Opportunity Information: Apply for RFA NS 13 005
Apply for RFA NS 13 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "New Projects for Epi4K Genetics and Genomics of Human Epilepsies Center without Walls (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Jul 13, 2012 and posted on Jul 13, 2012.
- Applicants must submit their applications by Dec 18, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Public housing authorities/Indian housing authorities Special district governments State governments Public and State controlled institutions of higher education Private institutions of higher education County governments Small businesses Native American tribal governments (Federally recognized) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity RFA-NS-13-005, titled "New Projects for Epi4K Genetics and Genomics of Human Epilepsies Center without Walls (U01)," was a discretionary, cooperative agreement program designed to bring additional investigators and datasets into the existing Epi4K "Center without Walls" (CWOW) collaborative network. The central goal was to expand epilepsy gene discovery by supporting projects that could plug into Epi4K infrastructure and accelerate the identification of genetic contributors to human epilepsy, especially through modern high-throughput sequencing approaches. Because this is a U01 mechanism, funded teams were expected to work closely with the NIH and the Epi4K CWOW, with an emphasis on coordinated project management, shared standards, and integration of results into the broader consortium efforts rather than operating as a fully independent R01-style project.
The FOA specifically targeted investigators who already had DNA sample collections drawn from well-characterized cohorts of epilepsy patients. In practical terms, this meant applicants needed to start from a strong clinical and phenotypic foundation: clearly defined epilepsy syndromes or seizure phenotypes, robust accompanying clinical data, and existing biospecimens suitable for genomic work. The work proposed under this opportunity was expected to use next generation sequencing and associated analytic pipelines to discover novel sequence variants and copy number variants that may contribute to epilepsy risk, epilepsy subtype, or related neurodevelopmental outcomes. The scientific focus was therefore on discovery genetics and genomics, leveraging technologies such as exome sequencing, genome sequencing, or other NGS-based strategies, paired with computational analysis aimed at variant calling, interpretation, and prioritization.
A defining feature of this opportunity was its requirement that proposed projects fall squarely within the scope of the Epi4K CWOW program and rely on the established infrastructure and resources already built by Epi4K. That language signals that applicants were not being asked to reinvent data systems or build a brand-new genomics center from scratch. Instead, the expectation was to integrate with existing consortium processes, which commonly include shared protocols for data generation and quality control, harmonized phenotype definitions, standardized approaches to informed consent and data sharing, and coordinated deposition and exchange of genomic and clinical data. In other words, the program was set up to add new cohorts and analyses into a unified ecosystem so that findings could be compared, replicated, and combined across studies more efficiently.
From an administrative standpoint, the opportunity was offered by the National Institutes of Health under the health-related activity category, with the CFDA listing 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders). The total estimated funding level was listed as $1,000,000, and there was no cost sharing or matching requirement. The FOA was posted on July 13, 2012, and had an original and current closing date of December 18, 2012, with an archive date of January 18, 2013, indicating it was a time-limited solicitation tied to the needs and timeline of the Epi4K program at that point.
Eligibility was broad and included many types of domestic applicants such as state and local governments, public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses and other for-profit organizations, tribal governments and tribal organizations, and various specialized institution categories (for example, HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, and tribally controlled colleges and universities). The announcement also allowed non-U.S. entities to apply, and permitted foreign components as defined by the NIH Grants Policy Statement, which is an important detail for international cohorts or global epilepsy collaborations that may have distinctive patient resources and well-curated sample collections.
Overall, this FOA can be read as a focused call for add-on, high-value epilepsy genomics projects that were ready to execute quickly because the cohorts and DNA were already in hand. The emphasis on next generation sequencing and copy number variant discovery reflects the period when large-scale sequencing was becoming a primary tool for identifying rare and de novo variants in neurologic disease. By requiring use of Epi4K CWOW resources, NIH was aiming to maximize consistency, data quality, and cross-study comparability, while also ensuring that individual projects contributed to a broader, coordinated push to map the genetic architecture of human epilepsies.
Source link for the full announcement was provided as: http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-13-005.html. For access or technical issues, the contact listed was the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: NIH RFA-NS-13-005 (U01) - New Projects for Epi4K Genetics and Genomics of Human Epilepsies Center without Walls
What is RFA-NS-13-005?
RFA-NS-13-005 was an NIH funding opportunity announcement (FOA) titled "New Projects for Epi4K Genetics and Genomics of Human Epilepsies Center without Walls (U01)." It was designed to add new investigators and datasets into the existing Epi4K "Center without Walls" (CWOW) collaborative network to expand epilepsy gene discovery.
