Opportunity Information: Apply for PA 14 068
Apply for PA 14 068
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Neurobiology of Migraine (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.273 Alcohol Research Programs 93.313 NIH Office of Research on Womens Health 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Jan 13, 2014 and posted on Jan 13, 2014.
- Applicants must submit their applications by May 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Private institutions of higher education State governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Special district governments Small businesses City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public housing authorities/Indian housing authorities County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Neurobiology of Migraine (R01) opportunity (Funding Opportunity Number PA 14-068) was a discretionary NIH research grant announcement led by the National Institute of Neurological Disorders and Stroke (NINDS) in partnership with the NIH Pain Consortium. It invited R01 applications proposing innovative, hypothesis-driven research aimed at clarifying the biological mechanisms that cause migraine, explaining why some people are more susceptible than others, and identifying better ways to treat and prevent migraine. The overall intent was to push beyond descriptive clinical observations and generate mechanistic evidence that can translate into improved acute management and longer-term preventive strategies.
A central emphasis of the announcement was deepening the field's understanding of migraine pathophysiology and progression. Projects were expected to tackle how migraine arises and evolves by examining multiple layers of influence, including genetic factors, physiological mechanisms, biopsychosocial contributors, and environmental exposures. In practical terms, this could encompass studies of neural circuits involved in pain processing, sensory hypersensitivity, aura-related mechanisms, trigeminovascular biology, neuroimmune and inflammatory signaling, hormonal or sex-related influences, stress and comorbidity interactions, or how environmental triggers and life experiences shape risk, frequency, chronification, and disability. The FOA also highlighted the discovery and validation of new therapeutic targets, as well as the exploration of potential therapies relevant to both acute migraine treatment and prevention, signaling interest in work that could lead to new classes of interventions or better use of existing approaches.
The funding mechanism was the NIH R01, which is the standard, investigator-initiated research project grant used for mature, well-developed proposals with rigorous aims and methods. The activity category was Health, and the sponsor agency was the National Institutes of Health. The announcement did not require cost sharing or matching, which generally lowers barriers for applicants by not obligating them to provide non-federal funds as a condition of the award.
Eligibility for this FOA was broad and included many types of domestic and international organizations. Eligible applicants listed in the announcement included public and private institutions of higher education, nonprofit organizations (both those with and without 501(c)(3) status), for-profit organizations (including small businesses and other than small businesses), and a wide range of government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. It also explicitly welcomed applications from Tribal governments and Tribal organizations, including federally recognized Tribal governments as well as other Tribal entities, and it noted eligibility for a variety of mission-driven and community-rooted institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based and community-based organizations were included as eligible as well. Importantly, non-U.S. entities were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were allowed, reflecting NIH's willingness to support strong migraine research wherever the science and capability exist.
From an administrative standpoint, the FOA was posted on January 13, 2014, with an original and current closing date of May 7, 2017, and it was archived on June 7, 2017. The listing included multiple CFDA numbers tied to NIH research programs spanning neurosciences and neurological disorders and related areas, reflecting the cross-cutting relevance of migraine research to broader NIH priorities (including pain, neuroscience, and conditions that intersect with communication disorders, oral health, alcohol research, complementary and integrative health, and women's health). Applicants were directed to the full announcement text hosted on the NIH grants guide webpage (http://grants.nih.gov/grants/guide/pa-files/PA-14-068.html). For technical access issues, the contact provided was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
In short, PA 14-068 was designed to stimulate high-impact, mechanistic migraine research under the R01 mechanism, encourage multidisciplinary approaches that integrate biological and contextual risk factors, and accelerate translation toward novel therapeutic targets and strategies for both immediate migraine relief and long-term prevention.
FAQs: The Neurobiology of Migraine (R01) - PA 14-068
What is the Neurobiology of Migraine (R01) funding opportunity (PA 14-068)?
PA 14-068 was an NIH discretionary research grant announcement for the R01 mechanism focused on innovative, hypothesis-driven research to clarify the biological mechanisms that cause migraine, understand susceptibility differences across people, and inform better treatment and prevention strategies.
Which NIH institute led this opportunity?
The opportunity was led by the National Institute of Neurological Disorders and Stroke (NINDS), in partnership with the NIH Pain Consortium.
