Opportunity Information: Apply for RFA DE 12 008
Apply for RFA DE 12 008
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "NIH Blueprint for Neuroscience Research Grand Challenge on the Transition from Acute to Chronic Neuropathic Pain (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.361 Nursing Research 93.389 National Center for Research Resources 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
- This funding opportunity was created on Jun 30, 2011 and posted on Jun 30, 2011.
- Applicants must submit their applications by Oct 4, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Eligible applicants include: Private institutions of higher education Small businesses For profit organizations other than small businesses Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments State governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Special district governments Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.
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Opportunity Summary:
The funding opportunity titled "NIH Blueprint for Neuroscience Research Grand Challenge on the Transition from Acute to Chronic Neuropathic Pain (R01)" (Funding Opportunity Number RFA-DE-12-008) was a National Institutes of Health (NIH) initiative released under the NIH Blueprint for Neuroscience Research. The Blueprint is a cross-NIH collaboration involving 16 NIH Institutes, Centers, and Offices that pool resources and align priorities to speed up neuroscience discovery and reduce the overall burden of nervous system disorders. In practical terms, this FOA was designed to attract strong, hypothesis-driven research projects that could move the field forward on a difficult, high-impact problem: understanding why and how neuropathic pain that starts out as an acute response after nerve injury becomes persistent, chronic pain in some individuals.
This announcement used the R01 grant mechanism, meaning it supported full-scale, investigator-initiated research projects rather than small pilot awards or purely exploratory mechanisms. The focus on a "Grand Challenge" signals that NIH was looking for ambitious and potentially transformative work, likely including integrative approaches that connect mechanisms across levels of analysis (for example, molecular and cellular pathways, circuit-level neurobiology, immune and glial contributions, and behavioral or clinical correlates). The public-health motivation behind the FOA is clear: chronic neuropathic pain is common, difficult to treat, and strongly linked to disability and reduced quality of life, so identifying the key biological and temporal drivers of the transition from acute to chronic pain could open the door to earlier interventions, better targets for therapy, and improved prevention strategies.
From an administrative and funding standpoint, this was a discretionary grant opportunity with no cost-sharing or matching requirement. NIH listed an estimated total funding amount of $2,500,000 for the FOA, indicating a finite pool intended to support a limited number of awards. The opportunity was posted on June 30, 2011, with an application closing date of October 4, 2011, and an archive date of November 4, 2011. As an archived FOA, it is no longer open for applications, but it remains useful as a reference point for the kinds of priorities and project characteristics NIH sought in this research area.
The FOA was associated with a broad set of CFDA program areas, reflecting the NIH Blueprint's multi-Institute nature and the reality that neuropathic pain research cuts across many missions. The listed CFDA numbers include programs connected to oral health and pain (93.121), communication disorders (93.173), complementary and integrative health (93.213), mental health (93.242), alcohol (93.273), drug abuse and addiction (93.279), technology innovations for human health (93.286), nursing research (93.361), research resources (93.389), neuroscience and neurological disorders (93.853), general biomedical research and training (93.859), child health and human development (93.865), aging (93.866), and vision research (93.867). This breadth suggests NIH viewed the transition to chronic neuropathic pain as a neuroscience problem with wide clinical relevance, touching different organ systems, age groups, and comorbidities, and potentially benefiting from diverse methodological and translational perspectives.
Eligibility was expansive. Eligible applicants included private and public institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses and other for-profit entities, and a wide range of government bodies (state, county, city/township, special district governments, and others). The FOA also explicitly included independent school districts, public housing authorities/Indian housing authorities, and Native American tribal governments and organizations. Additional eligible applicant types listed included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Importantly, non-U.S. entities (foreign institutions) were eligible to apply, and non-U.S. components of U.S. organizations were also eligible. That combination of broad eligibility and the R01 mechanism indicates NIH wanted to draw from the widest possible pool of expertise, including international strengths, to tackle the scientific barriers involved in pinning down the determinants of pain chronification.
For access and support, NIH pointed applicants to the full announcement hosted on the NIH grants site (with an additional information link to the FOA page) and provided contact guidance through the NIH Office of Extramural Research (OER) Webmaster for technical issues accessing or linking to the announcement. Overall, the FOA can be understood as a time-limited, competitively funded call aimed at accelerating neuroscience discoveries specifically centered on the biological and temporal mechanisms that drive the shift from acute neuropathic pain to long-lasting chronic pain, using the standard R01 framework and leveraging the NIH Blueprint's multi-Institute collaboration to support high-impact work.
FAQs: NIH Blueprint Grand Challenge on the Transition from Acute to Chronic Neuropathic Pain (R01) (RFA-DE-12-008)
What is this funding opportunity?
