Opportunity Information: Apply for RFA AI 14 016
Apply for RFA AI 14 016
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIAID Division of Allergy, Immunology and Transplantation Statistical and Clinical Coordinating Center (UM2)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Mar 26, 2014 and posted on Mar 26, 2014.
- Applicants must submit their applications by Jul 18, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $16,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $16,500,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public housing authorities/Indian housing authorities For profit organizations other than small businesses City or township governments Public and State controlled institutions of higher education State governments County governments Private institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The NIAID Division of Allergy, Immunology and Transplantation Statistical and Clinical Coordinating Center (UM2) funding opportunity (RFA-AI-14-016) is a National Institutes of Health cooperative agreement designed to support a single, centralized coordinating center that can run the operational and analytic backbone for multiple NIAID-supported clinical research efforts. The main idea is that DAIT funds and oversees a wide portfolio of studies in asthma and allergic diseases, autoimmune diseases, and transplantation, and this award creates one dedicated hub to help those programs design studies well, launch them efficiently, keep them compliant and safe while they are running, and produce rigorous final analyses at the end.
Because this is a cooperative agreement, the relationship is meant to be collaborative rather than hands-off. The awardee is expected to work closely with NIAID program leadership and the various DAIT-supported research networks and study teams. In practice, that usually means shared planning, frequent coordination calls, and ongoing involvement by NIH staff in major scientific and operational decisions, especially around protocol design, safety oversight, and data and analysis standards.
The center is expected to provide end-to-end support across the full lifecycle of clinical research. On the front end, that includes statistical leadership for study design (such as selecting endpoints, calculating sample sizes, developing randomization schemes, and planning interim monitoring), as well as helping investigators turn scientific aims into executable protocols and analysis plans. During start-up and conduct of studies, the center is responsible for core operational functions like study initiation, project management, and the practical coordination needed to keep multi-site work moving on schedule. A major piece of the role is building and maintaining robust data management systems, including the collection, cleaning, validation, and secure handling of study data, along with the documentation and standards that make data usable across multiple studies and disease areas. The center also supports monitoring activities at clinical sites, which typically includes ensuring adherence to protocols, data quality checks, and helping sites resolve issues quickly and consistently.
Safety oversight is an explicit part of the scope. The coordinating center is expected to provide safety monitoring support, which generally involves adverse event collection and reporting workflows, preparation of safety summaries for oversight bodies, and helping maintain the infrastructure needed for appropriate clinical trial oversight. At the end of each study, the center is responsible for the final statistical analysis and for supporting the interpretation and reporting of findings, so that results are defensible, transparent, and aligned with the pre-specified analysis approach. The opportunity is broad in the types of research it is meant to support, spanning traditional interventional clinical trials, clinical studies like longitudinal cohorts and genetic studies, integrated mechanistic studies that connect clinical outcomes to underlying biology, and work aimed at identifying and validating biomarkers or surrogate endpoints.
From an applicant standpoint, this is a sizeable single-award program with an expected one award and an estimated total funding level of $16.5 million, with an award ceiling of $16.5 million. There is no cost sharing or matching requirement listed. The activity category is health, and the CFDA numbers noted are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research). The opportunity was posted March 26, 2014, with an original and current closing date of July 18, 2014, and it was archived August 18, 2014.
Eligibility is broad across many domestic organization types, including public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) nonprofits), small businesses and other for-profit organizations (other than small businesses are listed as eligible as well), and various government entities (state, county, city/township, special district, and independent school districts), along with tribal organizations and authorities. The eligibility language also highlights multiple institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, and it includes faith-based or community-based organizations and eligible federal agencies. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible; however, foreign components as defined by NIH policy are allowed, which typically means a U.S.-based applicant may include certain foreign components when justified and compliant with NIH rules.
Overall, this FOA is less about proposing a single new hypothesis-driven research project and more about proposing a high-capacity, quality-driven coordinating center that can deliver consistent statistical rigor, strong data systems, effective multi-site operations, and reliable safety and monitoring processes across a diverse set of DAIT clinical research activities in allergy/asthma, autoimmunity, and transplantation.
Frequently Asked Questions (FAQs)
What is the RFA-AI-14-016 funding opportunity?
RFA-AI-14-016 is a National Institutes of Health (NIH) cooperative agreement to fund a single Statistical and Clinical Coordinating Center (UM2) for the NIAID Division of Allergy, Immunology and Transplantation (DAIT). The purpose is to create one centralized hub that provides the operational and analytic backbone for multiple DAIT-supported clinical research efforts.
