Opportunity Information: Apply for PA 13 337

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Neuroscience Research on Drug Abuse (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
  • This funding opportunity was created on Aug 26, 2013 and posted on Aug 26, 2013.
  • Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Special district governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Independent school districts County governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) City or township governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The National Institutes of Health (NIH) grant opportunity titled "Neuroscience Research on Drug Abuse (R21)" (Funding Opportunity Number PA 13 337) supported short, exploratory research projects aimed at understanding how substance abuse changes the brain and how those changes influence behavior. The central focus was on the neurobiological mechanisms that drive drug abuse and addiction, with particular emphasis on what happens in the brain during chronic drug exposure, the withdrawal period, and relapse. The rationale behind the program was that addiction is associated with widespread alterations in brain structure and function, and that clarifying these underlying mechanisms can reveal concrete biological targets for improved prevention strategies and more effective treatments.

This funding announcement encouraged a wide range of neuroscience approaches as long as they advanced understanding of addiction-related brain processes. Projects could be basic (for example, studies of neural circuits, synaptic plasticity, neurotransmitter systems, or molecular and cellular adaptations caused by repeated drug exposure), translational (bridging lab findings toward practical interventions, biomarkers, or clinically relevant models), or clinical (studies in humans that examine brain function, behavior, or treatment-relevant neurobiology). Overall, the opportunity was designed to support research that explains how addiction develops and persists in the brain, why relapse risk remains high even after periods of abstinence, and how those processes might be interrupted.

The award mechanism was an NIH R21, which is typically used for early-stage, high-impact, and exploratory projects that can generate key feasibility data or open new lines of investigation. The listed award ceiling was $200,000, and there was no cost sharing or matching requirement. In terms of administrative classification, it was a discretionary grant opportunity in the health and education funding activity category, listed under CFDA number 93.279 (Drug Abuse and Addiction Research Programs).

Eligibility was broad and included many types of U.S. organizations such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), small businesses, for-profit organizations other than small businesses, state and local governments (including county and city/township governments), independent school districts, special district governments, and public housing authorities/Indian housing authorities. It also explicitly included tribal entities and tribal-serving institutions, such as federally recognized Native American tribal governments, other tribal organizations, and tribally controlled colleges and universities. The announcement further extended eligibility to a range of designated institutions (including HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions), as well as faith-based and community-based organizations, eligible federal agencies, U.S. territories or possessions, and regional organizations. Importantly, non-U.S. entities were eligible to apply, including foreign organizations and foreign institutions, and foreign components were allowed under NIH policy, including non-U.S. components of U.S. organizations.

Key dates indicate the opportunity was posted and created on Aug 26, 2013, with the original and current closing date listed as Jan 7, 2017, and an archive date of Feb 7, 2017. Additional details and the full program announcement were available through NIH at http://grants.nih.gov/grants/guide/pa-files/PA-13-337.html. For access or technical issues related to the announcement, the listed point of contact was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

Frequently Asked Questions (FAQs): NIH "Neuroscience Research on Drug Abuse (R21)" (PA-13-337)

What is the title and funding opportunity number for this grant?

The opportunity is titled "Neuroscience Research on Drug Abuse (R21)" and the Funding Opportunity Number is PA-13-337.

Which agency offers this funding opportunity?

This program announcement is offered by the National Institutes of Health (NIH).

What is the overall purpose of this grant opportunity?

The purpose is to support short, exploratory neuroscience research projects that improve understanding of how substance abuse changes the brain and how those brain changes influence behavior, particularly in ways that contribute to drug abuse and addiction.

What is the central scientific focus of the program?

The central focus is on neurobiological mechanisms that drive drug abuse and addiction, with emphasis on brain processes during chronic drug exposure, the withdrawal period, and relapse.

Why does NIH emphasize brain mechanisms in addiction research under this opportunity?

The rationale described in the announcement is that addiction is associated with widespread alterations in brain structure and function. By clarifying underlying mechanisms, research can reveal concrete biological targets that may improve prevention strategies and lead to more effective treatments.