What was the main goal of this funding opportunity?
The central goal was to accelerate identification of genetic contributors to human epilepsy by supporting projects that could integrate with Epi4K infrastructure and use modern high-throughput sequencing approaches to discover epilepsy-related genetic variation.
What does it mean that this was a U01 cooperative agreement?
The U01 mechanism is a cooperative agreement, meaning funded teams were expected to work closely with NIH and the Epi4K CWOW consortium. The emphasis was on coordinated project management, shared standards, and integrating results into the broader consortium efforts rather than running a fully independent, R01-style project.
Who was this FOA intended for?
This FOA specifically targeted investigators who already had DNA sample collections from well-characterized cohorts of epilepsy patients, along with strong clinical and phenotypic data suitable for genomics discovery work.
What kinds of patient cohorts were expected?
Applicants were expected to have clearly defined epilepsy syndromes or seizure phenotypes with robust accompanying clinical data, and existing biospecimens appropriate for genomic analysis. The expectation was that cohorts were already assembled and well characterized.
What types of research were expected to be proposed?
The FOA focused on discovery genetics and genomics of human epilepsy, using next generation sequencing (NGS) and associated computational pipelines to discover sequence variants and copy number variants that may contribute to epilepsy risk, epilepsy subtype, or related neurodevelopmental outcomes.
Which technologies and analyses were within scope?
Work was expected to leverage NGS-based strategies such as exome sequencing, genome sequencing, or similar approaches, paired with computational analysis for variant calling, interpretation, and prioritization. Copy number variant discovery was also explicitly part of the scientific focus.
Was the FOA focused on building new infrastructure or using existing consortium resources?
A defining requirement was that proposed projects fall within the scope of the Epi4K CWOW program and rely on infrastructure and resources already established by Epi4K. Projects were expected to integrate into existing consortium processes rather than create a separate, standalone genomics center or independent data system.
What does "Center without Walls" imply for project operations?
In this context, it implies a coordinated collaborative network where multiple teams contribute cohorts and analyses into a shared ecosystem. The FOA emphasized coordinated standards and integration of outputs so findings could be compared, replicated, and combined across studies more efficiently.
What kinds of consortium standards or processes were projects expected to align with?
The FOA described an expectation of integration with consortium processes such as shared protocols for data generation and quality control, harmonized phenotype definitions, standardized approaches to informed consent and data sharing, and coordinated deposition and exchange of genomic and clinical data.
What agency offered this funding opportunity?
This was offered by the National Institutes of Health (NIH) under a health-related activity category.
What CFDA number was associated with this FOA?
The CFDA listing provided was 93.853, titled "Extramural Research Programs in the Neurosciences and Neurological Disorders."
How much total funding was estimated for this opportunity?
The total estimated funding level listed for the FOA was $1,000,000.
Was cost sharing or matching required?
No. The FOA indicated there was no cost sharing or matching requirement.
When was the FOA posted and when did it close?
The FOA was posted on July 13, 2012. The original and current closing date was December 18, 2012. The archive date was January 18, 2013, indicating it was time-limited.
Is this funding opportunity still open?
Based on the dates provided (closing date December 18, 2012 and archive date January 18, 2013), this solicitation was time-limited and is not open.
What types of organizations were eligible to apply?
Eligibility was broad and included state and local governments, public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses and other for-profit organizations, tribal governments and tribal organizations, and additional specialized institution categories.
Were minority-serving institutions and tribally controlled institutions included in the eligible applicant types?
Yes. The eligibility description explicitly included categories such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, and tribally controlled colleges and universities.
Could non-U.S. organizations apply?
Yes. The announcement allowed non-U.S. entities to apply and also permitted foreign components as defined by the NIH Grants Policy Statement.
What is the relevance of allowing foreign components?
This matters for international cohorts or global epilepsy collaborations that may have distinctive patient resources and well-curated sample collections, enabling them to be included under the FOA as described.
What made an application a good fit for this FOA?
Projects were framed as "add-on" high-value epilepsy genomics projects that could execute quickly because cohorts and DNA were already available, and that could plug directly into Epi4K CWOW infrastructure to maximize consistency, data quality, and cross-study comparability.
Where can the full announcement be found?
The source link provided for the full announcement was: http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-13-005.html.
Who was listed as the contact for access or technical issues with the announcement page?
For access or technical issues, the contact listed was the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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