This kind of characterization is aimed at building a deeper evidence base for predicting and evaluating potential health implications as nanomaterials move from development into broader use.
Because this is a cooperative agreement (U01) rather than a standard research grant, the program is explicitly collaborative and coordinated. Investigators funded under this FOA are expected to participate in annual consortium meetings coordinated by the ERCC and to carry out studies on the common ENM set. Cooperative agreements typically involve substantial NIH programmatic involvement, and the design here reinforces that the funded projects are intended to function as parts of a unified research effort rather than independent, loosely connected awards.
From an administrative and funding standpoint, the opportunity is categorized as a discretionary environmental health program under CFDA 93.113 (Environmental Health). The FOA was posted July 9, 2015, with an original and current closing date of November 30, 2015, and an archive date of December 31, 2015. The estimated total funding amount listed is $3,000,000, and the award ceiling is $300,000. The FOA states there is no cost-sharing or matching requirement, which means applicants are not required to provide non-federal matching funds as a condition of award.
Eligibility is broad across government, nonprofit, academic, and small business sectors. Eligible applicants include county governments; state governments; public and state-controlled institutions of higher education; private institutions of higher education; small businesses; and nonprofits both with and without 501(c)(3) status (so long as they are not institutions of higher education when specified). The announcement also highlights additional eligible applicant categories including various minority-serving institutions (such as HBCUs, Hispanic-serving institutions, AANAPISISs, TCCUs, and Alaska Native and Native Hawaiian Serving Institutions) as well as eligible federal government agencies. Foreign institutions and non-U.S. components of U.S. organizations are not eligible to apply, but "foreign components" as defined by NIH policy are allowed, which typically means certain project elements may occur outside the U.S. under NIH rules even when the applicant organization itself is domestic.
For applicants looking for the full official details, the FOA is linked through the NIH grants page at http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-15-013.html. Technical access issues are directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, which is the listed contact for problems accessing or linking to the announcement.
Nanomaterials Health Implications Research (NHIR) Grant (RFA-ES-15-013) - FAQs
1) What is the Nanomaterials Health Implications Research (NHIR) funding opportunity?
NHIR (Funding Opportunity Number RFA-ES-15-013) is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) that supports cooperative agreement research projects using the U01 mechanism. The focus is on understanding how engineered nanomaterials (ENMs) interact with biological systems and on generating biologically meaningful, comparable "response profiles" across studies.
2) What is the main goal of this FOA?
The central goal is to produce rich, comparable, and biologically meaningful response profiles describing what ENMs do in living systems at multiple biological levels, including molecular, biochemical, cellular, and tissue/pathophysiological levels.
3) What are "response profiles" in the context of this FOA?
In this FOA, response profiles refer to organized descriptions of biological responses to ENMs across different layers of biology (molecular through tissue/pathophysiological outcomes). A key intent is that these profiles be comparable and meaningful across multiple funded projects, not isolated to a single lab's methods or material choices.
4) How is this opportunity different from typical one-off nanomaterials studies?
Rather than funding isolated studies on different materials, the FOA is built around a coordinated consortium approach. Multiple funded teams are expected to investigate a shared set of ENMs so results can be aligned, integrated, and interpreted across studies.
5) What funding mechanism is used, and what does it imply?
This FOA uses the U01 cooperative agreement mechanism. That implies a collaborative, coordinated program structure with substantial NIH programmatic involvement, and expectations that funded projects operate as components of a unified research effort rather than as fully independent awards.
6) What is the NHIR consortium, and how do U01 awardees fit into it?
The U01 projects are designed to plug into a broader NHIR consortium infrastructure. Awardees are expected to work with common ENMs and contribute interoperable data that supports consortium-wide integration and interpretation.
7) What is the Engineered Nanomaterials Resource and Coordination Core (ERCC)?
The ERCC is a coordinating backbone for the consortium and is solicited under a companion FOA (RFA-ES-15-012). It is intended to provide the selected ENMs and coordinate efforts so the overall program can build comprehensive biological response profiles reflecting real-world nanotechnology applications.
8) Is there a companion funding opportunity associated with this FOA?
Yes. A companion FOA (RFA-ES-15-012) solicits applications for the Engineered Nanomaterials Resource and Coordination Core (ERCC), which is meant to organize and support consortium coordination and materials sharing.
9) Are applicants expected to study a common set of engineered nanomaterials (ENMs)?
Yes. A key expectation is that U01 awardees carry out studies on the common ENM set and contribute data that can be aligned and integrated across the consortium rather than producing siloed datasets.
10) What scientific theme does this FOA emphasize?
The FOA emphasizes understanding how ENM physicochemical properties shape biological interactions and outcomes. It is aimed at generating mechanistic and property-driven explanations that connect specific material characteristics to specific biological responses.
11) What larger program goals does this FOA align with?
This FOA sits within the long-range goals of the NIEHS Nano Environmental Health and Safety (Nano EHS) program, with an emphasis on building an evidence base for predicting and evaluating potential health implications as nanomaterials move into broader use.
12) What kinds of biological levels are included in the response profiling described by the FOA?
The FOA explicitly references profiling at the molecular, biochemical, cellular, and tissue/pathophysiological levels.
13) What consortium activities are U01 investigators expected to participate in?
Investigators funded under this FOA are expected to participate in annual consortium meetings coordinated by the ERCC, in addition to conducting studies on the common ENM set.
14) What is the CFDA number and program category for this opportunity?
The opportunity is categorized as a discretionary environmental health program under CFDA 93.113 (Environmental Health).
15) What are the important dates listed for this FOA?
The FOA was posted on July 9, 2015. The original and current closing date is November 30, 2015. The archive date is December 31, 2015.
16) What is the estimated total funding amount for this FOA?
The estimated total funding amount listed is $3,000,000.
17) What is the award ceiling for this opportunity?
The award ceiling listed for this FOA is $300,000.
18) Is cost-sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of award.
19) Who is eligible to apply?
Eligibility is broad and includes county governments; state governments; public and state-controlled institutions of higher education; private institutions of higher education; small businesses; and nonprofits with or without 501(c)(3) status (as described in the FOA), including eligible federal government agencies.
20) Are minority-serving institutions included in the eligible applicant categories?
Yes. The FOA highlights additional eligible categories including minority-serving institutions such as HBCUs, Hispanic-serving institutions, AANAPISISs, TCCUs, and Alaska Native and Native Hawaiian Serving Institutions.
21) Are foreign institutions eligible to apply?
No. Foreign institutions and non-U.S. components of U.S. organizations are not eligible to apply.
22) Are any international activities allowed under this FOA?
Yes. While foreign institutions cannot apply, "foreign components" (as defined by NIH policy) are allowed. This typically means certain project elements may occur outside the U.S. under NIH rules, provided the applicant organization itself is domestic.
23) Where can applicants find the official FOA text?
The FOA is available through the NIH grants page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-15-013.html
24) Who should be contacted for technical issues accessing or linking to the FOA?
Technical access issues are directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
25) What is the overarching purpose of coordinating projects through a consortium?
The coordinated consortium design is intended to ensure multiple teams generate results using shared ENMs so findings can be aligned and integrated, creating comprehensive biological response profiles that reflect the real-world landscape of nanotechnology applications.
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Previous opportunity: Nanomaterials Health Implications Research (NHIR) Engineered Nanomaterials Resource and Coordination Core (U24)
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