Opportunity Information: Apply for PA 09 008
Apply for PA 09 008
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Neurodevelopment and Neuroendocrine Signaling in Adolescence Relevance to Mental Health (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Nov 27, 2009 and posted on Oct 8, 2008.
- Applicants must submit their applications by Jan 7, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Small businesses Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses City or township governments County governments Private institutions of higher education State governments Independent school districts Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity announcement PA-09-008, titled "Neurodevelopment and Neuroendocrine Signaling in Adolescence: Relevance to Mental Health (R01)," supports research aimed at clarifying how brain development and hormone-related signaling during adolescence shape emotional and cognitive maturation, and how these processes may contribute to the onset or progression of mental health problems. The central emphasis is on identifying mechanisms, meaning studies are expected to go beyond description and instead test how specific neurodevelopmental changes and neuroendocrine pathways influence behavior, cognition, affect regulation, and vulnerability to psychopathology during the adolescent period. Applications can use animal models, human participants, or a combination of both, as long as the work is clearly focused on adolescence and on links to mental health-relevant outcomes.
This opportunity uses the NIH Research Project Grant (R01) mechanism, which is generally intended for mature, hypothesis-driven projects with a well-developed research plan and a scope that can sustain multiple years of work. NIH notes that this FOA runs in parallel with a companion announcement of the same scientific scope that uses the R21 exploratory/developmental mechanism (PA-09-009). In practical terms, the R01 is the better fit for applicants who already have strong preliminary data and a detailed approach, while the parallel R21 is designed for earlier-stage, higher-risk pilot work. The scientific targets are the same across both announcements; the difference is the grant mechanism and the typical stage of project development.
Funding under PA-09-008 is described as contingent on the availability of NIH funds and on the receipt of a sufficient number of high-quality, competitive (that is, meritorious) applications. The notice does not guarantee a fixed number of awards; instead, awards depend on budget conditions and peer-review outcomes. The program sits within NIH's mental health research portfolio (CFDA 93.242, Mental Health Research Grants) and is categorized under health-related grant activity.
Eligibility is broad and includes a wide range of organization types. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (with the stated exceptions), for-profit organizations (including small businesses and other for-profits that are not small businesses), and multiple levels of government such as city or township governments, county governments, state governments, special district governments, and certain public housing authorities/Indian housing authorities. The announcement also explicitly includes groups and institutions that NIH often encourages to apply, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. Foreign (non-U.S.) entities and regional organizations are listed as eligible as well, along with U.S. territories or possessions and eligible federal agencies, underscoring that the program is open to many research settings as long as the proposed science aligns with the stated goals.
Key administrative details place the opportunity in the 2008-2010 timeframe. The FOA was posted on October 8, 2008, and is identified as archived on February 7, 2010, with a current closing date shown as January 7, 2010 (and an original closing date listed as January 7, 2012 in the source data, though the archive and current closing date indicate it is no longer active). There is no cost-sharing or matching requirement, meaning applicants are not expected to commit institutional matching funds as a condition of applying. For applicants or readers needing the full text of the announcement, NIH provided an official link to the FOA on the NIH Grants Guide website, and listed the NIH Office of Extramural Research (OER) webmaster contacts for access or technical problems.
Overall, PA-09-008 is best understood as an NIH R01 call for mechanistic research on adolescence as a sensitive developmental window, with particular attention to how neurodevelopmental trajectories and neuroendocrine signaling interact with emotional and cognitive development to influence risk for mental disorders. The FOA encourages rigorous work that can connect biological processes to developmental outcomes and emerging psychopathology, using appropriately chosen animal and/or human approaches to answer questions that are directly relevant to mental health.
Frequently Asked Questions (FAQs)
What is the funding opportunity PA-09-008?
PA-09-008 is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) titled "Neurodevelopment and Neuroendocrine Signaling in Adolescence: Relevance to Mental Health (R01)." It supports research that clarifies how adolescent brain development and hormone-related (neuroendocrine) signaling shape emotional and cognitive maturation, and how these processes may contribute to the onset or progression of mental health problems.
What is the main scientific focus of this FOA?
