Opportunity Information: Apply for PAR 12 187
Apply for PAR 12 187
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIGMS National Centers for Systems Biology (P50)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Aug 22, 2013 and posted on May 16, 2012.
- Applicants must submit their applications by Aug 22, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $10,000,000.00 to eligible and selected applicants.
- Eligible applicants include: For profit organizations other than small businesses Public housing authorities/Indian housing authorities City or township governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Special district governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses State governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIGMS National Centers for Systems Biology (P50) opportunity (Funding Opportunity Number PAR-12-187) is a discretionary NIH grant program designed to support the creation of Centers of Excellence in Systems Biology. Through this initiative, the National Institute of General Medical Sciences (NIGMS) seeks applications from institutions and organizations that can build and sustain a centralized, collaborative “center” structure focused on systems-level investigations of biomedical phenomena that align with the NIGMS mission. In practical terms, the program is meant to foster bold, integrated research approaches that look at biology as interacting networks and systems rather than isolated parts, while also building capacity through research training, education, and outreach activities.
A key emphasis of the announcement is that the proposed centers should do more than fund a collection of independent projects. The intent is to catalyze pioneering, collaborative science under a unified vision, where multiple investigators and disciplines come together to address complex biomedical questions using systems biology strategies (for example, combining computational modeling, quantitative experimentation, high-dimensional data analysis, and iterative hypothesis testing). Beyond research, the centers are also expected to strengthen the broader ecosystem around systems biology by contributing to training and workforce development, educational activities, and outreach efforts that help disseminate methods, tools, and findings to both the scientific community and other relevant audiences. The NIGMS mission is referenced as the guiding scope for the scientific areas the centers should tackle, with applicants directed to the NIGMS website (www.nigms.nih.gov) for the full mission description and priorities.
Administratively, this opportunity is offered by the National Institutes of Health under the “Health” funding activity category and is associated with CFDA number 93.859 (Biomedical Research and Research Training). The funding instrument is a grant, specifically using the P50 mechanism, which is commonly used by NIH to support specialized center grants that typically involve multiple integrated components under one overall center leadership and structure. The opportunity indicates an estimated total funding amount of $10,000,000, and it explicitly notes that there is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal matching funds as a condition of award.
Eligibility is broad and includes a wide range of U.S.-based organizational types across academic, nonprofit, governmental, and certain for-profit sectors. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education, nonprofits (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status), and for-profit organizations other than small businesses, as well as small businesses. Governmental eligibility spans state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The announcement also highlights eligibility for a number of institution types and community-focused entities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and certain Native American tribal governments and tribal organizations (including those other than federally recognized, as specified in the eligibility text). Federal agencies are also listed as eligible in the provided eligibility information.
At the same time, the announcement places clear limits on non-U.S. participation at the applicant level. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, the opportunity allows “foreign components” as defined in the NIH Grants Policy Statement, which typically means that while the primary applicant organization must be eligible and U.S.-based, certain parts of the research effort may include foreign involvement when appropriately justified and structured under NIH policy.
Key timeline details in the source data include an initial posted date of May 16, 2012, with administrative dates showing a creation date of Aug 22, 2013, an original closing date of Oct 23, 2014, a current closing date of Aug 22, 2013, and an archive date of Sep 22, 2013. The full funding announcement and official requirements, expectations, and application instructions are linked through NIH at http://grants.nih.gov/grants/guide/pa-files/PAR-12-187.html. For technical issues accessing or linking to the announcement, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, PAR-12-187 is best understood as a center-building opportunity: it aims to create durable, high-impact systems biology hubs that push the science forward through integrated, collaborative research while also investing in training, education, and outreach tied to NIGMS-relevant biomedical questions.
FAQs: NIGMS National Centers for Systems Biology (P50) - PAR-12-187
What is the PAR-12-187 funding opportunity?
PAR-12-187 is an NIH funding opportunity from the National Institute of General Medical Sciences (NIGMS) to support the creation of National Centers for Systems Biology using the P50 specialized center grant mechanism.
What is the purpose of this grant program?
