Opportunity Information: Apply for PAR 11 306

  • The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "NIDDK Central Repositories Non renewable Sample Access (X01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
  • This funding opportunity was created on Aug 12, 2011 and posted on Aug 12, 2011.
  • Applicants must submit their applications by Jul 2, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Independent school districts Special district governments City or township governments County governments Small businesses For profit organizations other than small businesses Private institutions of higher education State governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Apply for PAR 11 306

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Opportunity Summary:

The NIDDK Central Repositories Non-renewable Sample Access (X01) opportunity (Funding Opportunity Number PAR-11-306) is an NIH discretionary grant mechanism designed to help investigators obtain access to scarce, non-renewable biospecimens and associated data that are stored in the NIDDK Central Repositories. The repositories contain materials collected through numerous major clinical studies supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the intent of this program is to enable new scientific questions to be answered by leveraging these existing, high-value samples rather than initiating new and costly sample collection efforts. A key feature of this announcement is the focus on non-renewable samples, meaning specimens that are limited in quantity and cannot be replaced once used, which makes careful justification and feasibility especially important.

Applicants use this FOA to request specific samples from one or more NIDDK-supported studies and to link those samples to available clinical or study data housed by the repository. Details about what studies are represented, what specimen types exist (for example, serum, plasma, DNA, urine, tissue depending on the parent study), and what corresponding datasets are available are maintained on the NIDDK repository website at https://www.niddkrepository.org. Because access depends on whether the requested specimens still exist in sufficient quantity and are appropriate for the proposed analyses, the application must include documentation from the NIDDK Central Repositories confirming sample availability. In practical terms, this means investigators are expected to work with the repository ahead of submission to identify feasible requests, confirm counts and volumes, and ensure the proposal aligns with the repositorys access policies.

The award is categorized under the NIH grants framework as a grant funding instrument with an activity category aligned with NIDDKs mission space (CFDA 93.847, Diabetes, Digestive, and Kidney Diseases Extramural Research) and is listed under the broader activity category of Food and Nutrition Health. There is no cost sharing or matching requirement, which lowers barriers for applicants who may not have institutional funds set aside to meet a match. The announcement was posted on August 12, 2011, with an original and final closing date of July 2, 2014, and it was archived on August 2, 2014, meaning it is no longer open for new submissions under that specific FOA number and dates, though similar repository access opportunities may exist under updated NIH announcements.

Eligibility is broad and includes a wide range of domestic and non-domestic entities. Eligible applicants listed include public and private institutions of higher education, state and local governments, tribal governments and tribal organizations, independent school districts, special district governments, public housing authorities/Indian housing authorities, small businesses, and for-profit organizations other than small businesses. It also explicitly includes nonprofit organizations both with and without 501(c)(3) status. The eligibility section further clarifies that additional applicant types are acceptable, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components as defined in the NIH Grants Policy Statement are allowed, which reflects NIHs willingness to support scientifically sound use of these unique samples regardless of geography, provided policy requirements are met.

Overall, this opportunity is best understood as a structured access pathway rather than a traditional new-sample-collection research grant: investigators propose a study that depends on existing repository specimens and data, demonstrate that the required non-renewable materials are available, and justify why those samples are necessary to answer the research question. Anyone seeking to understand the specifics of what can be requested is directed to the NIDDK repository site for up-to-date study and sample inventories, and the archived full announcement is linked through NIH at http://grants.nih.gov/grants/guide/pa-files/PAR-11-306.html. For technical issues accessing the announcement, NIH provides contact through the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

FAQs: NIDDK Central Repositories Non-renewable Sample Access (X01) (PAR-11-306)

What is the NIDDK Central Repositories Non-renewable Sample Access (X01) opportunity?

It is an NIH discretionary grant mechanism that allows investigators to request access to scarce, non-renewable biospecimens and associated data stored in the NIDDK Central Repositories. The goal is to enable new research using existing high-value samples collected in major NIDDK-supported clinical studies, instead of launching new and costly sample collection efforts.

What does "non-renewable" mean in this program?

"Non-renewable" refers to specimens that are limited in quantity and cannot be replaced once used. Because these samples are scarce, requests typically need careful justification and a clear feasibility plan, including confirmation that enough sample exists for the proposed analyses.

What is the Funding Opportunity Number (FOA) for this program?

The FOA is PAR-11-306, titled "NIDDK Central Repositories Non-renewable Sample Access (X01)."