Which NIH institute and division are sponsoring this opportunity?
The opportunity is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), specifically its Division of Allergy, Immunology and Transplantation (DAIT).
What is being funded: a research project or a coordinating center?
This FOA is primarily about funding a high-capacity, quality-driven coordinating center rather than proposing a single hypothesis-driven research project. The award supports centralized coordination services that enable multiple studies to be designed well, launched efficiently, run safely and compliantly, and analyzed rigorously.
What does it mean that this is a cooperative agreement?
Because it is a cooperative agreement, NIH staff are expected to be actively involved in collaboration with the awardee. The relationship is not hands-off; it typically includes shared planning, frequent coordination, and ongoing NIH involvement in major scientific and operational decisions, especially around protocol design, safety oversight, and data/analysis standards.
How many awards are expected?
The FOA describes this as a single-award program with an expected one award.
What is the estimated total funding and the award ceiling?
The estimated total funding level is $16.5 million, and the award ceiling is also $16.5 million.
Is cost sharing or matching required?
No cost sharing or matching requirement is listed for this opportunity.
What is the activity category for this grant?
The activity category is health.
What CFDA numbers are associated with this opportunity?
The CFDA numbers noted are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
When was the opportunity posted and when did it close?
The opportunity was posted on March 26, 2014. The original and current closing date is July 18, 2014. It was archived on August 18, 2014.
What is the overall mission of the coordinating center under this FOA?
The coordinating center is intended to serve as a dedicated hub that supports DAIT clinical research efforts by providing strong statistical leadership, robust data systems, effective multi-site operations, safety oversight support, and reliable final analyses and reporting support across a diverse portfolio.
Which research areas does DAIT’s portfolio cover under this coordinating center?
The FOA describes DAIT’s portfolio as spanning studies in asthma and allergic diseases, autoimmune diseases, and transplantation.
What types of studies is the coordinating center expected to support?
The scope is broad and includes traditional interventional clinical trials; clinical studies such as longitudinal cohorts and genetic studies; integrated mechanistic studies that connect clinical outcomes to underlying biology; and studies aimed at identifying and validating biomarkers or surrogate endpoints.
What does “end-to-end support” mean in this FOA?
“End-to-end support” refers to involvement across the full lifecycle of clinical research: upfront study design and protocol development, study start-up and conduct (including multi-site coordination), ongoing data management and monitoring, safety monitoring support, and final statistical analyses and reporting at study completion.
What statistical responsibilities are expected of the coordinating center during study design?
The FOA calls for statistical leadership in study design, including selecting endpoints, calculating sample sizes, developing randomization schemes, and planning interim monitoring. It also includes helping turn scientific aims into executable protocols and analysis plans.
What operational responsibilities are included for study start-up and conduct?
The coordinating center is expected to handle core operational functions such as study initiation, project management, and practical coordination to keep multi-site work moving on schedule.
What data management functions are expected?
The center is expected to build and maintain robust data management systems, including collection, cleaning, validation, and secure handling of study data. The FOA also emphasizes documentation and standards that make data usable across multiple studies and disease areas.
Does the coordinating center have responsibilities related to monitoring at clinical sites?
Yes. The FOA states the center supports monitoring activities at clinical sites, typically including ensuring adherence to protocols, performing data quality checks, and helping sites resolve issues quickly and consistently.
Is safety oversight part of the coordinating center’s scope?
Yes. Safety oversight is explicitly included. The coordinating center is expected to provide safety monitoring support, generally involving adverse event collection and reporting workflows, preparation of safety summaries for oversight bodies, and maintaining infrastructure needed for appropriate clinical trial oversight.
What is expected at the end of each study?
At the end of each study, the coordinating center is responsible for the final statistical analysis and for supporting interpretation and reporting of findings, with an emphasis on defensible, transparent results aligned with the pre-specified analysis approach.
Who is the coordinating center expected to work with?
The awardee is expected to work closely with NIAID program leadership and the various DAIT-supported research networks and study teams, with ongoing coordination and collaboration throughout planning and execution.
What kinds of organizations are eligible to apply?
Eligibility is broad across many domestic organization types, including public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) nonprofits), small businesses, other for-profit organizations, and various government entities (state, county, city/township, special district, and independent school districts), along with tribal organizations and authorities.
Are specific institution designations mentioned as eligible?
Yes. The eligibility language highlights institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions. It also includes faith-based or community-based organizations and eligible federal agencies.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed in any form?