What kinds of research approaches were encouraged?

A wide range of neuroscience approaches were encouraged, as long as they advanced understanding of addiction-related brain processes. The announcement supported basic, translational, and clinical neuroscience studies.

What are examples of basic research topics that fit this opportunity?

Examples given include studies of neural circuits, synaptic plasticity, neurotransmitter systems, and molecular or cellular adaptations caused by repeated drug exposure.

What does "translational" mean in the context of this announcement?

Translational research, as described here, includes work that bridges laboratory findings toward practical interventions, biomarkers, or clinically relevant models related to addiction.

Are clinical (human) studies allowed?

Yes. The announcement explicitly includes clinical studies in humans that examine brain function, behavior, or treatment-relevant neurobiology.

What stages of addiction does the program particularly emphasize?

The opportunity places particular emphasis on what happens in the brain during chronic drug exposure, the withdrawal period, and relapse.

What kinds of questions is the program designed to help answer?

It is designed to support research that explains how addiction develops and persists in the brain, why relapse risk remains high even after periods of abstinence, and how those processes might be interrupted.

What grant mechanism is used for this funding opportunity?

The award mechanism is an NIH R21.

What type of projects is an NIH R21 intended to support?

As described in the opportunity, the R21 mechanism is typically used for early-stage, high-impact, and exploratory projects that can generate key feasibility data or open new lines of investigation.

What is the listed award ceiling?

The listed award ceiling is $200,000.

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

How is this opportunity classified administratively?

It is described as a discretionary grant opportunity in the health and education funding activity category.

What CFDA number is associated with this opportunity?

The CFDA number listed is 93.279 (Drug Abuse and Addiction Research Programs).

Who is eligible to apply?

Eligibility is broad and includes many types of U.S. organizations, including institutions of higher education (public/state-controlled and private), nonprofit organizations (501(c)(3) and non-501(c)(3)), small businesses, and for-profit organizations other than small businesses.

Are state and local governments eligible?

Yes. The opportunity includes eligibility for state governments and local governments, including county governments and city/township governments.

Are school districts and special districts eligible?

Yes. Independent school districts and special district governments are listed as eligible.

Are public housing authorities eligible?

Yes. Public housing authorities/Indian housing authorities are included in the eligibility list.

Are tribal entities and tribal-serving institutions eligible?

Yes. The announcement explicitly includes federally recognized Native American tribal governments, other tribal organizations, and tribally controlled colleges and universities.

Are designated institutions such as HBCUs and Hispanic-serving institutions eligible?

Yes. The eligibility description includes designated institutions such as HBCUs, Hispanic-serving institutions, AANAPISIs, and Alaska Native and Native Hawaiian Serving Institutions.

Are faith-based and community-based organizations eligible?

Yes. Faith-based and community-based organizations are explicitly included among eligible applicants.

Can federal agencies apply?

Yes. Eligible federal agencies are included in the eligibility list.

Are U.S. territories or possessions eligible?

Yes. U.S. territories or possessions are included as eligible applicants.

Are regional organizations eligible?

Yes. Regional organizations are included in the eligibility list.

Can non-U.S. entities apply?

Yes. The announcement states that non-U.S. entities are eligible to apply, including foreign organizations and foreign institutions.

Are foreign components allowed?

Yes. Foreign components are allowed under NIH policy, including non-U.S. components of U.S. organizations.

When was the opportunity posted and created?

The key dates indicate the opportunity was posted and created on Aug 26, 2013.

What was the closing date for applications?

The original and current closing date listed is Jan 7, 2017.

When was the opportunity archived?

The archive date listed is Feb 7, 2017.

Where can applicants find the full program announcement?

The full program announcement was available through NIH at: http://grants.nih.gov/grants/guide/pa-files/PA-13-337.html

Who should be contacted for access or technical issues with the announcement page?

For access or technical issues related to the announcement, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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