Opportunity Information: Apply for RFA DE 11 002
Apply for RFA DE 11 002
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "NIH Blueprint for Neuroscience Research Grand Challenge on the Transition from Acute to Chronic Neuropathic Pain (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.361 Nursing Research 93.389 National Center for Research Resources 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
- This funding opportunity was created on May 7, 2010 and posted on May 7, 2010.
- Applicants must submit their applications by Sep 29, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education County governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Independent school districts Small businesses Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH Blueprint for Neuroscience Research Grand Challenge on the Transition from Acute to Chronic Neuropathic Pain (R01) (Funding Opportunity Number RFA-DE-11-002) is a National Institutes of Health grant opportunity designed to push forward research on why and how neuropathic pain shifts from a short-term, acute state into a long-lasting, chronic condition. It sits under the NIH Blueprint for Neuroscience Research, a coordinated effort in which 16 NIH Institutes, Centers, and Offices pool expertise and resources to speed up neuroscience discovery and reduce the impact of nervous system disorders. In practical terms, this FOA is trying to use the Blueprint structure to bring new perspectives and toolsets into pain research, especially ideas and methods that have been developed in other neuroscience areas where the progression from health to disease has been studied in depth.
A central focus of the program is collaboration, specifically encouraging teams that combine pain scientists with non-pain neuroscientists who have strong expertise in neuroplasticity. The underlying premise is that the move from acute to chronic neuropathic pain likely involves maladaptive plastic changes in the nervous system, and that researchers who study plasticity in other contexts (for example, learning and memory, addiction, sensory processing, neurodevelopment, or neurodegeneration) may offer concepts, experimental strategies, and analytic approaches that pain-focused labs do not typically use. The FOA emphasizes multi-Principal Investigator (multi-PI) applications and expects genuinely integrated, multidisciplinary projects rather than loosely connected efforts. The intended result is not only new findings, but also durable partnerships that continue beyond a single award and create a stronger cross-disciplinary community centered on the biology of chronic pain emergence.
The award mechanism is the NIH R01, meaning it supports hypothesis-driven, investigator-initiated research projects with substantial scope. Applicants can request direct costs that are appropriate for the science proposed, with a project period of up to five years. The opportunity listed an award ceiling of $500,000 (as provided in the source information), and the participating Blueprint Institutes indicated an intent to commit a total of $5 million in fiscal year 2011 to support approximately 7 to 10 awards. As with most NIH opportunities, actual awards depend on the availability of funds and whether enough high-quality, meritorious applications are received.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other than small businesses), local and state governmental entities, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The listing also explicitly notes additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), U.S. territories or possessions, faith-based or community-based organizations, regional organizations, federal agencies, and foreign (non-U.S.) entities. There is no cost sharing or matching requirement.
From an administrative standpoint, the opportunity was posted May 7, 2010, with an application closing date of September 29, 2010, and an archive date of October 29, 2010. It is categorized as a discretionary grant under the NIH, and it spans multiple CFDA program areas across NIH components (including neuroscience and neurological disorders, mental health, aging, child health, nursing research, alcohol and drug abuse programs, vision research, and others), reflecting the Blueprint-wide, cross-institute nature of the initiative. The full announcement was made available through the NIH grants guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-11-002.html, and general assistance was available via NIH Grants Info (301-435-0714) and the NIH Office of Extramural Research webmaster for technical linking issues.
Frequently Asked Questions (FAQs)
What is the full name of this NIH funding opportunity?
The opportunity is called the NIH Blueprint for Neuroscience Research Grand Challenge on the Transition from Acute to Chronic Neuropathic Pain (R01).
What is the funding opportunity number (FOA)?
The Funding Opportunity Number is RFA-DE-11-002.
What is the main purpose of this grant?
The purpose is to advance research on why and how neuropathic pain transitions from a short-term, acute state to a long-lasting, chronic condition. The FOA aims to push forward understanding of the biology underlying this transition, particularly as it relates to nervous system changes.
What is the programmatic focus of the research encouraged by this FOA?
