Opportunity Information: Apply for RFA HL 09 002
Apply for RFA HL 09 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NHLBI Cardiac Development Consortium (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research.
- This funding opportunity was created on Dec 4, 2008 and posted on Dec 4, 2008.
- Applicants must submit their applications by Feb 6, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The NHLBI Cardiac Development Consortium (U01) (Funding Opportunity Number RFA HL 09 002) is a National Institutes of Health grant opportunity led by the National Heart, Lung, and Blood Institute (NHLBI) in partnership with the Canadian Institutes of Health Research (CIHR). Its central aim is to build a coordinated, multi-site research consortium focused on cardiovascular development, specifically by supporting basic, collaborative science that can produce a deeper, more integrated understanding of the regulatory networks that control how the heart and cardiovascular system form and mature. Rather than funding isolated projects, the program is designed to connect multiple teams into a single cooperative effort where data, methods, and outputs are aligned and shared quickly to accelerate progress for the broader field.
The planned consortium structure includes up to four Research Centers, optional shared scientific Cores (as needed to support specialized technologies or resources), and a Steering Committee to guide overall direction, coordination, and collaborative decision-making. Research Center applicants are expected to propose projects that concentrate on key regulatory pathways involved in cardiovascular development, map out pathway components and downstream targets, and emphasize rapid dissemination of data to the scientific community. A major expectation is that the different centers will work together to maximize interoperability, meaning the datasets, formats, standards, and potentially tools produced across sites should be compatible enough to be integrated, compared, and reused across the consortium and by outside investigators.
This initiative sits within a broader NHLBI translational program in pediatric cardiovascular disease. It is explicitly linked to companion efforts, including the NHLBI Pediatric Cardiac Genomics Consortium and an Administrative Coordinating Center. These related groups are expected to interact with the Cardiac Development Consortium and with the NHLBI Pediatric Heart Network to strengthen the pipeline from basic developmental biology to clinically relevant insights and future clinical research. In practical terms, the program is designed so that clinical priorities and unmet needs can help shape basic research questions, and discoveries about developmental regulatory networks can more readily inform pediatric cardiovascular understanding and, eventually, interventions.
Funding is provided through the U01 Research Project Cooperative Agreement mechanism, which typically indicates substantial scientific and programmatic involvement by NIH staff compared with standard investigator-initiated grants. Financially, NHLBI indicated an intent to commit approximately $960,000 in total costs in FY2009, with a maximum total of $32,960,000 in total costs across the full six-year project period for the consortium as a whole. The anticipated number of awards is up to four Research Centers.
Eligibility is broad and includes many common applicant types across academia, nonprofit, government, and certain private-sector organizations. Eligible applicants listed include public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status, excluding institutions of higher education), state governments, small businesses, and for-profit organizations other than small businesses. Additional eligible categories include various mission-serving and minority-serving institutions (such as HBCUs, Hispanic-serving institutions, Tribal Colleges and Universities, and Alaska Native and Native Hawaiian Serving Institutions), eligible federal agencies, and non-U.S. entities (foreign organizations). The opportunity does not require cost sharing or matching. Key dates show it was posted on December 4, 2008, with an original and current closing date of February 6, 2009, and an archive date of March 9, 2009. The program is cataloged under CFDA 93.837 (Cardiovascular Diseases Research).
Frequently Asked Questions (FAQs)
What is the NHLBI Cardiac Development Consortium (U01) funding opportunity?
It is a National Institutes of Health (NIH) grant opportunity led by the National Heart, Lung, and Blood Institute (NHLBI), in partnership with the Canadian Institutes of Health Research (CIHR), to create a coordinated, multi-site research consortium focused on cardiovascular development.
What is the Funding Opportunity Number (FON) and title?
The opportunity is titled the NHLBI Cardiac Development Consortium (U01) and uses Funding Opportunity Number RFA HL 09 002.
What is the central goal of the program?
The central goal is to support basic, collaborative science that produces a deeper, more integrated understanding of the regulatory networks that control how the heart and cardiovascular system form and mature.
Is this program intended to fund standalone, isolated research projects?
No. The program is designed to connect multiple teams into a single cooperative effort where data, methods, and outputs are aligned and shared quickly to accelerate progress for the broader field.
What kind of science does the program emphasize?
