Opportunity Information: Apply for PAR 12 138
Apply for PAR 12 138
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NHLBI Systems Biology Collaborations (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Mar 23, 2012 and posted on Mar 23, 2012.
- Applicants must submit their applications by Jan 13, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Independent school districts State governments Special district governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NHLBI Systems Biology Collaborations (R01) funding opportunity (PAR-12-138) was a National Institutes of Health discretionary grant program run by the National Heart, Lung, and Blood Institute (NHLBI). It invited Research Project Grant (R01) applications that bring together truly collaborative, multidisciplinary teams to conduct systems biology research aimed at improving understanding of normal physiology and the biological disruptions that lead to, or occur in, heart, lung, blood, and sleep (HLBS) diseases and disorders. The central idea was to support projects that do more than run parallel experimental and computational work; the FOA emphasized integrated, team-based research where experimental studies and computational/modeling approaches inform each other in a coordinated plan to generate a systems-level view of complex biology.
A defining feature of the opportunity was the requirement for multidisciplinary expertise spanning both experimental and computational domains. Applicants were expected to assemble teams capable of producing and analyzing rich biological data (for example, from cellular, molecular, tissue, organismal, or clinical sources) and combining those data with computational strategies such as mathematical modeling, network analysis, multiscale simulations, or other integrative analytical approaches. The FOA explicitly allowed the multi-PI mechanism, reflecting NHLBI's expectation that projects would be led by investigators with complementary skill sets who share responsibility for the science. That structure was meant to encourage genuine integration across disciplines rather than a traditional single-lab model with limited cross-domain coordination.
The scope aligned with NHLBI's mission areas and related NIH assistance listings: 93.837 (Cardiovascular Diseases Research), 93.838 (Lung Diseases Research), and 93.839 (Blood Diseases and Resources Research). While the announcement text highlights heart, lung, blood, and sleep disorders broadly, the emphasis was on using systems biology methods to explain both normal function and disease-associated perturbations, meaning projects could plausibly range from mechanistic and pathway-level studies to multiscale models linking molecules to organs or clinical phenotypes, as long as the work was cohesive and systems-focused.
In terms of eligibility, the FOA was broadly open to many organization types. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (other than small businesses, while small businesses were also eligible), and numerous government entities such as state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility language also explicitly included a variety of mission-focused or identity-serving institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, as well as regional organizations, U.S. territories or possessions, and eligible federal agencies. Importantly, non-U.S. entities (foreign institutions) were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components were allowed as defined by NIH policy, signaling that international collaboration was permissible when it strengthened the science.
The opportunity did not require cost sharing or matching, consistent with typical NIH R01 mechanisms. Key administrative dates show it was posted and created on March 23, 2012, with a closing date of January 13, 2015, and it was archived on February 13, 2015. Additional details and the full official announcement were provided through the NIH Grants Guide page linked in the notice. For access or linking problems, NIH directed applicants to the NIH Office of Extramural Research (OER) webmaster contact listed in the announcement.
Overall, PAR-12-138 was designed to push HLBS research toward integrated, systems-level explanations by funding collaborative R01 projects that tightly combine experimental biology and computational modeling, using team science and (when appropriate) multiple principal investigators to ensure cross-disciplinary integration is central to the research plan rather than an add-on.
Frequently Asked Questions (FAQs): NHLBI Systems Biology Collaborations (R01) - PAR-12-138
What is PAR-12-138?
PAR-12-138, titled NHLBI Systems Biology Collaborations (R01), was a National Institutes of Health (NIH) discretionary grant funding opportunity run by the National Heart, Lung, and Blood Institute (NHLBI). It invited Research Project Grant (R01) applications to support collaborative systems biology research relevant to heart, lung, blood, and sleep (HLBS) biology and disease.
What was the main purpose of this funding opportunity?
The purpose was to fund truly collaborative, multidisciplinary R01 projects that use systems biology approaches to improve understanding of normal physiology and the biological disruptions that lead to, or occur in, HLBS diseases and disorders. The focus was on generating a systems-level view of complex biology through coordinated experimental and computational work.
