Opportunity Information: Apply for PAR 16 127

  • The HHS-NIH11 in the food and nutrition, health sector is offering a public funding opportunity titled "NIDDK Program Projects (P01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
  • This funding opportunity was created on Mar 09, 2016 and posted on Mar 09, 2016.
  • Applicants must submit their applications by May 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $6,250,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for PAR 16 127

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Opportunity Summary:

The NIDDK Program Projects (P01) opportunity (Funding Opportunity Number PAR 16 127) is a discretionary NIH grant mechanism designed to support large, investigator-initiated program project applications that bring together multiple related research efforts under one coordinated umbrella. The core idea is to fund a set of scientifically linked projects that share a common theme and benefit from close collaboration, shared resources, and an overall leadership plan. This type of award is typically used when a research question is big enough that it is best tackled by several complementary projects working in parallel, rather than a single stand-alone study.

The program is sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) within HHS/NIH (listed as HHS-NIH11) and focuses on topics that align with NIDDKs mission. Proposed programs should fit within scientific areas such as diabetes, selected endocrine and metabolic diseases, obesity, digestive diseases and nutrition, and kidney, urologic, and hematologic diseases. The announcement also emphasizes innovation and impact, specifically encouraging new approaches to prevent, treat, and cure these conditions. Clinical research is explicitly included, so applicants can propose human-focused studies when appropriate, as long as they are well justified and aligned with the institutes priorities. NIDDK provides additional detail on its scientific program areas through its public research areas page.

In terms of who can apply, eligibility is broad and includes many types of domestic organizations and governmental entities. Eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions when noted in the category); for-profit organizations other than small businesses; and small businesses. The notice also references an "Others" category with eligibility clarified in the full text, which typically means additional entity types may be allowed if they meet NIH policy requirements described in the complete announcement.

The activity category for this opportunity is listed under Food and Nutrition and Health, with CFDA number 93.847. The funding instrument type is a grant. The opportunity was posted and created on March 9, 2016, and the original and current closing date shown is May 7, 2019. The award ceiling is listed as $6,250,000, indicating the maximum amount expected per award under the terms described in the announcement, although actual budgets in NIH mechanisms often depend on the scope, duration, and negotiated final budget. The number of expected awards is not provided in the supplied record, which generally means applicants should not assume a specific success rate and should focus on the strength, alignment, and integration of the proposed program.

Overall, this FOA is aimed at research teams capable of organizing a multi-project, collaborative program that advances NIDDK-relevant science in a cohesive way, ideally producing outcomes that would be difficult to achieve through smaller, independent projects.

FAQs: NIDDK Program Projects (P01) - PAR 16-127

What is the NIDDK Program Projects (P01) opportunity (PAR 16-127)?

This is a discretionary NIH grant mechanism sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It supports large, investigator-initiated program project applications that combine multiple related research efforts into one coordinated program.

What is the main purpose of a P01 (Program Project) award under this opportunity?

The purpose is to fund a set of scientifically linked projects that share a common theme and benefit from close collaboration, shared resources, and an overall leadership plan. It is intended for research questions that are best addressed by several complementary projects working together rather than by a single stand-alone study.

Who sponsors this funding opportunity?

The sponsor is the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), within HHS/NIH (listed as HHS-NIH11).

What types of research topics are a fit for this NIDDK P01 opportunity?

Programs should align with NIDDK's mission and may fall within scientific areas such as diabetes; selected endocrine and metabolic diseases; obesity; digestive diseases and nutrition; and kidney, urologic, and hematologic diseases.

Does the announcement encourage innovation?

Yes. The announcement emphasizes innovation and impact and encourages new approaches to prevent, treat, and cure the relevant conditions.

Is clinical (human) research allowed under this opportunity?

Yes. Clinical research is explicitly included, and applicants may propose human-focused studies when appropriate, as long as the work is well justified and aligned with NIDDK priorities.

What kind of grant mechanism is this?

The funding instrument type is a grant, and the mechanism is a Program Project (P01).

What is meant by "investigator-initiated" in this context?

It means the applicants propose the research program themselves, including the theme and the set of linked projects, rather than responding to a narrowly defined government-designed research plan.

What makes a P01 different from a single-project application?

A P01 is designed for a coordinated, multi-project program. The projects are expected to be scientifically linked under a common theme and strengthened through collaboration, shared resources, and an overall leadership plan.

Does the opportunity require that projects be coordinated under one umbrella?

Yes. The FOA describes a coordinated umbrella structure where multiple related research efforts are organized together, supported by collaboration and shared resources.

What kinds of organizations are eligible to apply?

Eligibility is broad and includes many domestic organizations and governmental entities, including:

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • Federally recognized Native American tribal governments
  • Other Native American tribal organizations
  • Public housing authorities and Indian housing authorities
  • Nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions when noted in the category)
  • For-profit organizations other than small businesses
  • Small businesses

What does the "Others" eligibility category mean?

The record references an "Others" category with eligibility clarified in the full text. In practice, this typically means additional entity types may be allowed if they meet NIH policy requirements described in the complete announcement.

What is the CFDA number for this opportunity?

The CFDA number listed is 93.847.

What activity category is this opportunity listed under?

