Opportunity Information: Apply for PAS 15 168

  • The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "New Directions in Hematology Research (SHINE II) (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
  • This funding opportunity was created on Apr 1, 2015 and posted on Apr 1, 2015.
  • Applicants must submit their applications by May 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: State governments City or township governments Independent school districts For profit organizations other than small businesses Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) County governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

New Directions in Hematology Research (SHINE II) (R01) is an NIH grant opportunity from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) designed to push hematology research into fresh, high impact territory. The goal is to encourage investigator initiated projects that test genuinely new ideas in ways that can quickly show whether a concept is worth pursuing on a larger scale. In practice, this means the program is looking for basic or preclinical, proof of principle studies that are tightly focused and aimed at validating novel concepts, tools, or approaches that could open up new avenues for discovery relevant to NIDDKs hematology mission.

A key feature of this FOA is that applications are expected to be smaller and more targeted than a standard R01. Instead of broad multi aim projects, proposals should center on a single main aim and be designed to deliver a clear, decisive result about feasibility or biological plausibility. The time horizon is also compressed compared with typical R01s, with projects expected to run about 1 to 3 years. The underlying emphasis is on speed, focus, and innovation: the type of work that can de risk an untested direction, generate the critical data needed to justify a bigger program, or demonstrate that a new idea can work well enough to change how a field thinks about a problem.

From an administrative standpoint, this is a discretionary grant program under Funding Opportunity Number PAS 15 168, posted April 1, 2015. The total estimated funding listed is about $1,000,000, and the award ceiling is $200,000. Cost sharing or matching is not required, which generally lowers the barrier for institutions and investigators who might not have discretionary funds available to support the work alongside federal dollars. The FOA remained open until May 7, 2018, and it was archived June 7, 2018, meaning it is no longer active for new submissions, but it still serves as a reference point for the structure and intent of the SHINE II mechanism.

Eligibility is broad and includes many types of domestic organizations and government entities. Eligible applicants include public and state controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, for profit organizations other than small businesses, and small businesses. Various levels of government are also eligible, including state governments, county governments, city or township governments, special district governments, and certain housing authorities. The eligibility language also calls out a range of mission focused institutions and community based organizations that NIH often encourages to apply, including Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith based or community based organizations and eligible federal agencies. In terms of international participation, non U.S. entities and non U.S. components of U.S. organizations are not eligible to apply directly, but foreign components as defined by NIH policy are allowed, which can matter when a U.S. led project needs a specific overseas collaboration, resource, or expertise.

The administering agency is the National Institutes of Health, and the program is categorized in the listing under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), reflecting NIDDK stewardship even though the scientific focus here is hematology. Anyone needing the original archived announcement can find it through the NIH Grants Guide page associated with PAS 15 168. For access or technical linking issues, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

Frequently Asked Questions (FAQs): New Directions in Hematology Research (SHINE II) (R01) - PAS 15 168

What is the New Directions in Hematology Research (SHINE II) (R01) opportunity?

New Directions in Hematology Research (SHINE II) (R01) is an NIH grant opportunity from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It is intended to push hematology research into fresh, high-impact territory by supporting investigator-initiated projects that test genuinely new ideas and can quickly show whether a concept is worth pursuing at a larger scale.

Which NIH Institute is sponsoring and stewarding this program?

The program is sponsored by the National Institutes of Health (NIH) and is stewarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), even though the scientific focus is hematology.

What is the main goal of SHINE II?

The goal is to encourage basic or preclinical proof-of-principle studies that are tightly focused on validating novel concepts, tools, or approaches relevant to NIDDK's hematology mission. The emphasis is on speed, focus, and innovation.

What type of research is this FOA looking for?

This FOA is looking for basic or preclinical, proof-of-principle studies. Projects should be designed to validate new concepts, tools, or approaches and generate clear evidence about feasibility or biological plausibility.

How is this different from a standard R01?

Applications are expected to be smaller and more targeted than a standard R01. Rather than proposing broad multi-aim projects, SHINE II proposals should center on a single main aim and be structured to deliver a clear, decisive result about whether the new direction is viable.

How many specific aims should an application have under this FOA?

Based on the FOA description, proposals should center on a single main aim rather than multiple broad aims.

How long are SHINE II projects expected to run?

The time horizon is compressed compared with typical R01s. Projects are expected to run about 1 to 3 years.

What is the funding opportunity number for SHINE II?

The Funding Opportunity Number is PAS 15 168.

When was this FOA posted, and is it still open for applications?

The FOA was posted on April 1, 2015. It remained open until May 7, 2018, and it was archived on June 7, 2018. Because it is archived, it is no longer active for new submissions.

If the FOA is archived, does it still have any value?

Yes. While it is not active for new submissions, it can still serve as a reference point for the structure and intent of the SHINE II mechanism.

What is the total estimated funding available under this opportunity?

The total estimated funding listed is about $1,000,000.

What is the award ceiling for an individual grant under this FOA?

The award ceiling is $200,000.

Is cost sharing or matching required?

No. Cost sharing or matching is not required.

Who is eligible to apply?

Eligibility is broad and includes many types of domestic organizations and government entities, including:

  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • Nonprofits with 501(c)(3) status
  • Nonprofits without 501(c)(3) status
  • For-profit organizations other than small businesses
  • Small businesses
  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Certain housing authorities
  • Eligible federal agencies

Are mission-focused and community-based institutions specifically encouraged or included?

Yes. The eligibility language calls out several types of institutions and organizations NIH often encourages to apply, including HBCUs, Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations.

Can a non-U.S. organization apply directly?

No. Non-U.S. entities and non-U.S. components of U.S. organizations are not eligible to apply directly under this FOA.

Are foreign components allowed at all?

Yes. Foreign components (as defined by NIH policy) are allowed. This can be relevant when a U.S.-led project needs a specific overseas collaboration, resource, or expertise.

Which agency administers this grant program?

The administering agency is the National Institutes of Health (NIH).

What CFDA listing is associated with this FOA?

The program is listed under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).

Where can someone find the original archived announcement?

The original archived announcement can be found through the NIH Grants Guide page associated with PAS 15 168.

Who should be contacted for access or technical linking issues with the archived announcement?

For access or technical linking issues, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

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