Opportunity Information: Apply for RFA CA 12 014
Apply for RFA CA 12 014
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "NCI National Clinical Trials Network Network Radiotherapy and Imaging Core Services Centers (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research.
- This funding opportunity was created on Jul 23, 2012 and posted on Jul 23, 2012.
- Applicants must submit their applications by Jan 15, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $7,500,000.00 to eligible and selected applicants.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity RFA-CA-12-014 is a National Institutes of Health (NIH), National Cancer Institute (NCI) cooperative agreement (U24) aimed at setting up Network Radiotherapy and Imaging Core Services Centers to support the NCI National Clinical Trials Network (NCTN). In plain terms, NCI is looking for experienced institutions or organizations that can function as centralized, high-quality technical and operational hubs for radiotherapy and imaging within a national cancer clinical trials system. These centers are meant to provide the specialized infrastructure and expertise needed to run modern, multi-site cancer trials where consistent imaging and radiation therapy processes are critical for patient safety, data integrity, and interpretable trial results.
This FOA sits within the broader NCTN structure, which is designed to develop and conduct state-of-the-art cancer treatment trials and advanced imaging clinical trials. The emphasis is on large, definitive, multi-institutional studies that evaluate new cancer therapies and related clinical strategies for both adult and pediatric patients. NCI is essentially investing in the backbone capabilities that make those large trials feasible across many hospitals and research sites, especially when the trial depends on sophisticated imaging endpoints or precise, protocol-driven radiotherapy planning and delivery. By funding dedicated core service centers, the NCTN can standardize methods, reduce variability between participating sites, and improve the reliability of outcomes when treatments and imaging assessments are compared across a national network.
The announcement also clarifies that the NCTN is made up of six coordinated components, each supported through its own separate funding opportunity. Those components include Network Group Operations Centers, Network Group Statistics and Data Management Centers, Network Group Integrated Translational Science Centers, Lead Academic Participating Site Centers, the Network Radiotherapy and Imaging Core Services Centers covered by this FOA, and a Canadian Collaborating Clinical Trials Network. This matters because applicants are not applying to run the whole NCTN; they are applying to operate one of the specialized radiotherapy and imaging core service centers that plug into, and collaborate closely with, the other network components. The cooperative agreement mechanism (U24) signals that NCI expects substantial involvement in coordinating activities, setting expectations, and aligning the funded centers with network-wide standards and priorities, rather than operating as a fully independent, investigator-directed project.
From an eligibility standpoint, the FOA is open to a broad set of U.S.-based organizational applicants. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (with the stated caveat that some categories exclude institutions of higher education), for-profit organizations other than small businesses, and certain other organizational types referenced in the FOA text. The opportunity explicitly includes several institution types under “other eligible applicants,” such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and regional organizations. At the same time, it draws a firm boundary on foreign involvement: non-U.S. entities (foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, “foreign components” as defined under NIH policy are allowed, meaning a U.S. applicant may be able to include certain defined foreign collaborations or elements if they meet NIH requirements, even though the primary applicant organization must be domestic.
Financially, the FOA lists an estimated total funding level of $7,500,000, with no cost sharing or matching requirement. The announcement was posted on July 23, 2012, with an original and current closing date of January 15, 2013, and an archive date of February 15, 2013, indicating the solicitation is historical rather than currently open. The program is tied to CFDA numbers 93.394 (Cancer Detection and Diagnosis Research) and 93.395 (Cancer Treatment Research), which reflects the dual role these centers play: imaging is central to diagnosis and response assessment, while radiotherapy is a core treatment modality that must be rigorously standardized in clinical trials.
Operationally, while the short synopsis does not enumerate every required task, the intent is clear: these centers are expected to provide network-level radiotherapy and imaging core services that enable consistent trial implementation across multiple institutions. In practice, that typically includes capabilities like protocol support, quality assurance processes, standardization of imaging acquisition and interpretation approaches, management of radiotherapy planning and delivery benchmarks, credentialing or readiness assessment of participating sites, and centralized expertise to resolve technical questions that arise during trial activation and conduct. The overall rationale is that advanced imaging and radiotherapy introduce complex sources of variation across sites, so having dedicated core centers helps ensure that trial endpoints are measured consistently and that treatment is delivered in a manner that matches the protocol assumptions used to interpret outcomes.
