Opportunity Information: Apply for PAR 14 099
Apply for PAR 14 099
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NEI Clinical Vision Research Clinical Center Grant (UG1)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.867 Vision Research.
- This funding opportunity was created on Feb 12, 2014 and posted on Feb 12, 2014.
- Applicants must submit their applications by May 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Private institutions of higher education Public housing authorities/Indian housing authorities County governments For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal governments (Federally recognized) Small businesses City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NEI Clinical Vision Research Clinical Center Grant (UG1) (Funding Opportunity Number PAR 14 099) is a National Institutes of Health National Eye Institute funding opportunity designed to support investigator-initiated clinical vision research that is complex, high-risk, or operationally demanding. The program is built to enable studies that often require rigorous clinical infrastructure, strong coordination, and close interaction with NIH program staff. Projects supported under this announcement can include multi-center clinical trials, studies involving human gene transfer, stem cell therapy research in humans, and other advanced clinical investigations in vision science where a standard research grant structure may not be sufficient to handle the scientific, regulatory, and logistical complexity.
This FOA uses the cooperative agreement mechanism (UG1), which means it is not a typical independent grant where the awardee operates with minimal federal involvement. Instead, a cooperative agreement generally reflects a partnership model in which NIH and the funded institution have substantial scientific and/or programmatic interaction during the project. In practical terms, applicants should expect structured oversight, milestone-driven expectations, and ongoing coordination with NEI and other study components when relevant. The intent is to make it possible to successfully conduct demanding clinical vision studies where coordination, compliance, safety monitoring, and standardized procedures are central to the research.
A key feature of this announcement is its emphasis on single-component applications. NEI notes that large clinical programs are often organized either as a single award containing multiple components (for example, a Chair unit, Coordinating Center, Clinical Center, and Resource Center) or as multiple linked awards issued to different institutions, each responsible for a distinct component. PAR 14 099 specifically encourages applications for a single component grant award, which commonly corresponds to a Clinical Center role within a broader networked effort. Institutions seeking to propose a multi-component structure within one overall application are directed instead to the companion opportunity, PAR 14 096, which is intended for the multi-component approach.
The opportunity falls under the Health funding activity category and is associated with CFDA number 93.867 (Vision Research). It does not require cost sharing or matching, which can reduce barriers for institutions that might otherwise struggle to commit institutional funds. The announcement was posted on February 12, 2014, with an original and current closing date listed as May 7, 2017, and an archive date of June 7, 2017. Those dates indicate the FOA is no longer active for new submissions, but it remains important as a reference point for understanding NEI’s preferred structures for clinical center participation and cooperative agreement expectations.
Eligibility is broad and includes many U.S.-based organization types as well as non-U.S. entities. Eligible applicants listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, and a wide range of government entities (state, county, city or township, special district governments), as well as public/Indian housing authorities. The FOA also explicitly includes many institution types that NIH often highlights for outreach and inclusion, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI).
Notably, foreign participation is allowed. Non-domestic (non-U.S.) entities and foreign institutions are eligible to apply, and non-domestic components of U.S. organizations may also participate. Foreign components, as defined in the NIH Grants Policy Statement, are permitted. This matters for clinical vision research because recruitment, rare disease cohorts, specialized clinical capabilities, and certain trial networks may be international in scope, and the FOA framework accommodates that reality.
For applicants and project planners, the central takeaway is that PAR 14 099 was meant to support the Clinical Center function within demanding clinical vision research programs under a cooperative agreement model. It is aimed at studies where patient-facing clinical research operations, adherence to protocol-driven procedures, and strong coordination with a broader trial structure are essential. For those needing the full official requirements, the source announcement was provided through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PAR-14-099.html, and NIH’s Office of Extramural Research webmaster contact was listed for access or linking issues (FBOWebmaster@OD.NIH.GOV).
FAQs: NEI Clinical Vision Research Clinical Center Grant (UG1) (PAR-14-099)
What is PAR-14-099?
PAR-14-099 is a National Institutes of Health (NIH), National Eye Institute (NEI) funding opportunity for investigator-initiated clinical vision research conducted under the cooperative agreement mechanism (UG1). It was intended to support clinical studies that are complex, high-risk, or operationally demanding.
Which NIH Institute sponsors this opportunity?
This opportunity is sponsored by the NIH National Eye Institute (NEI).
