Opportunity Information: Apply for PAR 12 137
Apply for PAR 12 137
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NHLBI Career Transition Award (K22)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Jul 30, 2014 and posted on Mar 23, 2012.
- Applicants must submit their applications by Jul 30, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Public and State controlled institutions of higher education Independent school districts Native American tribal governments (Federally recognized) County governments Public housing authorities/Indian housing authorities Special district governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in theNIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The NHLBI Career Transition Award (K22) is a National Institutes of Health (NIH) grant opportunity from the National Heart, Lung, and Blood Institute (NHLBI) designed to help exceptionally promising postdoctoral researchers move from advanced mentored training into independent faculty-level research careers. The program is built specifically to bridge the common gap between postdoctoral work and launching a self-directed research program, by pairing an initial period of structured, mentored research inside NHLBI's own intramural research environment with a later period of independent support after the awardee secures a position at an extramural institution (such as a university, medical center, or research institute). In practical terms, it is meant to take someone who is ready for independence but still benefits from intensive mentorship and give them a clear, well-supported runway into becoming a new investigator with their own research direction.
The award is organized into two sequential phases totaling up to five years of combined support. Phase 1 is a mentored intramural phase lasting up to two years and is conducted within the NHLBI Division of Intramural Research. During this period, the awardee works under mentorship while building a strong scientific track record and preparing for independence, often including developing publications, establishing a coherent research niche, and shaping a future independent research plan. Phase 2 is an extramural phase lasting up to three years, intended to provide funding once the awardee transitions to an eligible extramural institution where they will operate as an independent or transitioning-to-independent investigator. Together, these phases are structured to move the investigator from intensive mentorship to independence while maintaining continuity of support so that the research program does not stall during the career move.
A key feature of this K22 is that the transition from the intramural phase to the extramural phase is not automatic. The shift into the three-year extramural funding period requires NHLBI approval, and that approval depends on an NHLBI progress review assessing how well the awardee has advanced during the intramural phase. As described in the announcement, the review includes an evaluation of the awardee's research progress and a research plan specifically proposed for implementation at the extramural institution. This requirement is important because it means awardees must treat the intramural phase as a performance-based launch period, demonstrating clear productivity, scientific growth, and readiness to execute an independent program. The extramural plan is not just a formality; it is part of the evidence that the investigator is prepared to lead a research program in a new setting.
In terms of scientific scope, the opportunity falls under NIH health research activities and aligns with NHLBI mission areas. The CFDA (assistance listing) numbers associated with the announcement indicate coverage across major NHLBI domains, including cardiovascular diseases research (93.837), lung diseases research (93.838), blood diseases and resources research (93.839), and sleep disorders research through the National Center on Sleep Disorders Research (93.233). In other words, the mechanism is intended for research trajectories relevant to heart, lung, blood, and sleep-related science, which can range from basic mechanistic work to translational and clinically relevant investigations, as long as it fits NHLBI priorities and is suitable for a mentored-to-independent career transition structure.
Eligibility is described primarily in institutional terms for the extramural phase and reflects the broad set of U.S.-based organizations that can typically receive NIH grant funding. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and a range of government entities (state, county, city or township, special district governments, independent school districts, and certain housing authorities). Tribal governments and tribal organizations are included, along with a number of designated institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations. Regional organizations and eligible federal agencies are also mentioned. At the same time, the opportunity is clear that non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components are not allowed, consistent with NIH policy language in the announcement.
Administrative details from the posting show that this was a discretionary grant funding opportunity (Funding Instrument: Grant) released under Funding Opportunity Number PAR-12-137, with a posted date of March 23, 2012. The record includes multiple dates reflecting the lifecycle of the announcement (including an original closing date of September 6, 2015, and an archive date of August 30, 2014, as captured in the provided source data). There is no cost sharing or matching requirement listed, meaning applicants are not required to provide matching funds as a condition of the award, which is typical for many NIH career development and transition mechanisms. The full funding announcement was made available through the NIH Grants Guide (link provided in the source), and NIH Office of Extramural Research (OER) webmaster contacts were supplied for technical access issues.
Overall, the NHLBI K22 Career Transition Award is best understood as a structured, milestone-dependent pathway: it first places a highly qualified postdoctoral fellow into a mentored intramural environment at NHLBI for up to two years, then, contingent on strong progress and an approved independent research plan, provides up to three additional years of support to help the investigator establish and grow a research program at an eligible U.S. extramural institution. The intent is not just to fund a project, but to develop a researcher into an independent investigator with the publications, preliminary data, and strategic research direction needed to compete long-term for extramural NIH funding.
FAQs: NHLBI Career Transition Award (K22) - PAR-12-137
What is the NHLBI Career Transition Award (K22)?
The NHLBI Career Transition Award (K22) is a National Institutes of Health (NIH) grant opportunity from the National Heart, Lung, and Blood Institute (NHLBI) designed to help exceptionally promising postdoctoral researchers move from advanced mentored training into independent, faculty-level research careers.
