Opportunity Information: Apply for RFA HL 11 025
Apply for RFA HL 11 025
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "New Strategies for Growing 3D Tissues (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Jun 24, 2010 and posted on Jun 24, 2010.
- Applicants must submit their applications by Sep 1, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,875,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) County governments Public and State controlled institutions of higher education For profit organizations other than small businesses Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) State governments Small businesses City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity "New Strategies for Growing 3D Tissues (R01)" (RFA-HL-11-025) is a National Institutes of Health (NIH) Research Project Grant (R01) announcement jointly issued by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB). Its core goal is to push the field of tissue engineering beyond basic 3D culture by improving how researchers understand and control the way cells sense and respond to their surroundings, and by building better assays and experimental methods that can reveal how principles of organogenesis (how organs form during development) can guide the creation of functional, engineered 3D cellular structures. In practice, the FOA is looking for projects that connect fundamental biology to actionable engineering strategies, so that lab-grown tissues can more reliably develop the kinds of behaviors seen in real organisms.
A major emphasis is on multidisciplinary collaboration. The announcement explicitly expects teams that span at least two distinct disciplines, naming areas like developmental biology, computational science and systems biology, cell biology, tissue engineering, chemistry, physics, and organ physiology. Because of that, the multiple principal investigator (multiple PI) approach is strongly encouraged, signaling that the institutes want genuinely integrated, team-based projects rather than single-lab efforts with minor consultative support. The scientific expectation is also fairly demanding: applicants are asked to show reproducible laboratory recapitulation of key cellular and tissue-level events relevant to repair and regeneration, including differentiation, proliferation, and senescence. In other words, the work should not only create 3D cell aggregates but should demonstrate that the system can reliably produce meaningful developmental or regenerative outcomes under controlled conditions.
The opportunity frames long-term impact around tissue repair, replacement, and regeneration, with the idea that progress will come from translating basic biological knowledge into engineered systems that support tissue formation either in vitro (outside the body, such as bioreactors or advanced culture platforms) or in vivo (within the body, such as implanted scaffolds or instructive biomaterials). While the announcement does not prescribe specific technologies, the scope implies interests such as microenvironment design (mechanical, biochemical, and spatial cues), quantitative measurement and validation assays, predictive computational models, and engineered platforms that can guide self-organization or organ-like development in three dimensions.
On the funding side, this is the R01 version of a paired set of announcements: it runs in parallel with a companion FOA of the same scientific scope using the R21 mechanism (RFA-HL-11-026), which typically supports earlier-stage or higher-risk exploratory work. For this R01 FOA, NHLBI planned to commit about $3,875,000 in total costs in fiscal year 2011 to support up to 5 awards, with an estimated total commitment of $16,274,000 across a four-year period. NIBIB planned an additional $500,000 in FY2011 across this FOA and its companion announcement, totaling about $2,000,000 over four years for the combined effort; under that NIBIB arrangement, the institute anticipated supporting up to two R21s or one R01.
Key administrative details include an estimated award ceiling listed as $500,000 (as provided in the source data), no cost sharing or matching requirement, and classification under health-related funding activity categories (including CFDA numbers 93.286, 93.837, 93.838, and 93.839, covering technological innovations for human health and heart, lung, and blood research areas). The opportunity was posted June 24, 2010, with an original and current closing date of September 1, 2010, and an archive date of October 2, 2010.
Eligibility is broad and includes a wide range of domestic organization types: public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other than small businesses), state, county, city/township governments, special district governments, independent school districts, public housing authorities/Indian housing authorities, federally recognized tribal governments, and tribal organizations. The eligibility description also notes additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Overall, the eligibility language signals an intent to attract diverse institutional participants, as long as they can support the kind of multidisciplinary research program the FOA is asking for.
FAQs: New Strategies for Growing 3D Tissues (R01) (RFA-HL-11-025)
What is the name and identifier of this funding opportunity?
The opportunity is titled "New Strategies for Growing 3D Tissues (R01)" and is identified as RFA-HL-11-025.
Which agencies and NIH institutes are issuing this announcement?
This is a National Institutes of Health (NIH) funding opportunity jointly issued by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB).
What grant mechanism does this opportunity use?
This announcement uses the NIH Research Project Grant (R01) mechanism.
What is the core goal of this FOA?
The core goal is to move tissue engineering beyond basic 3D culture by improving how researchers understand and control how cells sense and respond to their surroundings, and by creating better assays and experimental methods to reveal how organogenesis principles can guide the creation of functional, engineered 3D cellular structures.
