Opportunity Information: Apply for PA 13 338
Apply for PA 13 338
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Neuroscience Research on Drug Abuse (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Aug 26, 2013 and posted on Aug 26, 2013.
- Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses State governments Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Private institutions of higher education Special district governments Independent school districts For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Neuroscience Research on Drug Abuse (R01) funding opportunity (PA 13-338) was a National Institutes of Health (NIH) discretionary grant program focused on advancing neuroscience-based understanding of drug abuse and addiction. The core premise is that substance use produces broad and sometimes lasting changes in brain structure and brain function, and that research is needed to explain how those neurobiological changes translate into altered behavior. In practical terms, the opportunity aimed to support studies that clarify what happens in the brain during key stages of addiction, particularly chronic drug exposure, withdrawal, and relapse, since these phases are often where long-term compulsive use and return-to-use patterns become biologically entrenched.
The scientific goals emphasized identifying and explaining neurobiological mechanisms that underlie drug abuse and addiction. That includes mapping and characterizing drug-related changes in neural circuits, signaling systems, synaptic plasticity, and other brain processes that can drive reinforcement, craving, impaired decision-making, stress sensitivity, and compulsive drug seeking. The program also highlighted why this mechanistic work matters: by understanding the basic biology of addiction, researchers can point to concrete molecular, cellular, circuit-level, or behavioral targets that may ultimately inform prevention strategies and treatment interventions. In other words, it was not limited to describing effects of drugs on the brain, but encouraged research that helps explain cause-and-effect relationships and identifies leverage points for intervention.
The FOA explicitly welcomed a wide range of methodological approaches, reflecting the complexity of addiction neuroscience. Basic research was considered appropriate, such as studies in animal models or cellular systems that probe mechanisms of neuroadaptation. Translational research was also within scope, meaning work designed to bridge findings from basic neuroscience toward human relevance, including biomarker development, validation of targets, or studies that connect circuit-level changes to clinically meaningful outcomes. Clinical approaches were also encouraged, which could include human neuroimaging, neurocognitive assessments, clinical neuroscience studies of withdrawal and relapse risk, or other patient-oriented research that tests or refines mechanistic hypotheses in people. The unifying requirement was that the work meaningfully advanced understanding of the neuroscience of drug abuse and addiction, especially around chronic use, withdrawal, and relapse processes.
Administratively, this opportunity used the NIH R01 funding instrument, which is the standard Research Project Grant mechanism typically used for investigator-initiated, hypothesis-driven projects with a defined research plan. The program fell under the health funding activity category and was associated with CFDA number 93.279 (Drug Abuse and Addiction Research Programs). No cost sharing or matching was required, which is consistent with many NIH research grants.
Eligibility was broad and included many types of U.S. and non-U.S. institutions and organizations. Eligible applicants included public and private institutions of higher education, public/state-controlled institutions, nonprofit organizations (both 501(c)(3) and non-501(c)(3) categories), small businesses, and for-profit organizations other than small businesses. Government entities at the state, county, city/township, special district, and independent school district levels were listed as eligible, as were public housing authorities and various tribal governments and tribal organizations. The FOA also specified additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations and eligible federal agencies. Importantly, foreign participation was allowed: non-U.S. entities (foreign organizations and foreign institutions) could apply, non-U.S. components of U.S. organizations were eligible, and foreign components as defined by NIH policy were permitted.
Key dates show that the FOA was posted and created on August 26, 2013, with an original and final closing date of January 7, 2017, and an archive date of February 7, 2017, meaning it is no longer an active solicitation in that exact form. The official program materials were hosted by NIH on the grants.nih.gov site under the PA 13-338 announcement page. For access or technical issues, the provided contact point was the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs): Neuroscience Research on Drug Abuse (R01) - PA 13-338
What is the Neuroscience Research on Drug Abuse (R01) opportunity (PA 13-338)?
PA 13-338 was a National Institutes of Health (NIH) discretionary funding opportunity using the R01 Research Project Grant mechanism. It focused on advancing neuroscience-based understanding of drug abuse and addiction, with emphasis on how substance use can produce broad and sometimes lasting changes in brain structure and function, and how those changes translate into altered behavior.
