New Approaches to Arrhythmia Detection and Treatment (STTR R41/R42) | Apply Online

Opportunity Summary:

The National Institutes of Health (NIH) funding opportunity titled "New Approaches to Arrhythmia Detection and Treatment (STTR R41/R42)" (Funding Opportunity Number PA-07-031) supports small businesses working on new technologies and approaches to detect, monitor, and treat cardiac arrhythmias. The program is offered as a discretionary grant under the NIH cardiovascular research portfolio (CFDA 93.837, Cardiovascular Diseases Research). The intent is to move promising arrhythmia-related innovations from early feasibility work toward more advanced development, with the overall focus on practical solutions that could improve how abnormal heart rhythms are identified and managed.

This announcement uses the Small Business Technology Transfer (STTR) mechanisms, specifically R41 (Phase I) and R42 (Phase II), and it also allows Fast-Track applications that combine Phase I and Phase II in a single submission for projects that are ready to move quickly from feasibility to development. A key feature of STTR is the required collaboration between a U.S. small business concern (SBC) and a non-profit research institution, helping translate academic or institutional expertise into commercially viable medical products or services. The announcement notes it runs in parallel with a companion funding opportunity (PA-07-032) that has identical scientific scope but uses the SBIR mechanisms (R43/R44), which generally have different collaboration requirements. In practice, this means applicants should choose the mechanism that best matches their development plan and organizational structure while pursuing the same general scientific goals in arrhythmia innovation.

Eligibility is limited to U.S. small business concerns. The small business must meet all SBC criteria at the time of award for both Phase I and Phase II, as defined in the eligibility section of the full announcement. Foreign institutions are explicitly not eligible to apply. The listing also indicates "Others (see text field entitled Additional Information on Eligibility for clarification)," which typically reflects the STTR partnership structure where the applicant is the SBC, but the work is shared with an eligible U.S. research institution under the STTR rules.

There is no cost sharing or matching requirement stated for this opportunity, which is important for early-stage companies that may not have significant non-federal funds available. However, awards are not guaranteed: NIH makes clear that funding depends on the availability of funds and the receipt of a sufficient number of scientifically and technically strong applications. Like most NIH programs, this implies competitive peer review, with awards going to proposals judged meritorious relative to others in the applicant pool and aligned with program priorities.

The opportunity was posted on November 3, 2006, and later shows a creation date of January 26, 2009, with multiple receipt dates rather than a single deadline. That structure usually means the program accepted applications at several standard NIH submission cycles over its open period. The archive date is listed as January 5, 2010, indicating the announcement is no longer active, but it remains a useful reference point for understanding NIH priorities and the STTR pathway for arrhythmia-related product development during that period.

For applicants or readers looking for the authoritative details, the full announcement link is provided (http://grants.nih.gov/grants/guide/pa-files/PA-07-031.html). NIH also lists support contacts through the NIH Office of Extramural Research (OER) webmaster emails for assistance accessing or linking to the announcement (FBOWebmaster@OD.NIH.GOV), which is mainly helpful for technical access issues rather than scientific questions.

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Next opportunity: New Approaches to Arrhythmia Detection and Treatment (SBIR R43/R44)

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