It emphasizes basic research in cardiovascular development, with an expectation that projects will focus on key regulatory pathways, identify pathway components and downstream targets, and contribute to an integrated understanding of developmental regulatory networks.
What is the expected structure of the consortium?
The planned structure includes up to four Research Centers, optional shared scientific Cores (as needed to support specialized technologies or resources), and a Steering Committee to guide direction, coordination, and collaborative decision-making.
How many awards are anticipated?
Up to four Research Center awards are anticipated.
What are shared scientific Cores, and are they required?
Cores are optional shared resources that may be used to support specialized technologies or consortium-wide resources. They are described as optional and used as needed.
What is the purpose of the Steering Committee?
The Steering Committee is intended to guide overall direction, coordination, and collaborative decision-making for the consortium.
What is expected of Research Center applicants?
Research Center applicants are expected to propose projects that (1) concentrate on key regulatory pathways involved in cardiovascular development, (2) map pathway components and downstream targets, and (3) emphasize rapid dissemination of data to the scientific community.
What does “rapid dissemination of data” mean in the context of this opportunity?
Based on the description, it means research centers should prioritize getting data out to the broader scientific community quickly, consistent with a consortium model that aligns outputs and shares them efficiently to accelerate the field.
What does “interoperability” mean for participating centers?
Interoperability means the datasets, formats, standards, and potentially the tools produced across different sites should be compatible enough to be integrated, compared, and reused across the consortium and by outside investigators.
How is this initiative connected to pediatric cardiovascular disease research?
This initiative is positioned within a broader NHLBI translational program in pediatric cardiovascular disease, aiming to strengthen the pipeline from basic developmental biology to clinically relevant insights and future clinical research.
Are there companion programs or related efforts tied to this consortium?
Yes. It is explicitly linked to companion efforts including the NHLBI Pediatric Cardiac Genomics Consortium and an Administrative Coordinating Center, and it is expected to interact with the NHLBI Pediatric Heart Network.
How are clinical priorities expected to influence the research?
The program is designed so that clinical priorities and unmet needs can help shape basic research questions, and so discoveries about developmental regulatory networks can more readily inform pediatric cardiovascular understanding and, eventually, interventions.
What funding mechanism is used for this opportunity?
The program uses the U01 Research Project Cooperative Agreement mechanism.
What does a U01 cooperative agreement imply compared with a standard grant?
A U01 cooperative agreement typically indicates substantial scientific and programmatic involvement by NIH staff compared with standard investigator-initiated grants.
What is the planned funding level for the consortium?
NHLBI indicated an intent to commit approximately $960,000 in total costs in FY2009, with a maximum total of $32,960,000 in total costs across the full six-year project period for the consortium as a whole.
What is the project period mentioned for the consortium?
The description references a full six-year project period for the consortium as a whole.
Does the opportunity require cost sharing or matching funds?
No. The opportunity states that cost sharing or matching is not required.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status, excluding institutions of higher education); state governments; small businesses; and for-profit organizations other than small businesses.
Are minority-serving institutions included in the eligible applicant types?
Yes. The eligible categories include mission-serving and minority-serving institutions such as HBCUs, Hispanic-serving institutions, Tribal Colleges and Universities, and Alaska Native and Native Hawaiian Serving Institutions.
Are federal agencies eligible to apply?
Yes. Eligible applicants include eligible federal agencies.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligible applicants include non-U.S. entities (foreign organizations).
When was this funding opportunity posted?
It was posted on December 4, 2008.
What was the application closing date?
The original and current closing date listed is February 6, 2009.
When was the opportunity archived?
The archive date listed is March 9, 2009.
What is the CFDA number associated with this program?
The program is cataloged under CFDA 93.837 (Cardiovascular Diseases Research).
What is the intended benefit of organizing the work as a consortium?
The intent is to accelerate progress by aligning multiple teams, coordinating approaches, enabling fast sharing of data and methods, and producing outputs that can be integrated and reused across sites and by the broader research community.
How does this consortium relate to data standards and shared outputs?
A major expectation is that the centers coordinate to maximize interoperability, meaning shared or compatible datasets, formats, standards, and possibly tools that support integration and reuse.
What research theme should applicants center their proposals around?
Applicants are expected to center proposals on cardiovascular development, with a particular focus on key regulatory pathways and the broader regulatory networks controlling heart and cardiovascular system formation and maturation.
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