What is the main goal of this K22 program?
The program is meant to bridge the common gap between postdoctoral work and launching a self-directed research program. It does this by combining (1) a structured, mentored research period inside NHLBI's intramural research environment and (2) a later period of independent support after the awardee secures a position at an extramural institution.
How is the award structured?
The award has two sequential phases totaling up to five years of combined support: a mentored intramural phase (up to two years) followed by an extramural phase (up to three years) after transition to an eligible U.S. extramural institution.
How long is Phase 1 (the intramural mentored phase)?
Phase 1 lasts up to two years and is conducted within the NHLBI Division of Intramural Research.
What happens during the intramural mentored phase?
During Phase 1, the awardee works in NHLBI's intramural program under mentorship while building a strong scientific track record and preparing for independence. The description highlights activities such as developing publications, establishing a coherent research niche, and shaping a future independent research plan.
How long is Phase 2 (the extramural phase)?
Phase 2 lasts up to three years and provides funding after the awardee transitions to an eligible extramural institution (for example, a university, medical center, or research institute).
Is the transition from Phase 1 to Phase 2 automatic?
No. The transition from the intramural phase to the extramural phase is not automatic. Moving into the three-year extramural funding period requires NHLBI approval.
What is required to obtain NHLBI approval to transition to the extramural phase?
NHLBI approval depends on an NHLBI progress review. The review evaluates the awardee's research progress during the intramural phase and also evaluates a research plan specifically proposed for implementation at the extramural institution.
Why is the progress review important?
The review makes Phase 1 a performance-based launch period. Awardees are expected to demonstrate clear productivity, scientific growth, and readiness to execute an independent research program, and to present a credible extramural research plan as part of the evidence of readiness.
What scientific areas does this K22 support?
The opportunity aligns with NHLBI mission areas under NIH health research activities and is associated with major NHLBI scientific domains, including cardiovascular diseases research, lung diseases research, blood diseases and resources research, and sleep disorders research.
Which assistance listing (CFDA) areas are referenced for this opportunity?
The announcement references assistance listing (CFDA) numbers that indicate coverage across NHLBI domains: cardiovascular diseases research (93.837), lung diseases research (93.838), blood diseases and resources research (93.839), and sleep disorders research through the National Center on Sleep Disorders Research (93.233).
Does the K22 focus only on basic research, or can it include translational/clinical work?
Based on the description, supported research trajectories can range from basic mechanistic work to translational and clinically relevant investigations, as long as the work fits NHLBI priorities and is suitable for a mentored-to-independent career transition structure.
Where is the intramural phase conducted?
The intramural phase is conducted within the NHLBI Division of Intramural Research.
What kinds of institutions can host the extramural phase?
The extramural phase can take place at an eligible U.S. extramural institution, such as a university, medical center, or research institute, provided it falls within the eligible applicant organization types described in the announcement.
What types of organizations are eligible to apply as the extramural institution?
Eligible applicants include a broad range of U.S.-based organizations typically eligible for NIH funding, including public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses), and multiple government entities (state, county, city or township, special district governments, independent school districts, and certain housing authorities).
Are Tribal governments and Tribal organizations eligible?
Yes. Tribal governments and Tribal organizations are included among eligible applicants.
Are specific institution designations mentioned as eligible?
Yes. The opportunity listing includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations. Regional organizations and eligible federal agencies are also mentioned.
Are non-U.S. entities eligible to apply?
No. The opportunity states that non-U.S. entities are not eligible to apply.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed under this opportunity?
No. The opportunity indicates that foreign components are not allowed, consistent with the NIH policy language referenced in the announcement.
What is the funding instrument for this opportunity?
The funding instrument is a discretionary grant (Funding Instrument: Grant).
What is the funding opportunity number (FON) for this announcement?
The funding opportunity number is PAR-12-137.
When was this opportunity posted?
The posted date listed is March 23, 2012.
Does the listing include closing and archive dates?
Yes. The record includes multiple lifecycle dates, including an original closing date of September 6, 2015, and an archive date of August 30, 2014, as captured in the provided source data.
Is cost sharing or matching required?
No. The posting indicates there is no cost sharing or matching requirement, meaning applicants are not required to provide matching funds as a condition of the award.
Where can applicants find the full funding announcement?
The full funding announcement is available through the NIH Grants Guide (a link was provided in the source information).
Who is listed for technical or access-related help?
NIH Office of Extramural Research (OER) webmaster contacts are provided in the posting for technical access issues.
What is the program trying to prevent during the career move?
The two-phase structure is intended to maintain continuity of support so the research program does not stall while the investigator moves from postdoctoral training into an independent position at an extramural institution.
What does the K22 support beyond a specific research project?
The opportunity is framed as a career development and transition pathway. Its intent is to develop a researcher into an independent investigator with the publications, preliminary data, and strategic research direction needed to compete long-term for extramural NIH funding.
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