A central focus is the transition from acute to chronic neuropathic pain and the idea that this shift likely involves maladaptive plastic changes in the nervous system (i.e., changes related to neuroplasticity).
How does the NIH Blueprint for Neuroscience Research relate to this opportunity?
This FOA sits under the NIH Blueprint for Neuroscience Research, a coordinated NIH effort where 16 Institutes, Centers, and Offices pool expertise and resources to accelerate neuroscience discovery and reduce the impact of nervous system disorders.
What kind of collaborative approach does the FOA emphasize?
The FOA emphasizes collaboration, especially teams that combine pain scientists with non-pain neuroscientists who have strong expertise in neuroplasticity. The intent is to bring perspectives, concepts, and tools into pain research that have been developed in other areas of neuroscience.
Does the FOA encourage multi-PI (multiple principal investigator) applications?
Yes. The FOA emphasizes multi-Principal Investigator (multi-PI) applications and expects genuinely integrated, multidisciplinary projects rather than loosely connected efforts.
What types of expertise are encouraged to be included on research teams?
The FOA specifically encourages pairing pain researchers with neuroscientists who study neuroplasticity in other contexts such as learning and memory, addiction, sensory processing, neurodevelopment, or neurodegeneration, with the goal of applying those concepts and methods to chronic pain emergence.
What is the expected outcome beyond new findings?
In addition to scientific discoveries, the FOA seeks to foster durable partnerships that continue beyond a single award and help build a stronger cross-disciplinary community focused on the biology of chronic pain emergence.
What award mechanism is used?
The award mechanism is the NIH R01.
What does it mean that the mechanism is an R01?
As described in the opportunity information provided, an R01 supports hypothesis-driven, investigator-initiated research projects with substantial scope.
How long can the project period be?
The project period can be up to five years.
How much funding can applicants request?
Applicants can request direct costs that are appropriate for the proposed science. The opportunity information provided also lists an award ceiling of $500,000.
How much total funding did the participating Institutes intend to commit?
The participating Blueprint Institutes indicated an intent to commit a total of $5 million in fiscal year 2011.
How many awards were expected?
The FOA anticipated supporting approximately 7 to 10 awards.
Are awards guaranteed if an application is submitted?
No. The information provided notes that actual awards depend on the availability of funds and whether enough high-quality, meritorious applications are received.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic organizations, including: public and private institutions of higher education; nonprofits (with and without 501(c)(3) status, other than institutions of higher education); for-profit organizations (including small businesses and other than small businesses); local and state government entities; independent school districts; public housing authorities/Indian housing authorities; and tribal governments and tribal organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. The listing explicitly includes foreign (non-U.S.) entities among eligible applicants.
Are specific types of institutions explicitly named as eligible?
Yes. The eligibility list explicitly notes additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), U.S. territories or possessions, faith-based or community-based organizations, regional organizations, federal agencies, and foreign entities.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
When was this funding opportunity posted?
It was posted on May 7, 2010.
What was the application closing date?
The application closing date was September 29, 2010.
What is the archive date for the opportunity?
The archive date was October 29, 2010.
How is this opportunity categorized?
It is categorized as a discretionary grant under the NIH.
Does the FOA span multiple NIH program areas?
Yes. It spans multiple CFDA program areas across NIH components, reflecting the Blueprint-wide, cross-institute nature of the initiative. The areas listed in the provided information include neuroscience and neurological disorders, mental health, aging, child health, nursing research, alcohol and drug abuse programs, vision research, and others.
Where can applicants find the full announcement?
The full announcement was made available through the NIH grants guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-11-002.html.
Who can be contacted for general assistance?
General assistance was available via NIH Grants Info at 301-435-0714.
Who can help with technical linking issues related to the announcement?
The NIH Office of Extramural Research webmaster was listed for technical linking issues.
What is the underlying scientific premise highlighted by the FOA?
The FOA highlights the premise that the transition from acute to chronic neuropathic pain likely involves maladaptive plastic changes in the nervous system, and that researchers with deep experience studying plasticity in other disease or functional contexts may bring valuable concepts, experimental strategies, and analytic approaches to pain research.
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