The program is intended to build Centers of Excellence in Systems Biology that pursue systems-level investigations of biomedical phenomena aligned with the NIGMS mission. It emphasizes bold, integrated research approaches and a centralized, collaborative center structure rather than a collection of unrelated projects.
What does NIGMS mean by “systems biology” in this announcement?
Based on the announcement description, systems biology is framed as studying biology as interacting networks and systems rather than isolated parts, often using integrated strategies such as computational modeling, quantitative experimentation, high-dimensional data analysis, and iterative hypothesis testing.
What makes a “center” different from multiple independent research projects?
The opportunity stresses that proposed centers should not simply fund separate investigator-led projects. Instead, they should catalyze pioneering collaborative science under a unified vision, with multiple investigators and disciplines working together through a centralized center structure.
What kinds of activities are centers expected to include beyond research?
In addition to integrated systems biology research, centers are expected to contribute to research training and workforce development, educational activities, and outreach that helps disseminate methods, tools, and findings to the scientific community and other relevant audiences.
Who is the sponsoring agency and what is the funding category?
The sponsoring agency is the National Institutes of Health (NIH), and the funding activity category is listed as “Health.” The institute specifically referenced for the program goals is NIGMS.
What is the funding mechanism for this opportunity?
The funding instrument is a grant using the NIH P50 mechanism, which is typically used to support specialized center grants with multiple integrated components under an overall center leadership and structure.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.859, Biomedical Research and Research Training.
How much funding is available?
The opportunity lists an estimated total funding amount of $10,000,000.
Is cost sharing or matching required?
No. The opportunity explicitly states there is no cost sharing or matching requirement.
What types of organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based organization types across academic, nonprofit, governmental, and for-profit sectors. Examples listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and certain nonprofits without 501(c)(3)), for-profit organizations (including small businesses), and several types of governmental entities.
Are small businesses eligible?
Yes. Small businesses are listed as eligible applicants in the provided eligibility information.
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations other than small businesses, and it also separately includes small businesses.
What kinds of government entities are eligible?
The eligibility information includes state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are minority-serving institutions and community-focused organizations eligible?
Yes. The opportunity highlights eligibility for institution and community-focused categories including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, among others.
Are U.S. territories and regional organizations eligible?
Yes. The eligibility text includes U.S. territories or possessions and regional organizations.
Are Native American tribal governments and tribal organizations eligible?
Yes. The eligibility information includes certain Native American tribal governments and tribal organizations, including those other than federally recognized, as specified in the eligibility text.
Are federal agencies eligible to apply?
Yes. Federal agencies are listed as eligible in the provided eligibility information.
Can a foreign (non-U.S.) institution apply as the main applicant?
No. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as applicant organizations.
Can a non-U.S. component of a U.S. organization apply?
No. The opportunity states that non-domestic components of U.S. organizations are also not eligible to apply as the applicant.
Does the opportunity allow any foreign involvement at all?
Yes. While foreign institutions cannot apply as the primary applicant, the announcement allows “foreign components” as defined in the NIH Grants Policy Statement, meaning foreign involvement may be included in the research effort when appropriately justified and structured under NIH policy.
What scientific scope should proposed centers address?
The announcement indicates that the scientific areas should align with the NIGMS mission and directs applicants to the NIGMS website (www.nigms.nih.gov) for the full mission description and priorities.
Where can applicants find the official funding announcement and application instructions?
The full funding announcement is available through NIH at http://grants.nih.gov/grants/guide/pa-files/PAR-12-187.html.
What dates are listed for this opportunity?
The source data includes an initial posted date of May 16, 2012, an administrative creation date of Aug 22, 2013, an original closing date of Oct 23, 2014, a current closing date of Aug 22, 2013, and an archive date of Sep 22, 2013.
Who should be contacted for technical issues with accessing the announcement link?
For technical issues accessing or linking to the announcement, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the core goal of PAR-12-187 in plain terms?
It is a center-building opportunity designed to create durable, high-impact systems biology hubs that advance integrated, collaborative research while also investing in training, education, and outreach tied to NIGMS-relevant biomedical questions.
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