Opportunity Information: Apply for PA 13 283
Apply for PA 13 283
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NEI Audacious Goals Initiative in Vision Research High Priority Research Area Molecular Therapies for Eye Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.867 Vision Research.
- This funding opportunity was created on Jul 24, 2013 and posted on Jul 24, 2013.
- Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities State governments City or township governments County governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses Independent school districts Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NEI Audacious Goals Initiative in Vision Research High Priority Research Area: Molecular Therapies for Eye Disease (R01) (Funding Opportunity Number PA 13 283) is a National Institutes of Health (NIH) National Eye Institute (NEI) grant opportunity designed to push forward new, molecularly based treatments for eye disease and vision loss. It sits within NEI's broader "Audacious Goals" effort, which flags especially high-impact research directions that could meaningfully change what is possible in preventing blindness or restoring sight. This announcement specifically encourages applicants to bring forward fresh, innovative R01 projects that move molecular therapy concepts toward real therapeutic strategies for diseases affecting any part of the visual system, not just the retina.
The scientific focus is deliberately broad but organized around two main molecular-therapy pathways. First, it supports research aimed at the control, modification, and delivery of genetic information, which can include approaches typically associated with gene therapy and gene regulation (for example, methods to deliver genetic payloads, turn genes on or off, correct mutations, or otherwise alter gene expression in target ocular tissues). Second, it invites molecular approaches beyond genetics, emphasizing development of small-molecule therapies and optogenetic strategies. Small molecules can include drug-like compounds intended to modify disease pathways, protect cells, or improve function. Optogenetic approaches are framed as a way to restore visual function by conferring light sensitivity to cells that normally are not photoreceptors, or by otherwise re-engineering signaling pathways to recover useful vision. The overarching intent is treatment development, meaning the FOA is looking for work that has a clear therapeutic direction rather than purely descriptive biology.
In terms of project style, the announcement is flexible about how applicants get to the end goal. Proposals may be design-directed (engineering or design-led development of a therapy platform), developmental (maturing tools, delivery systems, or candidate interventions), discovery-driven (identifying new therapeutic targets or molecular strategies that can be translated), or hypothesis-driven (testing defined mechanistic ideas that underpin a therapeutic approach). NEI also signals that small, multidisciplinary teams are appropriate and even encouraged, particularly where success depends on integrating multiple areas of expertise such as molecular genetics, chemistry, bioengineering, ophthalmology, neuroscience, computational analysis, imaging, or translational model development. The expectation is that integrative, team-based work can accelerate progress on difficult problems like targeted delivery in the eye, durable expression or control of therapeutic effects, and safe restoration of function.
Administratively, this is a discretionary NIH grant using the R01 mechanism, listed under the Health funding activity category and CFDA number 93.867 (Vision Research). The opportunity does not require cost sharing or matching. It was posted and created on July 24, 2013, with an original and current closing date of September 7, 2016, and an archive date of October 8, 2016, indicating it is no longer open for new submissions under that specific announcement version.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants span public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (other than small businesses) and small businesses, as well as various government entities (state, county, city/township, special district governments), independent school districts, and public or Indian housing authorities. The FOA also explicitly includes a wide set of institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander-Serving Institutions (AANAPISIs), along with eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and tribal governments (including federally recognized and other tribal organizations). Importantly, foreign organizations and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations may participate, and foreign components (as defined by NIH policy) are allowed, which opens the door to international expertise when it strengthens the proposed science.
For reference and full details, the announcement points applicants to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/pa-files/PA-13-283.html (as originally formatted in the source data) and provides NIH Office of Extramural Research (OER) webmaster contacts for technical access or linking problems (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the NEI Audacious Goals Initiative in Vision Research: Molecular Therapies for Eye Disease (R01)?
This is a National Institutes of Health (NIH) National Eye Institute (NEI) funding opportunity that supports R01 research projects aimed at advancing molecularly based treatments for eye disease and vision loss. It is part of NEI's broader "Audacious Goals" effort, which highlights high-impact research directions intended to meaningfully change what is possible in preventing blindness or restoring sight.
What is the Funding Opportunity Number and title?
The opportunity is titled "The NEI Audacious Goals Initiative in Vision Research High Priority Research Area: Molecular Therapies for Eye Disease (R01)" and the Funding Opportunity Number is PA 13 283.
Which NIH institute is sponsoring this opportunity?