What type of grant mechanism did PAR-12-138 use?
This opportunity used the NIH R01 (Research Project Grant) mechanism.
What made this FOA different from projects that run experiments and modeling in parallel?
A defining feature was the emphasis on integration. The FOA supported projects that go beyond separate experimental and computational activities conducted side-by-side. Instead, it emphasized a coordinated plan where experimental studies and computational/modeling approaches inform each other to produce an integrated systems biology outcome.
What scientific areas were in scope?
The scope aligned with NHLBI mission areas and broadly covered heart, lung, blood, and sleep (HLBS) biology and related diseases or disorders. The emphasis was on systems biology methods to explain both normal function and disease-associated perturbations.
Which NIH assistance listings were associated with this opportunity?
The opportunity aligned with the following NIH assistance listings:
- 93.837 - Cardiovascular Diseases Research
- 93.838 - Lung Diseases Research
- 93.839 - Blood Diseases and Resources Research
What kinds of research approaches did the FOA expect?
Applicants were expected to combine rich biological data with computational strategies to create integrative systems-level insight. Examples of approaches named in the opportunity included:
- Generating and analyzing biological data from cellular, molecular, tissue, organismal, or clinical sources
- Applying computational strategies such as mathematical modeling, network analysis, multiscale simulations, or other integrative analytical approaches
Was multidisciplinary expertise required?
Yes. A defining feature was the requirement for multidisciplinary expertise spanning both experimental and computational domains. Teams were expected to be able to produce biological data and analyze/integrate it using computational and modeling methods.
Did the FOA allow multiple principal investigators (multi-PI)?
Yes. The FOA explicitly allowed the multi-PI mechanism, reflecting NHLBI expectations that projects would be led by investigators with complementary skill sets who share responsibility for the science.
Why did NHLBI emphasize the multi-PI option for this opportunity?
The multi-PI structure was meant to encourage genuine integration across disciplines rather than a traditional single-lab model with limited cross-domain coordination. It supported the team-science intent of the program.
What types of organizations were eligible to apply?
Eligibility was broad and included many organization types, including:
- Public and private institutions of higher education
- Nonprofit organizations (including 501(c)(3) and non-501(c)(3))
- For-profit organizations (including small businesses, and other for-profits as described in the opportunity)
- Government entities such as state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities
- Other eligible entities described in the opportunity, including regional organizations, U.S. territories or possessions, and eligible federal agencies
Were mission-focused or identity-serving institutions explicitly included as eligible?
Yes. The eligibility language explicitly included a variety of institutions and organizations such as:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Faith-based or community-based organizations
Could non-U.S. (foreign) organizations apply?
Yes. The opportunity stated that non-U.S. entities (foreign institutions) were eligible to apply. It also allowed non-U.S. components of U.S. organizations and permitted foreign components as defined by NIH policy, indicating international participation was permissible when it strengthened the science.
Was cost sharing or matching required?
No. The opportunity did not require cost sharing or matching, consistent with typical NIH R01 mechanisms.
What were the key dates for this funding opportunity?
The notice listed these administrative dates:
- Posted/Created: March 23, 2012
- Closing Date: January 13, 2015
- Archived: February 13, 2015
Is this funding opportunity still active?
No. Based on the provided dates, the FOA closed on January 13, 2015 and was archived on February 13, 2015.
Where were applicants directed to find the full official announcement?
Additional details and the full official announcement were provided through the NIH Grants Guide page linked in the notice.
What should an applicant do if they had access or linking problems to the official announcement?
NIH directed applicants with access or linking problems to contact the NIH Office of Extramural Research (OER) webmaster listed in the announcement.
What overall research direction was NHLBI trying to encourage with PAR-12-138?
The opportunity was designed to push HLBS research toward integrated, systems-level explanations by funding collaborative R01 projects that tightly combine experimental biology and computational modeling, using team science and (when appropriate) multiple principal investigators so integration is central to the research plan rather than an add-on.
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