Opportunity Information: Apply for PAR 10 200
Apply for PAR 10 200
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIGMS National Centers for Systems Biology (P50)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on May 19, 2010 and posted on May 19, 2010.
- Applicants must submit their applications by Oct 27, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $7,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The NIGMS National Centers for Systems Biology (P50) funding opportunity (PAR-10-200) is a National Institutes of Health discretionary grant program designed to support the creation of institutional Centers of Excellence in Systems Biology. Its central purpose is to build and strengthen systems biology capacity at applicant organizations by funding integrated, collaborative programs that combine cutting-edge research with research training and outreach. The scientific emphasis is on systems-level approaches to biomedical and biobehavioral questions that align with the National Institute of General Medical Sciences (NIGMS) mission, with NIGMS directing applicants to its website for the full scope of mission priorities (www.nigms.nih.gov). In practice, this means proposed centers are expected to pursue interdisciplinary, quantitative, and integrative biology that helps explain how complex biological functions emerge from networks of interacting components, rather than focusing only on isolated molecules or single pathways.
This opportunity uses the P50 Specialized Center Grant mechanism, which is typically structured to support a coordinated center that brings together multiple projects and shared resources under a unified leadership and scientific vision. The intent is not simply to fund a set of independent research projects, but to enable a cohesive program where projects, cores, and administrative elements reinforce one another, creating an environment that can produce advances that might be difficult to achieve through standalone awards. The FOA explicitly highlights three interconnected pillars: pioneering research, research training, and outreach, signaling that applicants should think beyond experiments alone and demonstrate a plan for developing people and strengthening institutional systems biology culture and visibility.
In terms of funding scale, NIGMS anticipated making two awards under this announcement. The agency expected to commit up to $7,000,000 per year in total costs across awards, with an award ceiling that limits direct costs to $2,000,000 per year per center. The project period could be as long as five years, but not exceed five years, effectively allowing an award structure of up to $2 million in direct costs annually over a five-year term, subject to NIH policies and the proposed budget justification. There is no cost sharing or matching requirement, which reduces financial burden on applicant institutions and places the primary emphasis on scientific merit, program design, and institutional commitment.
Eligibility is broad and includes a range of higher education and nonprofit entities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with 501(c)(3) status (other than institutions of higher education), and nonprofits without 501(c)(3) status (other than institutions of higher education). The announcement also specifies additional eligible applicant categories, reflecting NIH interest in inclusivity across institution types, including Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and eligible agencies of the federal government. This breadth suggests NIGMS was seeking strong systems biology center proposals wherever the necessary expertise, infrastructure, and leadership could be assembled, including at institutions serving underrepresented or historically underserved communities.
Administratively, the opportunity is cataloged under CFDA 93.859 (Biomedical Research and Research Training) and was posted on May 19, 2010, with an original and current closing date of October 27, 2011, and an archive date of November 27, 2011. The full FOA text was hosted by NIH at http://grants.nih.gov/grants/guide/pa-files/PAR-10-200.html (as listed in the source data), and applicants needing technical help accessing the announcement were directed to the NIH Office of Extramural Research (OER) webmaster contacts. Overall, the program was positioned as a high-investment, center-based mechanism intended to accelerate systems biology through coordinated research, training, and outreach within the NIGMS scientific scope.
FAQs: NIGMS National Centers for Systems Biology (P50) - PAR-10-200
What is the NIGMS National Centers for Systems Biology (P50) opportunity (PAR-10-200)?
It is a National Institutes of Health (NIH) discretionary grant program from the National Institute of General Medical Sciences (NIGMS) intended to support the creation of institutional Centers of Excellence in Systems Biology. The opportunity uses the P50 Specialized Center Grant mechanism and is aimed at building and strengthening systems biology capacity at applicant organizations.
What is the main purpose of this funding opportunity?
The central purpose is to develop institutional strength in systems biology by funding integrated, collaborative programs that combine three elements: pioneering research, research training, and outreach. The goal is to create a coordinated center environment where projects and shared resources reinforce one another.
What type of grant mechanism is used?
This opportunity uses the P50 Specialized Center Grant mechanism. This mechanism is typically designed to support a coordinated center with multiple projects, shared resources (often organized as cores), and unified leadership under a single scientific vision.
Does this program fund independent research projects or a coordinated center program?
The intent is to fund a cohesive center program rather than a set of independent, unrelated research projects. The FOA emphasizes coordination among projects, cores, and administrative elements so the overall center can achieve advances that may be difficult through standalone awards.
What are the major program components emphasized by the FOA?
The FOA highlights three interconnected pillars: pioneering research, research training, and outreach. Applicants are expected to address all three areas as part of a center-based approach.
What scientific focus is expected for proposed centers?
Proposed centers are expected to pursue systems-level approaches to biomedical and biobehavioral questions aligned with the NIGMS mission. This generally means interdisciplinary, quantitative, and integrative biology aimed at explaining how complex biological functions emerge from networks of interacting components, rather than focusing solely on isolated molecules or single pathways.
How does NIGMS define alignment with its mission for this opportunity?
The announcement directs applicants to the NIGMS website for the full scope of mission priorities (www.nigms.nih.gov). Proposals should fit within that scope and apply systems biology approaches to questions relevant to NIGMS.
How many awards were anticipated under this announcement?
NIGMS anticipated making two awards under this funding opportunity announcement.
What is the total funding level NIGMS expected to commit each year?
NIGMS expected to commit up to $7,000,000 per year in total costs across the awards made under this announcement.
What is the budget ceiling for a single center award?
The award ceiling limits direct costs to $2,000,000 per year per center.
How long can the project period be?
The project period could be up to five years, but it could not exceed five years.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What kinds of organizations are eligible to apply?
Eligibility includes several categories of higher education and nonprofit entities, including:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
Are minority-serving institutions included as eligible applicants?
Yes. The announcement lists multiple eligible applicant categories that include institutions serving underrepresented or historically underserved communities, such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Are federal government agencies eligible to apply?
Yes. The announcement includes eligible agencies of the federal government among the eligible applicant categories.
What is the CFDA number associated with this opportunity?
The opportunity is cataloged under CFDA 93.859, titled Biomedical Research and Research Training.
When was the opportunity posted and when did it close?
The opportunity was posted on May 19, 2010. The original and current closing date listed is October 27, 2011. The archive date is November 27, 2011.
Where can applicants find the full Funding Opportunity Announcement (FOA) text?
The FOA was hosted by NIH at: http://grants.nih.gov/grants/guide/pa-files/PAR-10-200.html
Where were applicants directed for technical help accessing the announcement?
Applicants needing technical help accessing the announcement were directed to the NIH Office of Extramural Research (OER) webmaster contacts.
What does it mean that this is a "center-based" program?
In this context, a center-based program is designed around a unified leadership structure and scientific vision that coordinates multiple activities (such as research projects, shared resources, and administrative functions). The emphasis is on an integrated program that builds institutional capability in systems biology and creates a collaborative environment.
What institutional outcomes is this program designed to support?
Based on the description, the program is designed to build systems biology capacity at the applicant organization by supporting integrated research, training, and outreach activities that strengthen institutional expertise, culture, and visibility in systems biology.
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