Opportunity Information: Apply for RFA GM 13 002
Apply for RFA GM 13 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "New Methods for Understanding the Functional Role of Human DNA Sequence Variants in Complex Phenotypes (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Dec 1, 2011 and posted on Dec 1, 2011.
- Applicants must submit their applications by Feb 17, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments County governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities For profit organizations other than small businesses State governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH National Institute of General Medical Sciences (NIGMS) released this R01 grant opportunity, titled "New Methods for Understanding the Functional Role of Human DNA Sequence Variants in Complex Phenotypes (R01)," to support research that develops and applies new experimental and computational methods for figuring out what human DNA sequence variants actually do. The central aim is to move beyond simply identifying variants associated with traits or disease risk and instead determine which variants are functionally relevant, how they exert their effects, and how they contribute to complex phenotypes that are influenced by many genetic and non-genetic factors. In practical terms, the FOA is looking for projects that can connect genetic variation to biological mechanisms, such as changes in gene regulation, protein function, cellular pathways, or broader system-level behavior.
This opportunity was published as a discretionary grant under the NIH R01 mechanism (Funding Opportunity Number RFA-GM-13-002) and falls under the health-related biomedical research and research training area (CFDA 93.859). The announcement was posted on December 1, 2011, with an application due date of February 17, 2012, and it was later archived on March 19, 2012. The estimated total funding level listed for the program is $3,000,000, and there is no cost sharing or matching requirement, meaning applicants are not expected to provide institutional or third-party matching funds as a condition of receiving an award.
From a scientific scope standpoint, the FOA emphasizes approaches that can interpret the functional consequences of DNA sequence differences in humans, especially in the context of complex traits where the effect of any single variant may be modest, context-dependent, or mediated through regulatory networks rather than simple changes to coding sequence. Because the notice explicitly calls for both experimental and computational approaches, competitive proposals would typically be expected to include method development, validation, and demonstration of utility. That might mean new assays for measuring variant effects at scale, improved strategies for prioritizing candidate causal variants, novel statistical or machine-learning frameworks for predicting functional impact, or integrated pipelines that combine genomics data types with mechanistic experimentation. The overall direction is strongly aligned with bridging the gap between association signals and biological interpretation.
Eligibility for this FOA is broad and includes a wide range of domestic U.S. organizations: public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), small businesses, for-profit organizations (other than small businesses), independent school districts, and multiple levels of government (state governments, county governments, city or township governments, special district governments), as well as public housing authorities and Indian housing authorities. It also includes Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments). In addition, the eligibility language explicitly extends to a variety of institution types often highlighted for inclusion, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, and U.S. territories or possessions and regional organizations.
Notably, the FOA allows participation by non-U.S. entities. Non-domestic (non-U.S.) institutions are eligible to apply, non-domestic components of U.S. organizations may be included, and foreign components are allowed as defined in the NIH Grants Policy Statement. This matters for projects where key populations, data resources, specialized expertise, or unique experimental capabilities are located outside the United States, and it signals that NIGMS was open to internationally anchored collaborations as long as the scientific justification and compliance requirements are met.
Administratively, the sponsoring agency is the National Institutes of Health, with NIGMS as the issuing institute. Applicants were directed to the full announcement hosted on the NIH grants site, and the provided contact point in the source information is the NIH Office of Extramural Research (OER) webmaster email for technical issues accessing or linking to the FOA. For the complete official requirements, application instructions, and any special review considerations, the FOA points to the detailed NIH posting at the provided URL (http://grants.nih.gov/grants/guide/rfa_files/RFA-GM-13-002.html).
Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The funding opportunity is titled "New Methods for Understanding the Functional Role of Human DNA Sequence Variants in Complex Phenotypes (R01)."
Which NIH institute released this opportunity?
The opportunity was released by the NIH National Institute of General Medical Sciences (NIGMS).
What grant mechanism does this opportunity use?
This opportunity uses the NIH R01 research project grant mechanism.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-GM-13-002.
What is the main purpose of this FOA?
The central purpose is to support research that develops and applies new experimental and computational methods to determine what human DNA sequence variants actually do, especially in the context of complex phenotypes. The goal is to move beyond identifying variants associated with traits or disease risk and instead determine which variants are functionally relevant, how they exert their effects, and how they contribute to phenotypes influenced by many genetic and non-genetic factors.
What kinds of research approaches does the FOA emphasize?
The FOA emphasizes both experimental and computational approaches for interpreting the functional consequences of human DNA sequence differences. It highlights methods that can connect genetic variation to biological mechanisms such as changes in gene regulation, protein function, cellular pathways, or system-level behavior.
Does this FOA focus only on coding variants?
No. The scope explicitly includes complex traits where effects may be modest, context-dependent, or mediated through regulatory networks rather than straightforward changes to coding sequence.
What types of project components would typically be expected in a competitive application (based on the FOA description)?
Based on the description, competitive projects would typically involve method development, validation, and demonstration of utility. Examples mentioned include new assays for measuring variant effects at scale, improved strategies for prioritizing candidate causal variants, new statistical or machine-learning frameworks to predict functional impact, or integrated pipelines combining genomics data types with mechanistic experimentation.
What does "bridging the gap between association signals and biological interpretation" mean in this context?
In this FOA, it refers to moving from statistical associations between variants and traits to an understanding of biological mechanisms, including identifying which variants are causal or functionally relevant and describing how they influence molecular or cellular processes that contribute to complex phenotypes.
What is the CFDA number and program area listed for this opportunity?
The CFDA number is 93.859, and it is listed under health-related biomedical research and research training.
What is the estimated total funding level for the program?
The estimated total funding level listed is $3,000,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
When was the FOA posted?
The announcement was posted on December 1, 2011.
What was the application due date?
The application due date was February 17, 2012.
Is this FOA still active?
No. The FOA was archived on March 19, 2012.
Who is eligible to apply from the United States?
Eligibility is broad and includes U.S. public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); small businesses; for-profit organizations (other than small businesses); independent school districts; state, county, and city/township governments; special district governments; public housing authorities; Indian housing authorities; federally recognized Native American tribal governments; and tribal organizations (other than federally recognized tribal governments).
Are organizations like HBCUs, Hispanic-serving institutions, and TCCUs included in eligibility?
Yes. The eligibility language explicitly includes institution types often highlighted for inclusion, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, and organizations in U.S. territories or possessions and regional organizations.
Are non-U.S. (foreign) organizations allowed to apply?
Yes. Non-domestic (non-U.S.) institutions are eligible to apply.
Can a U.S. organization include a non-U.S. component in the project?
Yes. Non-domestic components of U.S. organizations may be included, and foreign components are allowed as defined in the NIH Grants Policy Statement.
Why might foreign components matter for this FOA?
The FOA notes that this can be important when key populations, data resources, specialized expertise, or unique experimental capabilities are located outside the United States, enabling internationally anchored collaborations when scientifically justified and compliant with NIH requirements.
Who is the sponsoring agency for this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), with NIGMS as the issuing institute.
Where can applicants find the official FOA posting?
The FOA is hosted on the NIH grants site at: http://grants.nih.gov/grants/guide/rfa_files/RFA-GM-13-002.html
Who is listed as the contact for technical issues accessing or linking to the FOA?
The provided contact point is the NIH Office of Extramural Research (OER) webmaster email, listed for technical issues related to accessing or linking to the announcement.
Where should applicants look for official requirements and instructions?
For complete official requirements, application instructions, and any special review considerations, applicants were directed to the detailed NIH posting at the FOA URL.
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