The activity category is listed as Food and Nutrition and Health.

When was this opportunity posted?

The opportunity was posted and created on March 9, 2016.

What is the closing date shown for this opportunity?

The original and current closing date shown is May 7, 2019.

What is the maximum award amount (award ceiling) listed?

The award ceiling is listed as $6,250,000, which indicates the maximum amount expected per award under the terms described in the announcement.

Does the award ceiling guarantee that an award will be funded at that level?

No. The information provided notes that actual budgets in NIH mechanisms often depend on the scope, duration, and negotiated final budget.

How many awards does NIDDK expect to make under this FOA?

The number of expected awards is not provided in the supplied record.

Should applicants assume a particular success rate based on the information provided?

No. Because the number of expected awards is not provided, applicants should not assume a specific success rate and should focus on the strength, alignment, and integration of the proposed program.

What are the key characteristics of a strong program project concept based on the description?

Based on the description, a strong concept typically includes: multiple complementary projects; a clear, common scientific theme; close collaboration; shared resources that benefit the group; and an overall leadership plan to coordinate the program.

Where can applicants look for more detail on NIDDK scientific program areas?

The description notes that NIDDK provides additional detail through its public research areas page.

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Applicants also applied for:

Applicants who have applied for this opportunity (PAR 16 127) also looked into and applied for these:

Funding Opportunity
High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2) Apply for PAR 16 126

Funding Number: PAR 16 126
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: Case Dependent
Early-Stage Preclinical Validation of Therapeutic Leads for Diseases of Interest to the NIDDK (R01) Apply for PAR 16 121

Funding Number: PAR 16 121
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: Case Dependent
Limited Competition: Small Grant Program for NIDDK K01/K08/K23 Recipients (R03) Apply for PAR 16 148

Funding Number: PAR 16 148
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: $50,000
Advances in Polycystic Kidney Disease (R01) Apply for PA 16 159

Funding Number: PA 16 159
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: Case Dependent
Human Islet Distribution Coordinating Center (UC4) Apply for RFA DK 16 023

Funding Number: RFA DK 16 023
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: $1,300,000
Limited Competition: Rare Diseases Clinical Research Network (RDCRN) Project Supplements for Clinical Trials to Repurpose Drugs in Collaboration with E-Rare Awardees (Admin Supp) Apply for PA 16 183

Funding Number: PA 16 183
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: Case Dependent
NIDDK Short-Term Research Experience Program for Underrepresented Persons (STEP-UP) (R25) Apply for RFA DK 16 021

Funding Number: RFA DK 16 021
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: Case Dependent
NIDDK Mentored Research Scientist Development Award (K01) Apply for PAR 16 211

Funding Number: PAR 16 211
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: Case Dependent
Nutrition Obesity Research Centers (NORCs) (P30) Apply for RFA DK 16 006

Funding Number: RFA DK 16 006
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: Case Dependent
Standardization of C-peptide and HbA1c Measurements Program (UC4) Apply for RFA DK 16 011

Funding Number: RFA DK 16 011
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: $350,000
Diabetes Research Centers (P30) Apply for RFA DK 16 020

Funding Number: RFA DK 16 020
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: Case Dependent
Ancillary Studies to Identify Behavioral and/or Psychological Phenotypes Contributing to Obesity (R01) Apply for PAR 16 304

Funding Number: PAR 16 304
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: Case Dependent
Limited Competition for the Continuation of the Collaborative Islet Transplantation Registry (UC4) Apply for RFA DK 16 503

Funding Number: RFA DK 16 503
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: Case Dependent
Neurocognitive Effects of Glycemic Dysregulation in Type 1 Diabetes (DP3) Apply for RFA DK 16 007

Funding Number: RFA DK 16 007
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: $3,000,000
Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01) Apply for PAR 16 333

Funding Number: PAR 16 333
Agency: HHS-NIH11
Category: Food and Nutrition, Health
Funding Amount: Case Dependent
Pediatric Centers of Excellence in Nephrology (P50) Apply for RFA DK 16 032

Funding Number: RFA DK 16 032
Agency: Department of Health and Human Services, National Institutes of Health
Category: Food and Nutrition, Health
Funding Amount: $750,000
George M. O'Brien Kidney Research Core Centers (P30) Apply for RFA DK 16 031

Funding Number: RFA DK 16 031
Agency: Department of Health and Human Services, National Institutes of Health
Category: Food and Nutrition, Health
Funding Amount: $750,000
Promoting Organ and Tissue Donation Among Diverse Populations (R01) Apply for RFA DK 16 022

Funding Number: RFA DK 16 022
Agency: Department of Health and Human Services, National Institutes of Health
Category: Food and Nutrition, Health
Funding Amount: $150,000
Limited Competition for Data Coordinating Center (DCC) for NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24) Apply for RFA DK 16 510

Funding Number: RFA DK 16 510
Agency: Department of Health and Human Services, National Institutes of Health
Category: Food and Nutrition, Health
Funding Amount: $1,062,000
NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genetic Research Centers (GRCs) (U01) Apply for RFA DK 16 029

Funding Number: RFA DK 16 029
Agency: Department of Health and Human Services, National Institutes of Health
Category: Food and Nutrition, Health
Funding Amount: $293,000

 

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