Opportunity Information: Apply for PAR 10 041

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIDCR Small Research Grants for Data Analysis and Statistical Methodology applied to Genome wide Data (R03)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
  • This funding opportunity was created on Dec 1, 2009 and posted on Dec 1, 2009.
  • Applicants must submit their applications by Jan 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Public and State controlled institutions of higher education Small businesses Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments For profit organizations other than small businesses.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The NIDCR Small Research Grants for Data Analysis and Statistical Methodology applied to Genome wide Data (R03) (Funding Opportunity Number PAR-10-041) was a discretionary National Institutes of Health grant opportunity designed to fund smaller, focused projects that make strong scientific use of existing genome-wide datasets in ways that are directly relevant to human dental, oral, or craniofacial conditions and traits. Rather than supporting new genome-wide data collection, the emphasis is on secondary analyses of already-available genome-wide data and on developing, adapting, or testing statistical methods that improve how genome-wide data can be analyzed and interpreted for oral and craniofacial research questions. In practical terms, applicants were expected to propose work such as reanalyzing previously generated GWAS or other genome-wide datasets to discover new genetic associations, validating or refining earlier findings using alternative analytic strategies, integrating genome-wide data with phenotypic or clinical measures related to dental or craniofacial outcomes, or creating and evaluating analytic methodology that addresses common challenges in genome-wide studies (for example, handling population structure, multiple testing, rare variant analysis, missing data, phenotype definition issues, or other sources of bias and uncertainty).

The award mechanism for this program was the NIH Small Research Grant (R03), which is typically used for short-term, limited-scope projects that can be completed with a modest budget and a clearly defined set of aims. The listed award ceiling for this opportunity was $200,000, consistent with the R03 concept of supporting compact projects where the key value comes from the idea, the analytic plan, and the rigor of the approach rather than from large-scale data generation. The announcement noted that the total amount ultimately awarded and the number of awards made would vary and would depend on the scientific merit of submitted applications as well as the availability of funds in NIDCRs general funding pool. It also made clear that project size and duration could differ across awards because proposals could range from targeted secondary analyses to more methodological efforts, each with different staffing, computational, and time requirements.

Eligibility under PAR-10-041 was broad and included many types of organizations that commonly apply for NIH funding. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, small businesses, and other for-profit organizations (with small businesses explicitly included), as well as nonprofit organizations with and without 501(c)(3) status. Governmental and community-based entities were also eligible, including state governments, federally recognized Native American tribal governments, and Native American tribal organizations that are not federally recognized. The opportunity also identified additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), U.S. territories or possessions, regional organizations, and eligible federal agencies. Notably, non-U.S. entities (foreign organizations) were listed as eligible as well. The opportunity did not require cost sharing or matching funds.

Administratively, the program was posted on December 1, 2009, and the original and final closing date listed was January 7, 2013, with an archive date of February 7, 2013, indicating that the announcement is no longer active. The associated CFDA number was 93.121, Oral Diseases and Disorders Research, and the sponsoring agency was the National Institutes of Health, with the program housed in NIDCR. For further details at the time, applicants were directed to the full FOA text on the NIH Grants Guide website, and technical access issues were handled through the NIH Office of Extramural Research (OER) webmaster contact provided in the listing.

Frequently Asked Questions (FAQs)

What is the PAR-10-041 funding opportunity?

PAR-10-041 is the NIDCR Small Research Grants for Data Analysis and Statistical Methodology applied to Genome wide Data (R03). It was a discretionary National Institutes of Health (NIH) grant opportunity designed to support smaller, focused projects that make strong scientific use of existing genome-wide datasets in ways directly relevant to human dental, oral, or craniofacial conditions and traits.

Which NIH institute sponsored this opportunity?

The sponsoring agency was the National Institutes of Health (NIH), and the program was housed within the National Institute of Dental and Craniofacial Research (NIDCR).

What grant mechanism was used for this program?

This program used the NIH Small Research Grant (R03) mechanism, which is generally intended for short-term, limited-scope projects with a modest budget and clearly defined aims.

What was the primary purpose of the program?

The primary purpose was to fund secondary analyses of already-available genome-wide data and to support developing, adapting, or testing statistical methods that improve how genome-wide data can be analyzed and interpreted for oral and craniofacial research questions.

Does the program fund new genome-wide data collection?

No. The emphasis was on analyzing existing genome-wide datasets rather than generating new genome-wide data.

What kinds of projects were expected to be competitive or appropriate under this FOA?

Examples of expected project types included reanalyzing previously generated genome-wide association studies (GWAS) or other genome-wide datasets to discover new genetic associations; validating or refining earlier findings using alternative analytic strategies; integrating genome-wide data with phenotypic or clinical measures related to dental or craniofacial outcomes; and creating and evaluating analytic methodologies that address common challenges in genome-wide studies.

What methodological challenges did the FOA highlight as relevant?

The FOA specifically mentioned methodological work addressing challenges such as population structure, multiple testing, rare variant analysis, missing data, phenotype definition issues, and other sources of bias and uncertainty in genome-wide studies.

What is the maximum award amount (award ceiling) listed for this opportunity?

The listed award ceiling was $200,000, consistent with the R03 concept of supporting compact projects where the key value is the idea, analytic plan, and rigor rather than large-scale data generation.

Was the total funding or number of awards guaranteed?

No. The announcement stated that the total amount awarded and the number of awards made would vary based on the scientific merit of applications and the availability of funds in NIDCR's general funding pool.

Could project size and duration vary between awards?

Yes. The announcement indicated that project size and duration could differ across awards because proposals could range from targeted secondary analyses to more methodological efforts, which can involve different staffing, computational, and time requirements.

Was cost sharing or matching funds required?

No. The opportunity did not require cost sharing or matching funds.

Who was eligible to apply?

Eligibility was broad and included public and state-controlled institutions of higher education, private institutions of higher education, small businesses and other for-profit organizations (with small businesses explicitly included), and nonprofit organizations with or without 501(c)(3) status.

Were government or community-based organizations eligible?

Yes. Eligible applicants included state governments, federally recognized Native American tribal governments, and Native American tribal organizations that are not federally recognized, as well as other governmental and community-based entities listed in the announcement.

Were minority-serving institutions specifically mentioned as eligible?

Yes. The eligible categories listed included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).

Were U.S. territories or regional organizations eligible?

Yes. The announcement listed U.S. territories or possessions and regional organizations among the eligible applicant categories.

Were federal agencies eligible to apply?

Yes. Eligible federal agencies were included in the listed eligible applicant categories.

Could non-U.S. (foreign) organizations apply?

Yes. Non-U.S. entities (foreign organizations) were listed as eligible.

When was the funding opportunity posted?

The program was posted on December 1, 2009.

What were the closing dates for applications?

The original and final closing date listed was January 7, 2013.

Is this funding opportunity still active?

No. The listing indicated an archive date of February 7, 2013, which reflects that the announcement is no longer active.

What is the Funding Opportunity Number for this announcement?

The Funding Opportunity Number was PAR-10-041.

What CFDA number was associated with this opportunity?

The associated CFDA number was 93.121, Oral Diseases and Disorders Research.

Where were applicants directed for full details?

Applicants were directed to the full Funding Opportunity Announcement (FOA) text on the NIH Grants Guide website for details.

Who handled technical access issues related to the listing?

Technical access issues were handled through the NIH Office of Extramural Research (OER) webmaster contact provided in the listing.

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