Opportunity Information: Apply for RFA HL 16 004
Apply for RFA HL 16 004
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "NHLBI Bench to Bassinet Program Administrative Coordinating Center (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Nov 4, 2014 and posted on Nov 4, 2014.
- Applicants must submit their applications by Mar 17, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $6,505,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $6,230,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Small businesses Public and State controlled institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The NHLBI Bench to Bassinet Program Administrative Coordinating Center (U01) funding opportunity (RFA HL 16 004) is a cooperative agreement intended to support a single organization to serve as the central Administrative Coordinating Center (ACC) for two NHLBI-supported research consortia: the Cardiovascular Development Consortium (RFA HL 15 013) and the Pediatric Cardiac Genomics Consortium (RFA HL 15 012). Together, these groups form the Bench to Bassinet Program (B2B), an NHLBI translational research initiative focused on pediatric cardiovascular disease, with a major emphasis on understanding the causes of congenital heart disease and improving outcomes for affected individuals. The ACC is essentially the operational hub that helps these multi-site, multi-disciplinary consortia function as an integrated program rather than a collection of separate projects.
The underlying goal of B2B is to reduce the classic bottlenecks that slow translational science, especially the gap between basic discoveries and real-world clinical advances. Launched in 2009, the program is designed to push discoveries along the pipeline from fundamental developmental biology and genomics through translational validation and toward clinical research questions that matter directly to patients and clinicians. A defining feature of this opportunity is the expectation of active collaboration across scientific domains: basic scientists, translational researchers, and clinical investigators are meant to work in a coordinated way so that laboratory findings can be shaped by clinical needs, and clinical research can be informed by emerging mechanistic and genomic insights.
A key aspect of the ACC role is supporting coordination and communication not only within each consortium but also between the two consortia and with the NHLBI Pediatric Heart Network (PHN). The FOA highlights that these interactions are intended to strengthen bidirectional translation: moving results from basic science toward clinical studies, while also ensuring clinicians can provide input on the most pressing gaps that basic research should address. In practical terms, this means the ACC is expected to enable cross-consortium alignment, facilitate joint planning and problem-solving, and help maintain a common direction across different research teams and institutions.
From an administrative and program-management perspective, the ACC mechanism signals that NHLBI intends substantial involvement in the program through the cooperative agreement structure. Unlike a standard grant where investigators operate with comparatively more independence, a U01 cooperative agreement typically involves a closer partnership with NIH staff and program officials, with coordination, milestones, and collaborative governance being central to success. This is consistent with what B2B is trying to accomplish: building a coordinated translational ecosystem rather than funding isolated projects.
The FOA anticipated one award, with an estimated total funding level of about $6.505 million and an award ceiling listed as $6.23 million. There is no cost sharing or matching requirement. The opportunity was posted on November 4, 2014, and had an application closing date of March 17, 2015, with an archive date of April 17, 2015. The activity falls under health-related categories and is associated with CFDA numbers 93.837 (Cardiovascular Diseases Research) and 93.865 (Child Health and Human Development Extramural Research).
Eligibility is broad and includes many types of U.S.-based organizations and governmental entities, such as higher education institutions (public and private), nonprofits (including 501(c)(3) organizations), for-profit organizations (including small businesses and other for-profits), and various levels of government (state, county, city/township), as well as tribal governments and certain special district governments. The FOA also explicitly lists eligibility for a range of mission-focused institutions, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions, among others. At the same time, non-U.S. entities are not eligible to apply, and foreign components are not allowed, consistent with NIH policy limitations stated in the announcement.
Overall, this grant opportunity is best understood as funding the backbone infrastructure for the Bench to Bassinet translational program: the administrative center that keeps complex, collaborative pediatric cardiovascular research networks aligned, communicating effectively, and positioned to move discoveries from developmental biology and genomics toward clinically meaningful advances in congenital heart disease.
FAQs: NHLBI Bench to Bassinet Program Administrative Coordinating Center (U01) - RFA HL 16 004
What is this funding opportunity?
This opportunity (RFA HL 16 004) is an NHLBI cooperative agreement (U01) to support a single organization to serve as the Bench to Bassinet Program (B2B) Administrative Coordinating Center (ACC). The ACC functions as the central coordinating hub for the overall program.