What is the funding mechanism used?
The FOA uses the UG1 cooperative agreement mechanism, which is designed for projects that require substantial scientific and/or programmatic interaction between NIH and the funded institution.
How is a cooperative agreement (UG1) different from a typical research grant?
Under a UG1 cooperative agreement, NIH involvement is more substantial than in a typical independent grant. Applicants should expect structured oversight, milestone-driven expectations, and ongoing coordination with NEI and other study components when relevant.
What types of projects were intended to be supported?
The FOA was designed to support demanding clinical vision studies, including examples such as multi-center clinical trials, studies involving human gene transfer, stem cell therapy research in humans, and other advanced clinical investigations where a standard research grant structure may be insufficient for the scientific, regulatory, and logistical complexity.
What makes a project a good fit for this FOA (based on the description provided)?
Projects were expected to require rigorous clinical infrastructure, strong coordination, and close interaction with NIH program staff, especially where coordination, compliance, safety monitoring, and standardized procedures are central to successful execution.
Is this FOA meant for multi-center studies?
Yes. Multi-center clinical trials are explicitly mentioned as an example of the kinds of studies that may be supported under this announcement.
Does this FOA support research involving human gene transfer or stem cell therapy in humans?
Yes. The description explicitly includes studies involving human gene transfer and stem cell therapy research in humans as examples of advanced clinical investigations that may be supported.
What is meant by the "Clinical Center" focus in this program?
The FOA emphasizes a single-component application that commonly corresponds to a Clinical Center role within a broader, networked clinical research effort. The Clinical Center function is framed as patient-facing clinical research operations with protocol-driven procedures and strong coordination needs.
Does PAR-14-099 allow a single application with multiple components?
The announcement specifically emphasizes single-component applications and notes that institutions seeking a multi-component structure within one overall application should use the companion opportunity PAR-14-096 instead.
What is the companion FOA for multi-component applications?
The companion opportunity referenced for multi-component, single-award structures is PAR-14-096.
What is the activity category associated with this FOA?
The opportunity falls under the Health funding activity category.
What CFDA number is associated with this opportunity?
The FOA is associated with CFDA number 93.867 (Vision Research).
Is cost sharing or matching required?
No. The FOA indicates that cost sharing or matching is not required.
Is this funding opportunity still active?
No. The original and current closing date is listed as May 7, 2017, with an archive date of June 7, 2017. Based on those dates, it is no longer active for new submissions.
When was the FOA posted?
The announcement was posted on February 12, 2014.
What were the close and archive dates listed for the FOA?
The closing date is listed as May 7, 2017, and the archive date is listed as June 7, 2017.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organization types and non-U.S. entities. Eligible applicants listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and certain nonprofits without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, and various government entities (state, county, city/township, special district governments), as well as public/Indian housing authorities.
Are minority-serving institutions included in eligibility?
Yes. The FOA explicitly includes institution types often highlighted for outreach and inclusion, including HBCUs, Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISI institutions.
Are foreign organizations eligible to apply?
Yes. Non-domestic (non-U.S.) entities and foreign institutions are eligible to apply.
Can foreign components of U.S. organizations participate?
Yes. Non-domestic components of U.S. organizations may participate, and foreign components (as defined in the NIH Grants Policy Statement) are permitted.
Why might international participation matter for this FOA?
The description notes that clinical vision research may be international in scope due to recruitment needs, rare disease cohorts, specialized clinical capabilities, and trial networks, and that the FOA framework accommodates foreign participation.
Where can applicants find the official NIH Grants Guide announcement?
The FOA is available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-099.html
Who is listed as a contact for access or linking issues?
The NIH Office of Extramural Research webmaster contact listed is FBOWebmaster@OD.NIH.GOV.
What is the main program intent of PAR-14-099 as described?
The central intent was to support the Clinical Center function within demanding clinical vision research programs using a cooperative agreement model, especially where clinical operations, protocol adherence, and coordination within a broader trial structure are essential.
What Funding Opportunity Number is associated with this program?
The Funding Opportunity Number provided is PAR 14 099 (PAR-14-099).
Browse more opportunities from the same category: Health
Next opportunity: NEI Clinical Vision Research Coordinating Center Grant (UG1)
Previous opportunity: NEI Clinical Vision Research Chairmans Grant (UG1)
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