Opportunity Information: Apply for PAR 16 047
Apply for PAR 16 047
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866,.
- This funding opportunity was created on Dec 04, 2015 and posted on Dec 04, 2015.
- Applicants must submit their applications by Sep 25, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The National Institute on Aging (NIA), part of the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services, offered a discretionary funding opportunity titled "National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (U24)" under Funding Opportunity Number PAR-16-047. The mechanism is a Cooperative Agreement (U24), which typically means the awardee is expected to work closely with NIH/NIA staff in an ongoing, collaborative way rather than operating completely independently. The overall purpose of the opportunity is to build and operate data infrastructure that can store and support analysis of both primary and secondary datasets related to the genetics and genomics of Alzheimer's disease, with an emphasis on making those data usable for the research community and on enabling more efficient discovery in Alzheimer's genetics.
At its core, the grant is focused on creating or maintaining a centralized "data storage site" that can handle the practical realities of modern genetics and genomics research. That includes managing large-scale genomic datasets (often produced by genome-wide association studies, whole-exome sequencing, whole-genome sequencing, and related approaches) and ensuring those data can be securely stored, properly curated, and made accessible in ways that support downstream analyses. The intention is not only to house data, but to support the broader research ecosystem by enabling investigators to retrieve datasets, combine them with other resources, and run analyses that help identify genetic risk factors, biological pathways, and potential therapeutic targets relevant to Alzheimer's disease.
The opportunity falls under the Health activity category and is associated with CFDA numbers 93.866 (and also lists 93.866 in the source), signaling alignment with NIH programs that support aging and age-related disease research. NIA’s emphasis on infrastructure reflects a recognition that progress in complex diseases like Alzheimer's depends heavily on well-managed, high-quality data resources, particularly for genetics where reproducibility, harmonization, and access controls are critical. By supporting a dedicated site for storage and analysis, NIA is effectively investing in shared capacity that can accelerate multiple projects and reduce duplicative effort across the field.
In terms of who could apply, eligibility was broad and included many types of U.S. organizations. Eligible applicants included state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (including both 501(c)(3) nonprofits and non-501(c)(3) nonprofits, excluding higher education institutions in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and additional entities as described in the solicitation’s eligibility clarification text. This broad eligibility suggests the program was designed to attract strong technical and operational teams wherever they exist, whether in academia, government, nonprofit data organizations, or qualified private-sector groups capable of running high-reliability biomedical data platforms.
The funding details indicate an award ceiling of $1,000,000 and an expectation of a single award. That combination points to a competitive, centralized effort intended to result in one primary awardee responsible for delivering a cohesive national resource, rather than distributing funds across multiple sites. The timeline in the source shows the opportunity was created and posted on December 4, 2015, with an original and current closing date of September 25, 2018, indicating a multi-year window during which applications could be submitted or the announcement could have remained active through re-issuance or standing receipt dates typical of some NIH program announcements.
Overall, this opportunity can be understood as NIA’s attempt to strengthen the backbone infrastructure needed for Alzheimer's genetics research: a robust platform for storing very large genomic datasets, curating and organizing them for consistent use, and enabling analysis workflows that help researchers translate genetic and genomic findings into clearer understanding of Alzheimer's disease. The cooperative agreement structure underscores that NIA intended to remain actively involved, likely to ensure the site aligns with evolving NIH data-sharing policies, privacy and security requirements, and the scientific priorities of the Alzheimer's research community.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The funding opportunity is titled "National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (U24)."
Which agency is offering this grant?
This opportunity was offered by the National Institute on Aging (NIA), which is part of the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services.
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PAR-16-047.
What type of funding mechanism is used for this opportunity?
The mechanism is a Cooperative Agreement (U24).
What does a Cooperative Agreement (U24) mean in practice?
A U24 Cooperative Agreement typically means the awardee is expected to work closely with NIH/NIA staff in an ongoing, collaborative way, rather than operating fully independently. NIA involvement is intended to help ensure the resource aligns with scientific priorities and relevant policies.
What is the overall purpose of this grant?
The purpose is to build and operate data infrastructure that can store and support analysis of both primary and secondary datasets related to the genetics and genomics of Alzheimer's disease, with an emphasis on making the data usable for the research community and enabling more efficient discovery in Alzheimer's genetics.
What kind of resource is being supported?
The opportunity focuses on creating or maintaining a centralized "data storage site" for Alzheimer's disease genetics and genomics data.
What types of data are intended to be stored and supported?
The site is intended to handle large-scale genomic datasets, including data generated by genome-wide association studies (GWAS), whole-exome sequencing, whole-genome sequencing, and related approaches. The opportunity also mentions support for both primary and secondary datasets connected to Alzheimer's genetics and genomics.
Is the goal only to store data, or also to enable research use?
The intent is not only to house data, but also to support the broader research ecosystem by enabling investigators to retrieve datasets, combine them with other resources, and run analyses to identify genetic risk factors, biological pathways, and potential therapeutic targets relevant to Alzheimer's disease.
Why is NIA investing in a data infrastructure site for Alzheimer's genetics?
NIA emphasizes that progress in complex diseases like Alzheimer's depends heavily on well-managed, high-quality data resources. For genetics and genomics, reproducibility, harmonization, and access controls are especially critical, and a shared infrastructure can accelerate discovery while reducing duplicative effort across the field.
What activity category is associated with this opportunity?
The opportunity falls under the Health activity category.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA 93.866 (and the source also lists 93.866).
Who is eligible to apply?
Eligibility was broad and included many types of U.S. organizations. Eligible applicants included:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other Native American tribal organizations
- Public housing authorities/Indian housing authorities
- Nonprofit organizations (501(c)(3) and non-501(c)(3), excluding higher education institutions in those nonprofit categories)
- For-profit organizations other than small businesses
- Small businesses
- Additional entities as described in the solicitation's eligibility clarification text
Does the broad eligibility mean the work could be done outside academia?
Yes. The eligible applicant list includes government, academic, nonprofit, and qualified private-sector organizations. This suggests the program was intended to attract strong technical and operational teams wherever they exist, as long as they can run a high-reliability biomedical data platform.
What is the maximum award amount (award ceiling)?
The award ceiling is $1,000,000.
How many awards were expected?
The opportunity indicates an expectation of a single award.
What does it imply that only one award was expected?
An expectation of a single award suggests a centralized effort, where one primary awardee would be responsible for delivering a cohesive national resource rather than splitting responsibilities across multiple sites.
When was the opportunity posted?
The opportunity was created and posted on December 4, 2015.
What was the closing date for applications?
The original and current closing date shown in the source is September 25, 2018.
Why does the opportunity show a multi-year window between posting and closing?
The timeline indicates a multi-year window during which applications could be submitted, or that the announcement could have remained active through re-issuance or standing receipt dates that are typical of some NIH program announcements.
What are the expected core functions of the data storage site described here?
Based on the description provided, the site is expected to address practical requirements of modern genetics and genomics research, including secure storage of very large datasets, curation and organization of data for consistent use, and support for access and analysis workflows that help the research community use the data effectively.
How does NIA's involvement affect the project direction over time?
The cooperative agreement structure indicates NIA intended to remain actively involved to help ensure the site aligns with evolving NIH data-sharing policies, privacy and security requirements, and the scientific priorities of the Alzheimer's research community.
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