Finally, the FOA provides a link to the full announcement on the NIH grants website and includes contact directions for applicants who have technical issues accessing the posting (via the NIH Office of Extramural Research webmaster). For anyone evaluating this opportunity historically or trying to understand how NCI structured the NCTN buildout, the key takeaway is that NCI used a set of coordinated FOAs to fund complementary network functions, and this particular FOA focused on building the shared radiotherapy and imaging infrastructure required to run high-quality, nationwide cancer clinical trials at scale.
Frequently Asked Questions (FAQs) - RFA-CA-12-014 (NCI/NIH U24)
What is the funding opportunity RFA-CA-12-014 about?
RFA-CA-12-014 is a National Institutes of Health (NIH), National Cancer Institute (NCI) cooperative agreement (U24) intended to establish Network Radiotherapy and Imaging Core Services Centers. These centers are meant to act as centralized technical and operational hubs that support radiotherapy and imaging needs across the NCI National Clinical Trials Network (NCTN).
In practical terms, what is NCI trying to fund through this FOA?
NCI is looking to fund experienced institutions or organizations that can provide consistent, high-quality radiotherapy and imaging core services for a national cancer clinical trials system. The goal is to make it easier to run modern, multi-site trials where standardized imaging and precise, protocol-driven radiotherapy are essential for patient safety, reliable data, and interpretable results.
What type of award mechanism is used, and what does it imply?
This FOA uses a cooperative agreement mechanism (U24). That structure indicates NCI expects substantial involvement in coordinating activities, setting expectations, and aligning the funded centers with network-wide standards and priorities (as opposed to a fully independent, investigator-directed project).
What is the NCI National Clinical Trials Network (NCTN) and why does it matter here?
The NCTN is designed to develop and conduct state-of-the-art cancer treatment trials and advanced imaging clinical trials, emphasizing large, definitive, multi-institutional studies for adult and pediatric patients. This FOA matters because it funds the shared radiotherapy and imaging infrastructure that helps those large trials run consistently across many sites.
Is this FOA intended to fund the entire NCTN?
No. The NCTN is made up of six coordinated components, each supported through its own separate funding opportunity. Applicants under RFA-CA-12-014 are applying specifically to operate one of the Network Radiotherapy and Imaging Core Services Centers, not to run the whole NCTN.
What are the six coordinated components of the NCTN mentioned in the announcement?
The announcement describes the NCTN as consisting of six coordinated components: Network Group Operations Centers, Network Group Statistics and Data Management Centers, Network Group Integrated Translational Science Centers, Lead Academic Participating Site Centers, Network Radiotherapy and Imaging Core Services Centers (this FOA), and a Canadian Collaborating Clinical Trials Network.
Who is eligible to apply?
Eligibility is open to a broad set of U.S.-based organizational applicants, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (with a noted caveat that some categories exclude institutions of higher education), for-profit organizations other than small businesses, and other organizational types referenced in the FOA.
Are specific institution types explicitly included under "other eligible applicants"?
Yes. The FOA explicitly includes certain institution types under "other eligible applicants," including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and regional organizations.
Are foreign organizations eligible to apply?
No. Non-U.S. entities (foreign institutions) are not eligible to apply under this FOA.
Can a U.S. organization apply if it has a non-U.S. component?
Non-domestic components of U.S. organizations are not eligible to apply. However, the FOA states that "foreign components" as defined under NIH policy are allowed, meaning a domestic U.S. applicant may be able to include certain foreign collaborations or elements if they meet NIH requirements, even though the primary applicant must be domestic.
How much total funding was estimated for this opportunity?
The FOA lists an estimated total funding level of $7,500,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
When was this funding opportunity posted, and what were the key dates?
The announcement was posted on July 23, 2012. The original and current closing date listed is January 15, 2013, and the archive date is February 15, 2013.
Is this funding opportunity currently open?
Based on the listed closing date (January 15, 2013) and archive date (February 15, 2013), the solicitation is historical rather than currently open.
What are the CFDA numbers associated with this program?
The FOA is tied to CFDA numbers 93.394 (Cancer Detection and Diagnosis Research) and 93.395 (Cancer Treatment Research).
Why are there two CFDA numbers (detection/diagnosis and treatment) linked to this FOA?
The FOA frames these centers as supporting both advanced imaging and radiotherapy within clinical trials. Imaging is central to diagnosis and response assessment, while radiotherapy is a major treatment modality that must be standardized and quality-controlled across trial sites.
What is the overall purpose of creating Network Radiotherapy and Imaging Core Services Centers?
The purpose is to provide network-level infrastructure and expertise so radiotherapy and imaging processes are consistent across many hospitals and research sites. This standardization helps reduce variability, improves patient safety, strengthens data integrity, and increases confidence that trial endpoints are comparable across the national network.