What kinds of scientific advances is the FOA trying to encourage?
The FOA is seeking projects that connect fundamental biology to actionable engineering strategies so lab-grown tissues can more reliably develop behaviors seen in real organisms. It emphasizes translating biological understanding into engineered systems that support tissue formation and function.
Does the FOA emphasize multidisciplinary collaboration?
Yes. The announcement explicitly expects teams spanning at least two distinct disciplines and highlights a strong emphasis on multidisciplinary collaboration.
Which disciplines are specifically named as relevant?
Examples named include developmental biology, computational science and systems biology, cell biology, tissue engineering, chemistry, physics, and organ physiology.
Is a multiple principal investigator (multiple PI) team structure encouraged?
Yes. The multiple PI approach is strongly encouraged, reflecting an expectation of genuinely integrated, team-based projects.
What level of biological and experimental rigor is expected?
Applicants are asked to demonstrate reproducible laboratory recapitulation of key cellular and tissue-level events relevant to repair and regeneration, including differentiation, proliferation, and senescence. The expectation goes beyond creating 3D aggregates and toward reliably producing meaningful developmental or regenerative outcomes under controlled conditions.
What is the long-term impact or application area described by the FOA?
The long-term impact is framed around tissue repair, replacement, and regeneration, driven by translating basic biological knowledge into engineered systems that support tissue formation.
Is the work expected to be in vitro, in vivo, or both?
The scope includes both in vitro approaches (such as bioreactors or advanced culture platforms) and in vivo approaches (such as implanted scaffolds or instructive biomaterials).
Does the FOA require specific technologies or platforms?
No specific technology is prescribed, but the scope implies interests such as microenvironment design (mechanical, biochemical, and spatial cues), quantitative measurement and validation assays, predictive computational models, and engineered platforms that can guide self-organization or organ-like development in three dimensions.
Is there a companion funding opportunity related to this announcement?
Yes. This R01 FOA runs in parallel with a companion announcement of the same scientific scope using the R21 mechanism: "New Strategies for Growing 3D Tissues (R21)" (RFA-HL-11-026).
How does the companion R21 relate to the R01 in terms of purpose?
The companion R21 is described as typically supporting earlier-stage or higher-risk exploratory work, while this FOA is the R01 version of the paired set.
How much funding did NHLBI plan to commit in FY2011 for this R01 FOA?
NHLBI planned to commit about $3,875,000 in total costs in fiscal year 2011 to support up to 5 awards.
What was the estimated NHLBI total commitment across the four-year period?
The estimated total NHLBI commitment across a four-year period was about $16,274,000.
How much funding did NIBIB plan to commit, as described in the FOA summary?
NIBIB planned an additional $500,000 in FY2011 across this FOA and its companion announcement, totaling about $2,000,000 over four years for the combined effort.
How many awards did NIBIB anticipate supporting under its arrangement?
Under the NIBIB arrangement described, NIBIB anticipated supporting up to two R21s or one R01.
How many total awards were expected under this R01 FOA?
NHLBI planned to support up to 5 awards under this R01 FOA (based on the FY2011 commitment described).
Is there an award ceiling listed?
Yes. The source data lists an estimated award ceiling of $500,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What are the CFDA numbers associated with this opportunity?
The announcement lists CFDA numbers 93.286, 93.837, 93.838, and 93.839, covering health-related research areas including technological innovations for human health and heart, lung, and blood research.
When was this opportunity posted?
The opportunity was posted on June 24, 2010.
What was the closing date for applications?
The original and current closing date listed is September 1, 2010.
When was the opportunity archived?
The archive date is October 2, 2010.
Who is eligible to apply?
Eligibility is broad and includes many domestic organization types, such as public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status); for-profit organizations (including small businesses and other than small businesses); state, county, and city/township governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; federally recognized tribal governments; and tribal organizations.
Are specific institution categories (such as minority-serving institutions) mentioned as eligible?
Yes. The eligibility description notes additional eligible applicants including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are federal agencies and community-based organizations included in the eligibility language?
Yes. The eligibility description includes eligible federal agencies as well as faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
What overall type of applicant does the eligibility language seem designed to attract?
The language signals an intent to attract diverse institutional participants, as long as they can support the multidisciplinary research program described in the FOA.
Browse more opportunities from the same category: Health
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Previous opportunity: Notice of Intent to Award Sole Source Backlog Cataloging
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