The sponsoring institute is the NIH National Eye Institute (NEI).
What grant mechanism does this opportunity use?
This opportunity uses the NIH R01 mechanism.
What is the main purpose or goal of this FOA?
The FOA is designed to push forward new molecular therapy concepts toward real therapeutic strategies for eye disease and vision loss. The emphasis is on treatment development with a clear therapeutic direction, rather than purely descriptive biology.
What parts of the visual system are within scope?
Projects may target diseases affecting any part of the visual system, not only the retina.
What are the main scientific pathways or areas of emphasis?
The FOA is broad but organized around two main molecular-therapy pathways: (1) control, modification, and delivery of genetic information (including gene therapy and gene regulation approaches), and (2) molecular approaches beyond genetics, with emphasis on small-molecule therapies and optogenetic strategies.
What types of gene-based approaches are included under "control, modification, and delivery of genetic information"?
Examples described include methods to deliver genetic payloads, turn genes on or off, correct mutations, or otherwise alter gene expression in target ocular tissues.
Are non-genetic molecular therapies supported?
Yes. The FOA explicitly invites molecular approaches beyond genetics, emphasizing development of small-molecule therapies and optogenetic strategies.
What are "small-molecule" therapies in the context of this FOA?
Small molecules are described as drug-like compounds intended to modify disease pathways, protect cells, or improve function.
What are optogenetic strategies in the context of this FOA?
Optogenetic approaches are framed as a way to restore visual function by conferring light sensitivity to cells that normally are not photoreceptors, or by otherwise re-engineering signaling pathways to recover useful vision.
Does the FOA prefer certain research styles (e.g., hypothesis-driven vs. discovery-driven)?
The announcement is flexible and notes that proposals may be design-directed, developmental, discovery-driven, or hypothesis-driven, as long as the work moves molecular therapy concepts toward therapeutic strategies.
Are multidisciplinary teams encouraged?
Yes. NEI signals that small, multidisciplinary teams are appropriate and encouraged, especially when success depends on integrating multiple areas of expertise.
What types of expertise does the FOA suggest may be relevant?
Examples mentioned include molecular genetics, chemistry, bioengineering, ophthalmology, neuroscience, computational analysis, imaging, and translational model development.
What kinds of challenges is the program trying to accelerate progress on?
The FOA highlights difficult problems such as targeted delivery in the eye, durable expression or control of therapeutic effects, and safe restoration of function.
What is the funding activity category and CFDA number?
The funding activity category is Health, and the CFDA number is 93.867 (Vision Research).
Is cost sharing or matching required?
No. The opportunity states that cost sharing or matching is not required.
Is this funding opportunity still open for applications?
No. It lists an original and current closing date of September 7, 2016, and an archive date of October 8, 2016, indicating it is no longer open for new submissions under that specific announcement version.
When was this opportunity posted and created?
It was posted and created on July 24, 2013.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. and non-U.S. organizations, including higher education institutions, nonprofits, for-profit organizations (other than small businesses) and small businesses, and various government entities.
Are U.S. colleges and universities eligible?
Yes. Eligible applicants include public and private institutions of higher education.
Are nonprofits eligible?
Yes. Eligibility includes nonprofits, including 501(c)(3) organizations and certain non-501(c)(3) nonprofits.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
Are government entities eligible to apply?
Yes. The FOA includes state, county, city/township, and special district governments, among other government-related entity types.
Are independent school districts or housing authorities eligible?
Yes. Independent school districts and public or Indian housing authorities are included in the eligibility list.
Does the FOA include specific categories of minority-serving institutions?
Yes. The FOA explicitly includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander-Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included among eligible applicants.
Are tribal governments and tribal organizations eligible?
Yes. The FOA includes tribal governments (including federally recognized and other tribal organizations).
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included in the eligibility description.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA states that foreign organizations and foreign institutions are eligible to apply.
Can non-U.S. components of U.S. organizations participate?
Yes. Non-U.S. components of U.S. organizations may participate.
Are foreign components allowed under NIH policy?
Yes. The FOA indicates that foreign components (as defined by NIH policy) are allowed.
Where can applicants find the full announcement text?
The FOA points to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/pa-files/PA-13-283.html.
Who should be contacted for technical access or linking problems?
The NIH Office of Extramural Research (OER) webmaster contact listed is FBOWebmaster@OD.NIH.GOV for technical access or linking problems.
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