Yes. The FOA notes that foreign components, as defined by NIH policy, are allowed. This typically means a U.S.-based applicant may include certain foreign components when justified and compliant with NIH rules.
What is the main differentiator of this FOA compared to typical research grants?
The differentiator is that the FOA is geared toward building and operating a centralized coordinating center that delivers consistent statistical rigor, strong data systems, multi-site operational coordination, and safety/monitoring processes across multiple DAIT-supported studies, rather than funding one discrete research study.
Browse more opportunities from the same category: Health
Next opportunity: Smart Growth Information Clearinghouse
Previous opportunity: Conservation Innovative Grants
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA AI 14 016
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA AI 14 016) also looked into and applied for these:
| Funding Opportunity |
|---|
| National Environmental Medicine Education and Consultation Project (NEMECP) Apply for CDC RFA TS14 1401 Funding Number: CDC RFA TS14 1401 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Reduce Hepatitis Infections by Treatment and Integrated Prevention Services (Hepatitis TIPS) among Non urban Young Persons Who Inject Drugs Apply for RFA PS 14 004 Funding Number: RFA PS 14 004 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $300,000 |
| National Diabetes Prevention Program Preventing Type 2 Diabetes Among People at High Risk Apply for CDC RFA DP12 121203CONT14 Funding Number: CDC RFA DP12 121203CONT14 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| High Impact Neuroscience Research Resource Grants (R24) Apply for RFA NS 14 006 Funding Number: RFA NS 14 006 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Clinical Studies of Mental Illness Not Involving Treatment Development, Efficacy, or Effectiveness Trials (Collaborative R01) Apply for PAR 14 165 Funding Number: PAR 14 165 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Service Area Competition Additional Area (SAC AA) Warrenton, GA Apply for HRSA 14 136 Funding Number: HRSA 14 136 Agency: Health Resources and Services Administration Category: Health Funding Amount: $1,185,045 |
| Biology of Manual Therapies (R21) Apply for PA 14 167 Funding Number: PA 14 167 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Biology of Manual Therapies (R01) Apply for PA 14 168 Funding Number: PA 14 168 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| The Affordable Care Act and What it Means for People with Disabilities Apply for NCD0114 Funding Number: NCD0114 Agency: National Council on Disability Category: Health Funding Amount: $135,000 |
| Fetal Alcohol Spectrum Disorders Practice and Implementation Centers Apply for CDC RFA DD14 1402 Funding Number: CDC RFA DD14 1402 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $275,000 |
| Improving Fetal Alcohol Spectrum Disorders Prevention and Practice through National Partnerships Apply for CDC RFA DD14 1403 Funding Number: CDC RFA DD14 1403 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| COMPREHENSIVE COMMUNITY HIV PREVENTION PROJECT FOR KEY AND VULNERABLE POPULATIONS (CP2) Apply for RFI CP2 TANZANIA Funding Number: RFI CP2 TANZANIA Agency: Agency for International Development Category: Health Funding Amount: $74,999,999 |
| Evaluation of Health Promotion and Prevention Programs for Blood Disorders Apply for CDC RFA DD14 1405 Funding Number: CDC RFA DD14 1405 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $600,000 |
| Maintenance and Enhancement of the Environmental Public Health Tracking Network Apply for CDC RFA EH14 1403 Funding Number: CDC RFA EH14 1403 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $900,000 |
| Innovative Programs to Enhance Research Training (IPERT) (R25) Apply for PAR 14 170 Funding Number: PAR 14 170 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Claude D. Pepper Older Americans Independence Centers (P30) Apply for RFA AG 15 003 Funding Number: RFA AG 15 003 Agency: National Institutes of Health Category: Health Funding Amount: $800,000 |
| HIV/AIDS Policy Initiative Building State, County and Local Public Health Infrastructure Apply for CDC RFA PS10 104505CONT14 Funding Number: CDC RFA PS10 104505CONT14 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Newborn Screening Data Repository and Technical Assistance Center Apply for HRSA 14 089 Funding Number: HRSA 14 089 Agency: Health Resources and Services Administration Category: Health Funding Amount: $850,000 |
| Behavioral Health Workforce Education and Training for Professionals Apply for HRSA 14 077 Funding Number: HRSA 14 077 Agency: Health Resources and Services Administration Category: Health Funding Amount: $480,000 |
| Behavioral Health Workforce Education and Training for Paraprofessionals Apply for HRSA 14 126 Funding Number: HRSA 14 126 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA AI 14 016", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.