What is the Bench to Bassinet Program (B2B)?
B2B is an NHLBI translational research initiative focused on pediatric cardiovascular disease, with a major emphasis on understanding the causes of congenital heart disease and improving outcomes for individuals affected by congenital heart disease. The program was launched in 2009 and is designed to move discoveries from basic developmental biology and genomics toward translational validation and clinically meaningful research questions.
What does the Administrative Coordinating Center (ACC) do?
The ACC is intended to be the operational backbone of B2B. Its role is to support administration, coordination, and communication so the participating multi-site, multi-disciplinary consortia operate as an integrated program rather than as separate, disconnected projects.
Which research groups does the ACC support?
The ACC supports two NHLBI-supported research consortia: the Cardiovascular Development Consortium (RFA HL 15 013) and the Pediatric Cardiac Genomics Consortium (RFA HL 15 012). Together, these two consortia form the Bench to Bassinet Program (B2B).
Is the ACC expected to coordinate work between the two consortia?
Yes. A central expectation described in the opportunity is that the ACC enables coordination and communication not only within each consortium, but also between the two consortia so they can align activities, plan jointly when needed, and maintain a shared direction across institutions and teams.
How does the NHLBI Pediatric Heart Network (PHN) fit into this opportunity?
The ACC is expected to support coordination and communication between the two B2B consortia and the NHLBI Pediatric Heart Network (PHN). These interactions are intended to strengthen bidirectional translation between basic/translational research and clinical needs.
What is meant by "bidirectional translation" in this program?
In this context, bidirectional translation means two things happening at the same time: (1) moving results from basic science toward translational and clinical studies, and (2) ensuring clinicians can provide input on the most urgent gaps and questions that basic research should address.
Why is this a cooperative agreement (U01) instead of a standard grant?
The U01 mechanism signals substantial NHLBI involvement in the program. Compared with a more independent standard grant, a cooperative agreement typically involves closer partnership with NIH staff and program officials, and emphasizes coordination, milestones, and collaborative governance as core parts of success.
How many awards were anticipated?
The funding opportunity anticipated one award to support a single organization serving as the ACC.
What was the estimated funding level and award ceiling?
The FOA listed an estimated total funding level of about $6.505 million and an award ceiling of $6.23 million.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
When was the opportunity posted and when were applications due?
The opportunity was posted on November 4, 2014. The application closing date was March 17, 2015.
What is the archive date listed for this opportunity?
The archive date listed in the opportunity is April 17, 2015.
What types of organizations were eligible to apply?
Eligibility was broad for U.S.-based entities and included higher education institutions (public and private), nonprofits (including 501(c)(3) organizations), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township), as well as tribal governments and certain special district governments.
Were minority-serving and mission-focused institutions included as eligible applicants?
Yes. The opportunity explicitly included eligibility for a range of mission-focused institutions, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions, among others.
Are non-U.S. organizations eligible to apply?
No. Non-U.S. entities were not eligible to apply.
Are foreign components allowed?
No. Foreign components were not allowed, consistent with NIH policy limitations stated in the announcement.
What health topics and research areas does this opportunity fall under?
The activity falls under health-related categories and is centered on pediatric cardiovascular disease, particularly congenital heart disease, spanning developmental biology, genomics, translational validation, and clinical research alignment.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA 93.837 (Cardiovascular Diseases Research) and CFDA 93.865 (Child Health and Human Development Extramural Research).
What problem is B2B trying to solve, and how does the ACC help?
B2B is intended to reduce common bottlenecks that slow translational science, especially the gap between basic discoveries and real-world clinical advances. The ACC contributes by keeping complex collaborations aligned and communicating effectively, facilitating joint planning and problem-solving, and supporting a coordinated translational ecosystem rather than isolated efforts.
What is the overall purpose of funding an ACC instead of additional individual research projects?
This opportunity is best understood as funding the backbone infrastructure that enables the Bench to Bassinet Program to function as a unified, collaborative program. The ACC is meant to keep the networks organized and connected so discoveries can more effectively move from developmental biology and genomics toward clinically meaningful advances in congenital heart disease.
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