Opportunity Information: Apply for RFA RM 10 010
Apply for RFA RM 10 010
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH Common Fund Transformative Research Projects Program (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Aug 4, 2010 and posted on Aug 4, 2010.
- Applicants must submit their applications by Oct 27, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $25,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses State governments Independent school districts Public and State controlled institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments Private institutions of higher education Native American tribal governments (Federally recognized) Special district governments City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH Common Fund Transformative Research Projects Program (R01), announced under Funding Opportunity Number RFA-RM-10-010, is a discretionary NIH grant competition designed to back research ideas that are genuinely bold and unconventional. The central aim is to fund projects that are not just incremental improvements on existing work, but truly transformative efforts that could create entirely new scientific paradigms or seriously challenge prevailing assumptions. NIH is explicitly looking for exceptionally innovative, high-risk, and original approaches, with the expectation that the payoff could be a major, field-shaping advance. To be competitive, a proposed project needs to make a clear case that, if successful, it would have broad and significant impact across biomedical or behavioral research rather than being narrowly specialized.
This opportunity uses the standard NIH Research Project Grant mechanism (R01), meaning applicants are proposing a defined research project with a scientific plan, milestones, and an overall strategy consistent with the R01 format, but with the distinctive emphasis here on transformation and paradigm-shifting potential. The program sits within the NIH Common Fund, which generally supports cross-cutting research efforts intended to accelerate discovery across multiple NIH institutes and scientific areas.
Funding for the program was substantial for its time: NIH planned to commit a total of $25,000,000 in FY 2011 to support awards made through this announcement. The exact number of awards was not fixed and would depend on the size, scope, and overall merit of the applications received. Importantly, the announcement signaled willingness to support larger-than-typical projects as well: up to one third of the total program budget could be set aside for applications requesting more than $1,000,000 in direct costs. At the same time, the listed award ceiling reflects $1,000,000, underscoring that most awards may cluster at or below that level, with a dedicated carve-out to accommodate select high-merit projects that require larger direct-cost budgets.
Eligibility was broad and inclusive, spanning many kinds of applicant organizations. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status other than institutions of higher education), for-profit organizations (including small businesses and other for-profits), and a wide variety of government entities such as state governments, county governments, city or township governments, special district governments, and independent school districts. The opportunity also included public housing authorities/Indian housing authorities, Native American tribal organizations and tribal governments (including federally recognized tribes and other tribal entities), and regional organizations. NIH also specified additional eligible groups, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations. Federal government agencies were listed as eligible, as were U.S. territories or possessions. Notably, the eligibility list also included non-domestic (non-U.S.) entities, meaning foreign organizations could apply, which is not always the case across NIH opportunities.
Administratively, the opportunity was posted on August 4, 2010, with an original and current closing date of October 27, 2010, and it was later archived on November 27, 2010. It carried the Health funding activity category and referenced CFDA 93.310 (Trans-NIH Research Support). There was no cost-sharing or matching requirement, which means applicants were not required to contribute non-federal funds as a condition of award. For applicants seeking the full official announcement and detailed requirements, NIH provided an Additional Information link through the NIH Grants Guide, and directed technical access or linking issues to the NIH Office of Extramural Research (OER) webmaster contact.
FAQs: NIH Common Fund Transformative Research Projects Program (R01) - RFA-RM-10-010
What is this funding opportunity?
This is the NIH Common Fund Transformative Research Projects Program using the NIH Research Project Grant (R01) mechanism, announced under Funding Opportunity Number RFA-RM-10-010. It is a discretionary NIH grant competition intended to support research ideas that are bold, unconventional, and potentially field-shaping.
What is the main goal of the Transformative Research Projects Program?
The central goal is to fund projects that are genuinely transformative rather than incremental. NIH is looking for exceptionally innovative, high-risk, and original approaches that could create entirely new scientific paradigms or seriously challenge prevailing assumptions.
What kinds of projects are likely to be competitive under this announcement?
