Nanoscience and Nanotechnology in Biology and Medicine (R01) | Apply Online

Opportunity Summary:

The Nanoscience and Nanotechnology in Biology and Medicine (R01) opportunity (Funding Opportunity Number PA-11-148) is a National Institutes of Health (NIH) discretionary grant announcement designed to fund investigator-initiated research projects that use nanoscience and nanotechnology to solve important problems in biology and medicine. The central aim is to accelerate cutting-edge nanoscale research that can open up new ways to understand how biology works at very small length scales and, in turn, translate those insights into practical biomedical advances. In plain terms, NIH is looking for strong R01 proposals where nanoscale concepts, materials, devices, or systems are essential to the scientific approach and where the work can plausibly move the needle on diagnosing, treating, or managing diseases and traumatic injuries, or on building foundational tools that make future biomedical discoveries possible.

A major emphasis of the announcement is the idea that biology itself is deeply nanoscale, and that meaningful breakthroughs can come from engineering and studying bioactive nanoscale structures, processes, and systems. Applications can be either more basic or more translational, as long as the nanoscience/nanotechnology component is substantive and drives the novelty of the work. On the basic science side, NIH explicitly encourages projects that create new or improved nanotechnology-enabled tools, methods, concepts, and devices that help researchers measure, visualize, manipulate, or model biological phenomena at the nanoscale. On the translational side, the FOA highlights development and investigation of nanoscale approaches that could lead to new diagnostics, therapeutics, delivery systems, monitoring technologies, or other medical innovations relevant to a wide range of health conditions, including diseases and traumatic injuries. The overall message is that proposals should push beyond incremental improvements and instead present a compelling nanoscale strategy that could enable new lines of investigation or produce clear biomedical value.

This is an R01 funding mechanism, meaning it supports full research projects rather than small pilot studies, and it follows the standard NIH grant structure and expectations for rigor, significance, innovation, approach, and investigator/environment fit. The announcement is broad in biomedical scope, which is reflected in the wide set of CFDA program areas associated with it. Those areas include, among others, environmental health (93.113), oral diseases (93.121), human genome research (93.172), communication disorders and deafness (93.173), alcohol research (93.273), drug abuse and addiction (93.279), technology innovations to improve human health (93.286), nursing research (93.361), cardiovascular research (93.837), arthritis and musculoskeletal/skin diseases (93.846), neurosciences and neurological disorders (93.853), allergy/immunology/transplantation (93.855), infectious diseases (93.856), general biomedical research and training (93.859), child health and human development (93.865), aging (93.866), and vision research (93.867). Practically, this breadth signals that nanotechnology applications are welcome across many organ systems, disease areas, and methodological domains, provided the project is compelling and fits NIH priorities.

Eligibility is broad and includes many kinds of U.S.-based organizations and government entities. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education, nonprofits (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status), for-profit organizations other than small businesses, and small businesses. Government applicants are also included, such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also calls out additional eligible applicant types such as historically black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), federally recognized tribal governments and other tribal organizations, faith-based or community-based organizations, and eligible federal agencies. U.S. territories or possessions and regional organizations are also included as eligible applicants. At the same time, the announcement is clear that non-U.S. entities (foreign organizations) are not eligible to apply, and foreign (non-U.S.) components of U.S. organizations are not allowed under this FOA.

There is no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of the award. The FOA was posted March 14, 2011, with an original closing date of May 7, 2014, and it is archived as of June 7, 2014. While the archived status means it is no longer accepting applications under that specific announcement, the content still provides a useful snapshot of NIH interests at the intersection of nanotechnology and biomedicine and is often representative of recurring NIH themes in later or successor solicitations.

For reference and full details, the FOA was hosted through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-11-148.html. The listed contact for access or linking issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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