What type of grant mechanism did PA 14-068 use?
PA 14-068 used the NIH R01 mechanism, which is the standard investigator-initiated research project grant intended for mature, well-developed proposals with rigorous aims and methods.
What research focus did the FOA emphasize?
The FOA emphasized mechanistic migraine research that goes beyond descriptive clinical observations, with the goal of producing evidence that can translate into improved acute management and longer-term prevention strategies.
What were the main scientific goals of the announcement?
The announcement aimed to support research that (1) clarifies biological mechanisms causing migraine, (2) explains why some individuals are more susceptible than others, and (3) identifies better ways to treat and prevent migraine.
What did the FOA mean by "pushing beyond descriptive clinical observations"?
It signaled a preference for hypothesis-driven, mechanistic studies designed to produce causal or explanatory biological insights, rather than studies limited to characterizing symptoms or patterns without probing underlying mechanisms.
What kinds of biological and contextual factors were applicants expected to examine?
Projects were expected to examine how migraine arises and evolves across multiple layers of influence, including genetic factors, physiological mechanisms, biopsychosocial contributors, and environmental exposures.
What topics or systems were specifically highlighted as examples of relevant research directions?
Examples described in the FOA included: neural circuits involved in pain processing, sensory hypersensitivity, aura-related mechanisms, trigeminovascular biology, neuroimmune and inflammatory signaling, hormonal or sex-related influences, stress and comorbidity interactions, and how environmental triggers and life experiences affect risk, frequency, chronification, and disability.
Was the FOA interested in both acute and preventive migraine approaches?
Yes. The FOA highlighted discovery and validation of new therapeutic targets and exploration of potential therapies relevant to both acute migraine treatment and prevention.
Did the announcement encourage translation toward therapies?
Yes. A stated intent was to generate mechanistic evidence that can translate into improved acute management and longer-term preventive strategies, including work that could support new classes of interventions or improved use of existing approaches.
What was the activity category for this opportunity?
The activity category was Health.
Which agency sponsored the program?
The sponsor agency was the National Institutes of Health (NIH).
Was cost sharing or matching required?
No. The announcement did not require cost sharing or matching, meaning applicants were not obligated to provide non-federal funds as a condition of the award.
Who was eligible to apply?
Eligibility was broad and included many domestic and international organization types, spanning higher education, nonprofits, for-profits, and multiple levels of government entities.
Are U.S. universities and colleges eligible?
Yes. Public and private institutions of higher education were listed as eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations were eligible, including those with and without 501(c)(3) status.
Are for-profit organizations eligible?
Yes. For-profit organizations were included as eligible applicants, including small businesses and other than small businesses.
Are government entities eligible to apply?
Yes. Eligible government entities included state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are Tribal governments and Tribal organizations eligible?
Yes. The FOA explicitly welcomed applications from Tribal governments and Tribal organizations, including federally recognized Tribal governments as well as other Tribal entities.
Did the FOA include institution types like HBCUs and Hispanic-serving Institutions?
Yes. The eligibility language explicitly included institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations were included among eligible applicants.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. Non-U.S. entities were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were allowed.
When was PA 14-068 posted?
The FOA was posted on January 13, 2014.
What was the closing date for applications?
The original and current closing date listed was May 7, 2017.
Is the funding opportunity still active?
No. The FOA was archived on June 7, 2017.
Where could applicants find the full announcement text?
Applicants were directed to the NIH Grants Guide webpage for the full announcement: http://grants.nih.gov/grants/guide/pa-files/PA-14-068.html
What CFDA numbers were associated with this announcement?
The listing indicated multiple CFDA numbers tied to NIH research programs spanning neurosciences and neurological disorders and related areas, reflecting the cross-cutting relevance of migraine research across NIH priorities (including pain and neuroscience, and related intersecting areas).
Who was the contact for technical access issues?
For technical access issues, the contact provided was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What kinds of outcomes was this FOA trying to accelerate?
It aimed to accelerate high-impact mechanistic insights into migraine and speed translation toward novel therapeutic targets and strategies for immediate relief and long-term prevention, using multidisciplinary approaches that integrate biological and contextual risk factors.
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