The central emphasis is on identifying mechanisms. Studies are expected to go beyond describing developmental changes and instead test how specific neurodevelopmental changes and neuroendocrine pathways influence behavior, cognition, affect regulation, and vulnerability to psychopathology during adolescence.
Why does the FOA emphasize "mechanisms" instead of descriptive studies?
Based on the FOA description, NIH is prioritizing research that can explain how and why adolescent neurodevelopmental and neuroendocrine processes influence mental health-relevant outcomes. That means proposals should be designed to test relationships and pathways (for example, how a defined developmental change or hormone-related signaling route affects cognition, emotion regulation, or risk for mental disorders), rather than only documenting that changes occur.
What types of research models are allowed (human, animal, or both)?
Applications may use animal models, human participants, or a combination of both. The key requirement is that the work is clearly focused on adolescence and on links to outcomes relevant to mental health.
Does the proposed research have to focus specifically on adolescence?
Yes. The FOA is framed around adolescence as a sensitive developmental window. The proposed science needs to be clearly focused on adolescence and its connection to emotional and cognitive maturation and/or vulnerability to psychopathology.
What grant mechanism is used for PA-09-008?
This FOA uses the NIH Research Project Grant (R01) mechanism. The R01 is generally intended for mature, hypothesis-driven projects with a well-developed research plan and a scope that can sustain multiple years of work.
Is there a related NIH opportunity for exploratory or pilot projects?
Yes. NIH notes this FOA runs in parallel with a companion announcement of the same scientific scope using the R21 exploratory/developmental mechanism (PA-09-009). The scientific targets are the same; the difference is the grant mechanism and the typical stage of project development.
How should an applicant decide between the R01 (PA-09-008) and the companion R21 (PA-09-009)?
Based on the FOA description, the R01 is typically a better fit for applicants who already have strong preliminary data and a detailed approach. The parallel R21 is designed for earlier-stage, higher-risk pilot work. The scientific scope is the same across both announcements.
What kinds of outcomes or endpoints are relevant to this FOA?
The FOA highlights outcomes such as behavior, cognition, affect regulation, and vulnerability to psychopathology during adolescence. Research should connect adolescent neurodevelopment and neuroendocrine signaling to mental health-relevant developmental outcomes and/or emerging mental health problems.
Is funding guaranteed under this FOA?
No. Funding is described as contingent on the availability of NIH funds and on the receipt of a sufficient number of high-quality, competitive (meritorious) applications. The FOA does not guarantee a fixed number of awards; awards depend on budget conditions and peer-review outcomes.
What is the associated CFDA program for this opportunity?
The FOA sits within NIH's mental health research portfolio and is associated with CFDA 93.242, Mental Health Research Grants.
What types of organizations are eligible to apply?
Eligibility is broad. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (with or without 501(c)(3) status, with stated exceptions), for-profit organizations (including small businesses and other for-profits that are not small businesses), and multiple levels of government (city or township, county, state, special district), as well as certain public housing authorities/Indian housing authorities.
Are minority-serving institutions and community-based organizations included as eligible applicants?
Yes. The FOA explicitly includes organizations NIH often encourages to apply, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Are foreign (non-U.S.) entities eligible to apply?
Yes. Foreign (non-U.S.) entities and regional organizations are listed as eligible, and the eligibility list also includes U.S. territories or possessions and eligible federal agencies.
Is cost-sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement, meaning applicants are not expected to provide institutional matching funds as a condition of applying.
When was this FOA posted and what is its status?
The FOA was posted on October 8, 2008. It is identified as archived on February 7, 2010. A current closing date is shown as January 7, 2010. While the source data also lists an original closing date of January 7, 2012, the archived status and the current closing date indicate the opportunity is no longer active.
Where can someone find the official FOA text?
NIH provided an official link to the FOA on the NIH Grants Guide website.
Who is listed as the contact for technical issues accessing the announcement?
The NIH Office of Extramural Research (OER) webmaster contacts are listed for access or technical problems related to the FOA text.
What is the overall purpose of PA-09-008 in practical terms?
Overall, PA-09-008 is an NIH R01 call for mechanistic research that treats adolescence as a sensitive developmental window. It prioritizes studies that connect neurodevelopmental trajectories and neuroendocrine signaling with emotional and cognitive development, and that clarify how these processes influence risk for mental disorders.
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