What was the main purpose of this funding opportunity?
The purpose was to support research that identifies and explains neurobiological mechanisms underlying drug abuse and addiction, particularly mechanisms involved in chronic drug exposure, withdrawal, and relapse. The goal was to strengthen cause-and-effect understanding of addiction-related brain changes and to help point toward targets that could ultimately inform prevention and treatment strategies.
Which stages of addiction were specifically emphasized?
The opportunity particularly emphasized research on key stages where long-term patterns can become biologically entrenched: chronic drug exposure, withdrawal, and relapse.
What kinds of scientific questions fit within the scope of PA 13-338?
Projects within scope included studies that map and characterize drug-related changes in the brain and explain how those changes drive addiction-relevant outcomes. Examples of the types of mechanisms highlighted include changes in neural circuits, signaling systems, synaptic plasticity, and other brain processes that can influence reinforcement, craving, impaired decision-making, stress sensitivity, and compulsive drug seeking.
Was the program limited to describing drug effects on the brain?
No. The program encouraged work that goes beyond describing effects and instead clarifies mechanisms, supports cause-and-effect explanations, and identifies leverage points (molecular, cellular, circuit-level, or behavioral targets) that could inform prevention strategies and treatment interventions.
What research approaches were welcomed?
A wide range of approaches was explicitly welcomed, including basic, translational, and clinical neuroscience approaches, as long as the work meaningfully advanced understanding of the neuroscience of drug abuse and addiction (especially around chronic use, withdrawal, and relapse).
Did the FOA allow basic research?
Yes. Basic research was considered appropriate, including studies using animal models or cellular systems to probe mechanisms of neuroadaptation and other foundational neuroscience questions related to drug abuse and addiction.
Did the FOA allow translational research?
Yes. Translational research designed to bridge basic neuroscience toward human relevance was within scope. Examples mentioned include biomarker development, validation of targets, and studies connecting circuit-level changes to clinically meaningful outcomes.
Did the FOA allow clinical or human-subject research?
Yes. Clinical approaches were encouraged and could include human neuroimaging, neurocognitive assessments, clinical neuroscience studies of withdrawal and relapse risk, or other patient-oriented research that tests or refines mechanistic hypotheses in people.
What funding mechanism was used?
This opportunity used the NIH R01 mechanism (Research Project Grant), a standard mechanism typically used for investigator-initiated, hypothesis-driven projects with a defined research plan.
What is the CFDA number associated with this program?
The program was associated with CFDA number 93.279, labeled "Drug Abuse and Addiction Research Programs."
Was cost sharing or matching required?
No. The opportunity stated that no cost sharing or matching was required.
Who was eligible to apply?
Eligibility was broad and included many U.S. and non-U.S. institutions and organizations. Eligible applicants included public and private institutions of higher education; public/state-controlled institutions; nonprofit organizations (both 501(c)(3) and non-501(c)(3)); small businesses; and for-profit organizations other than small businesses.
Were government entities eligible applicants?
Yes. Eligible government entities included state, county, and city/township governments; special district governments; and independent school districts. Public housing authorities were also listed as eligible.
Were tribal governments and tribal organizations eligible?
Yes. The FOA listed various tribal governments and tribal organizations as eligible applicant types.
Were minority-serving institutions explicitly included?
Yes. The FOA specified eligibility for several categories of minority-serving institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Were faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations were listed as eligible applicants.
Were eligible federal agencies allowed to apply?
Yes. Eligible federal agencies were included among the eligible applicant types.
Was foreign participation allowed?
Yes. Foreign participation was allowed. Non-U.S. entities (foreign organizations and foreign institutions) could apply, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were permitted.
Is PA 13-338 still open for applications?
No. The opportunity is no longer active in that exact form. The FOA was created/posted on August 26, 2013, had an original and final closing date of January 7, 2017, and an archive date of February 7, 2017.
Where were the official program materials posted?
The official materials were hosted by NIH on the grants.nih.gov website under the PA 13-338 announcement page.
Who was listed as the contact for access or technical issues?
The provided contact for access or technical issues was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What type of funding category did this fall under?
The opportunity was described as part of a health funding activity category.
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