Competitive projects are those that make a clear case for paradigm-shifting potential and major payoff if successful. The proposed work should be more than an improvement on existing approaches and should credibly aim at a major, field-shaping advance.
Does the program favor incremental research improvements?
No. The emphasis is explicitly on ideas that are not just incremental improvements on existing work, but truly transformative efforts that could change how a field thinks or operates.
How broad should the expected impact be?
NIH expects proposed projects, if successful, to have broad and significant impact across biomedical or behavioral research rather than being narrowly specialized.
What grant mechanism is used for this opportunity?
This opportunity uses the standard NIH Research Project Grant mechanism (R01). Applicants propose a defined research project with a scientific plan, milestones, and an overall strategy consistent with the R01 format, with the added emphasis on transformation and paradigm-shifting potential.
What is the NIH Common Fund and how does it relate to this program?
The program sits within the NIH Common Fund, which generally supports cross-cutting research efforts intended to accelerate discovery across multiple NIH institutes and scientific areas.
How much funding did NIH plan to commit to this program?
NIH planned to commit a total of $25,000,000 in FY 2011 to support awards made through this announcement.
How many awards were expected to be made?
The exact number of awards was not fixed. It depended on the size, scope, and overall merit of the applications received.
Is there an award budget limit?
The listed award ceiling reflects $1,000,000 in direct costs, indicating that many awards may be at or below that level.
Can applicants request more than $1,000,000 in direct costs?
Yes. The announcement indicated NIH was willing to support larger-than-typical projects. Up to one third of the total program budget could be set aside for applications requesting more than $1,000,000 in direct costs.
Does this opportunity require cost sharing or matching funds?
No. There was no cost-sharing or matching requirement, meaning applicants were not required to contribute non-federal funds as a condition of award.
Who is eligible to apply?
Eligibility was broad and included many types of organizations, including public and private institutions of higher education, nonprofit organizations, for-profit organizations, and numerous government entities. The announcement also included a range of specialized and community-based eligible groups.
Are institutions of higher education eligible?
Yes. Both public and private institutions of higher education were eligible applicants.
Are nonprofit organizations eligible?
Yes. Eligible applicants included nonprofit organizations with 501(c)(3) status and certain nonprofits without 501(c)(3) status (other than institutions of higher education).
Are for-profit organizations eligible?
Yes. For-profit organizations were eligible, including small businesses and other for-profit entities.
Are state, county, and local governments eligible?
Yes. Eligible government applicants included state governments, county governments, city or township governments, special district governments, and independent school districts.
Are tribal governments and tribal organizations eligible?
Yes. Eligible applicants included Native American tribal organizations and tribal governments, including federally recognized tribes and other tribal entities.
Are public housing authorities or Indian housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities were included in the eligibility list.
Are regional organizations eligible?
Yes. Regional organizations were listed as eligible applicants.
Are minority-serving institutions specifically included as eligible applicants?
Yes. The eligibility list specifically included Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations were included as eligible applicants.
Are federal government agencies eligible to apply?
Yes. Federal government agencies were listed as eligible.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions were included in the eligibility list.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility list included non-domestic (non-U.S.) entities, meaning foreign organizations could apply.
What is the funding activity category for this opportunity?
The funding activity category was Health.
What CFDA number is associated with this opportunity?
The opportunity referenced CFDA 93.310 (Trans-NIH Research Support).
When was this opportunity posted?
The opportunity was posted on August 4, 2010.
What was the application closing date?
The original and current closing date listed for the announcement was October 27, 2010.
Is this funding opportunity still active?
No. It was archived on November 27, 2010.
Where can applicants find the official announcement and full requirements?
NIH provided an Additional Information link through the NIH Grants Guide for the full official announcement and detailed requirements.
Who should be contacted for technical access or linking issues related to the announcement?
NIH directed technical access or linking issues to the NIH Office of Extramural Research (OER) webmaster contact.
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