Is this FOA still open for applications?

No. The announcement was archived on August 2, 2014. The original and final closing date listed was July 2, 2014, meaning it is no longer open for new submissions under that FOA number and those dates.

Where can someone find the archived full announcement?

The archived announcement is available through NIH at: http://grants.nih.gov/grants/guide/pa-files/PAR-11-306.html

What kinds of materials are stored in the NIDDK Central Repositories?

The repositories contain biospecimens and related materials collected through numerous major clinical studies supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

What types of biospecimens might be available through the repository?

Specimen types vary by the parent study and may include serum, plasma, DNA, urine, and tissue, among others. Availability depends on the specific NIDDK-supported study and what remains in inventory.

Can applicants request both samples and data?

Yes. Applicants use this FOA to request specific samples from one or more NIDDK-supported studies and link those samples to available clinical or study data housed by the repository.

How do applicants know which studies, specimen types, and datasets are available?

Details about represented studies, specimen types, and corresponding datasets are maintained on the NIDDK repository website at https://www.niddkrepository.org

Is sample access guaranteed if an application is submitted?

No. Access depends on whether the requested specimens still exist in sufficient quantity and whether they are appropriate for the proposed analyses, consistent with the repository's access policies.

What documentation is required regarding sample availability?

The application must include documentation from the NIDDK Central Repositories confirming sample availability. This reflects the program's emphasis on feasibility and responsible use of non-renewable materials.

Should investigators contact the repository before submitting an application?

Yes. Investigators are expected to work with the repository ahead of submission to identify feasible requests, confirm counts and volumes, and ensure the proposal aligns with the repository's access policies.

What is the main purpose of using existing repository specimens instead of collecting new ones?

The intent is to answer new scientific questions by leveraging existing, high-value samples collected through major NIDDK-supported studies, avoiding new and costly sample collection efforts when appropriate samples already exist.

Is this opportunity more like a traditional research grant or more like an access pathway?

It is best understood as a structured access pathway rather than a traditional new-sample-collection research grant. Investigators propose a study that depends on existing repository specimens and data and justify why those specific non-renewable materials are necessary.

Which NIH institute is associated with these repositories and this opportunity?

The opportunity is associated with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

What CFDA number is associated with this opportunity?

The listing includes CFDA 93.847, Diabetes, Digestive, and Kidney Diseases Extramural Research.

Is there a cost sharing or matching requirement?

No. The opportunity states there is no cost sharing or matching requirement.

What kinds of organizations are eligible to apply?

Eligibility is broad and includes domestic and non-domestic entities. Examples listed include public and private institutions of higher education, state and local governments, tribal governments and tribal organizations, independent school districts, special district governments, public housing authorities/Indian housing authorities, small businesses, for-profit organizations other than small businesses, and nonprofit organizations with or without 501(c)(3) status.

Are specific institution types (like HBCUs, HSIs, or TCCUs) mentioned as eligible?

Yes. The eligibility section explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).

Are faith-based or community-based organizations eligible?

Yes. Faith-based or community-based organizations are explicitly listed as eligible applicant types.

Can foreign institutions apply?

Yes. Foreign institutions may apply, and non-U.S. components of U.S. organizations are eligible.

Are foreign components allowed under this opportunity?

Yes. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Are U.S. territories or possessions eligible to apply?

Yes. U.S. territories or possessions are explicitly listed among acceptable applicant types.

Are eligible federal agencies allowed to apply?

Yes. Eligible federal agencies are listed among acceptable applicant types.

What activity or mission area is this opportunity associated with?

It is aligned with NIDDK's mission space and is listed under a broader activity category of Food and Nutrition Health.

What is the key feasibility consideration emphasized in the FOA?

A central feasibility consideration is that the requested non-renewable specimens must still exist in sufficient quantity for the proposed work. The FOA emphasizes confirming availability with the repository and providing documentation of that availability in the application.

Where should applicants go for up-to-date sample inventories and study listings?

Applicants are directed to the NIDDK repository website for up-to-date study and sample inventories: https://www.niddkrepository.org

Who should be contacted for technical issues accessing the NIH announcement page?

For technical issues accessing the announcement, NIH provides the NIH Office of Extramural Research (OER) webmaster contact: FBOWebmaster@OD.NIH.GOV

When was this FOA posted, and what were the closing dates?

The announcement was posted on August 12, 2011. The original and final closing date listed was July 2, 2014, and the FOA was archived on August 2, 2014.

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