This was an NIH Funding Opportunity Announcement (FOA) titled "NIH Blueprint for Neuroscience Research Grand Challenge on the Transition from Acute to Chronic Neuropathic Pain (R01)." The Funding Opportunity Number was RFA-DE-12-008. It was released under the NIH Blueprint for Neuroscience Research, a cross-NIH collaboration designed to accelerate neuroscience discovery and reduce the burden of nervous system disorders.
What scientific problem was NIH trying to address?
The FOA targeted a high-impact question in pain research: why and how neuropathic pain that begins as an acute response after nerve injury becomes persistent, chronic neuropathic pain in some individuals. The intent was to support research that clarifies the biological and temporal drivers of this transition (often described as pain "chronification").
What does "Grand Challenge" mean in this context?
Within this announcement, "Grand Challenge" signaled that NIH was looking for ambitious, potentially transformative projects that could move the field forward on a difficult problem. The description emphasizes strong, hypothesis-driven work and suggests interest in integrative research that connects mechanisms across multiple levels of analysis.
What kind of grant mechanism did this FOA use?
This FOA used the NIH R01 mechanism. That means it supported full-scale research projects rather than small pilots or purely exploratory awards. The R01 format is generally used for substantial, investigator-initiated research efforts.
What types of approaches were implied as a good fit?
Based on the FOA description, NIH appeared to encourage projects that integrate mechanisms across levels of analysis, such as molecular and cellular pathways, circuit-level neurobiology, immune and glial contributions, and behavioral or clinical correlates. The overall framing suggests multi-level, mechanistic work aimed at explaining the shift from acute to chronic neuropathic pain.
Why was this FOA important from a public health perspective?
The FOA highlighted that chronic neuropathic pain is common, difficult to treat, and strongly linked to disability and reduced quality of life. By identifying key biological and time-dependent drivers of the acute-to-chronic transition, the research supported under this FOA was intended to help enable earlier interventions, better therapeutic targets, and improved prevention strategies.
How much funding was available under this FOA?
NIH listed an estimated total funding amount of $2,500,000 for this FOA, indicating a finite pool of funds intended to support a limited number of awards.
Was cost-sharing or matching required?
No. This was described as a discretionary grant opportunity with no cost-sharing or matching requirement.
When was the FOA posted and when did it close?
The opportunity was posted on June 30, 2011. The application closing date was October 4, 2011. The archive date was November 4, 2011.
Is this FOA still open for applications?
No. It is archived and no longer open for applications. It remains useful as a reference point for NIH priorities and the types of projects NIH sought in this area.
Who was behind this initiative?
This FOA was released under the NIH Blueprint for Neuroscience Research. The Blueprint is described as a cross-NIH collaboration involving 16 NIH Institutes, Centers, and Offices that pool resources and align priorities to accelerate neuroscience research.
Which research areas and NIH program categories did it connect to?
The FOA was associated with a broad set of CFDA program areas, reflecting the multi-Institute nature of the NIH Blueprint and the cross-cutting relevance of neuropathic pain research. The listed CFDA numbers were 93.121, 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.361, 93.389, 93.853, 93.859, 93.865, 93.866, and 93.867.
What does the broad set of CFDA numbers suggest about the scope?
The breadth suggests NIH viewed the transition to chronic neuropathic pain as a neuroscience problem with wide clinical relevance. The FOA framing indicates potential connections to different organ systems, age groups, comorbidities, and diverse methodological and translational perspectives.
What types of organizations were eligible to apply?
Eligibility was expansive. Eligible applicants included private and public institutions of higher education; nonprofit organizations (with and without 501(c)(3) status); small businesses and other for-profit entities; and many government bodies (including state, county, city/township, and special district governments, among others). The FOA also listed independent school districts, public housing authorities/Indian housing authorities, and Native American tribal governments and organizations as eligible.
Were minority-serving and mission-specific institutions eligible?
Yes. The FOA explicitly included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, and regional organizations as eligible applicant types.
Could federal agencies apply?
Yes. The eligibility list included eligible federal agencies.
Could organizations in U.S. territories or possessions apply?
Yes. The eligibility list included U.S. territories or possessions.
Were foreign (non-U.S.) institutions eligible to apply?
Yes. Non-U.S. entities (foreign institutions) were eligible to apply. The FOA also stated that non-U.S. components of U.S. organizations were eligible.
Where could applicants find the full announcement?
NIH directed applicants to the full announcement hosted on the NIH grants site, with an additional information link to the FOA page.
Who was listed for technical help accessing or linking to the FOA?
For technical issues accessing or linking to the announcement, NIH provided contact guidance through the NIH Office of Extramural Research (OER) Webmaster.
What is the main takeaway about the purpose of this FOA?
It was a time-limited, competitive call for R01 research projects aimed at accelerating neuroscience discoveries about the mechanisms and timing that drive the shift from acute neuropathic pain to persistent chronic pain, leveraging the NIH Blueprint's cross-Institute collaboration to support high-impact work.
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