What kinds of activities are these centers expected to support?
While the synopsis does not list every required task, it describes the intent for network-level radiotherapy and imaging core services. Examples provided or implied include protocol support, quality assurance processes, standardization of imaging acquisition and interpretation approaches, management of radiotherapy planning and delivery benchmarks, credentialing or readiness assessment of participating sites, and centralized expertise to resolve technical questions during trial activation and conduct.
Why does NCI emphasize standardization and quality across multiple sites?
Because modern radiotherapy and advanced imaging can introduce complex sources of variation between institutions. Dedicated core service centers help ensure trial endpoints are measured consistently and that treatment delivery matches the protocol assumptions used to interpret outcomes.
How do these centers fit into the broader NCTN buildout?
NCI used a set of coordinated FOAs to fund complementary network functions across the NCTN. This specific FOA funds the shared radiotherapy and imaging infrastructure that "plugs into" and collaborates closely with the other NCTN components rather than operating in isolation.
Where can the full announcement be found, and what if someone has trouble accessing it?
The FOA indicates the full announcement is available on the NIH grants website. It also includes contact directions for technical issues accessing the posting via the NIH Office of Extramural Research webmaster.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA CA 12 014) also looked into and applied for these:
| Funding Opportunity |
|---|
| NCI National Clinical Trials Network Canadian Collaborating Clinical Trials Network (Limited Competition U10) Apply for RFA CA 12 504 Funding Number: RFA CA 12 504 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI National Clinical Trials Network Network Group Operations Centers (U10) Apply for RFA CA 12 010 Funding Number: RFA CA 12 010 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI National Clinical Trials Network Network Group Statistics and Data Management Centers (U10) Apply for RFA CA 12 011 Funding Number: RFA CA 12 011 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI National Clinical Trials Network Network Group Integrated Translational Science Centers (U10) Apply for RFA CA 12 012 Funding Number: RFA CA 12 012 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI National Clinical Trials Network Network Lead Academic Participating Sites (U10) Apply for RFA CA 12 013 Funding Number: RFA CA 12 013 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Behavioral Science Track Award for Rapid Transition (B/START) (R03) Apply for PAR 12 251 Funding Number: PAR 12 251 Agency: National Institutes of Health Category: Education Health Funding Amount: $75,000 |
| SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer Therapeutics, Imaging Technologies, Interventional Devices, Diagnostics, and Prognostics Toward Commercialization (R44) Apply for RFA CA 12 023 Funding Number: RFA CA 12 023 Agency: National Institutes of Health Category: Education Health Funding Amount: $1,000,000 |
| The Interplay of Substance Abuse and HIV 1 Infection on Glial Cell Function (R01) Apply for RFA DA 13 010 Funding Number: RFA DA 13 010 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| The Interplay of Substance Abuse and HIV 1 Infection on Glial Cell Function (R21) Apply for RFA DA 13 011 Funding Number: RFA DA 13 011 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Examination of Survivorship Care Planning Efficacy and Impact R21 Apply for PA 12 274 Funding Number: PA 12 274 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Examination of Survivorship Care Planning Efficacy and Impact R01 Apply for PA 12 275 Funding Number: PA 12 275 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| FY 2013 American Schools and Hospitals Abroad Program Apply for DRAFT APS ASHA 12 000001 Funding Number: DRAFT APS ASHA 12 000001 Agency: Agency for International Development Category: Education Health Funding Amount: $2,000,000 |
| HIV/AIDS, Drug Use, and Vulnerable Populations in the US (R21) Apply for PA 12 280 Funding Number: PA 12 280 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| HIV/AIDS, Drug Use, and Vulnerable Populations in the US (R01) Apply for PA 12 281 Funding Number: PA 12 281 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| AIDS Science Track Award for Research Transition (R03) Apply for PA 12 282 Funding Number: PA 12 282 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Revisions for Early Stage Development of Informatics Technology (R01) Apply for PAR 12 286 Funding Number: PAR 12 286 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Advanced Development of Informatics Technology (U24) Apply for PAR 12 287 Funding Number: PAR 12 287 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Early Stage Development of Informatics Technology (U01) Apply for PAR 12 288 Funding Number: PAR 12 288 Agency: National Institutes of Health Category: Education Health Funding Amount: $250,000 |
| Revisions for Early Stage Development of Informatics Technology (U01) Apply for PAR 12 289 Funding Number: PAR 12 289 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Revisions for Early Stage Development of Informatics Technology (P01) Apply for PAR 12 290 Funding Number: PAR 12 290 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
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