Opportunity Information: Apply for RFA RM 11 006
Apply for RFA RM 11 006
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH Directors Transformative Research Awards (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Sep 21, 2011 and posted on Sep 21, 2011.
- Applicants must submit their applications by Jan 12, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $25,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Small businesses State governments Native American tribal governments (Federally recognized) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Public and State controlled institutions of higher education County governments City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH Directors Transformative Research Awards (R01) funding opportunity (RFA-RM-11-006) is a discretionary NIH grant program designed to sit alongside, not replace, NIHs standard investigator-initiated research mechanisms. Its purpose is to back research that is genuinely high-risk and high-reward: projects that are groundbreaking, exceptionally innovative, original, or unconventional, and that could realistically reshape thinking in a field or even create entirely new scientific paradigms. A key feature of this program is that applicants are not expected to have extensive preliminary data. Instead, the emphasis is on the boldness of the idea, the strength and logic of the proposed approach, and the likelihood that success would produce a major, broadly relevant impact across biomedical or behavioral research rather than only incremental progress in a narrow niche.
This opportunity uses the R01 activity code and is categorized under health-related funding, with CFDA number 93.310 (Trans-NIH Research Support). The estimated total funding available for the opportunity is $25,000,000, and there is no cost-sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of receiving an award. The program is run by the National Institutes of Health as a trans-NIH initiative, reflecting that proposals can span a wide range of scientific areas so long as they align with the overarching goal of transformative impact.
Eligibility is notably broad and inclusive. Applicants can include many types of U.S.-based organizations such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special districts), as well as independent school districts and public housing or Indian housing authorities. The announcement also explicitly includes a range of specialized or mission-focused institutions and community-based entities, such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. International participation is allowed as well: non-U.S. (foreign) institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined under NIH policy) are permitted, which opens the door for globally distributed teams where that structure is scientifically justified.
From an administrative standpoint, the opportunity was posted and created on September 21, 2011, with an original and current application closing date of January 12, 2012, and an archive date of February 12, 2012. The full announcement was made available through the NIH grants guide at the link provided in the notice. For access issues or technical problems connecting to the announcement, the listed point of contact is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV), reflecting that support for this posting is handled through NIHs central extramural infrastructure.
Overall, this R01 opportunity targets investigators who want to pursue ideas that may be too early, too unconventional, or too paradigm-shifting for traditional review pathways that often depend heavily on preliminary data. The core expectation is not that the project is safe, but that it is plausible, well-reasoned, and positioned such that, if it works, it would significantly move a broad area of biomedical or behavioral science forward.
FAQs: NIH Director's Transformative Research Awards (R01) - RFA-RM-11-006
What is the NIH Director's Transformative Research Awards (R01) program?
It is a discretionary NIH grant program that uses the R01 activity code and is designed to support research that is genuinely high-risk and high-reward. The program is intended to sit alongside, not replace, NIH's standard investigator-initiated research mechanisms.
What is the main goal of this funding opportunity?
The goal is to back projects that are groundbreaking, exceptionally innovative, original, or unconventional, with the potential to reshape thinking in a field or even create entirely new scientific paradigms. The emphasis is on transformative impact rather than incremental advances.
What kinds of projects are a good fit for this opportunity?
Projects that are bold and plausibly positioned to produce a major, broadly relevant impact across biomedical or behavioral research. The opportunity is especially aimed at ideas that may be too early, too unconventional, or too paradigm-shifting for traditional review pathways.
Is preliminary data required to apply?
No. A key feature of this program is that applicants are not expected to have extensive preliminary data. Instead, reviewers emphasize the boldness of the idea, the strength and logic of the proposed approach, and the potential magnitude of impact if successful.
How does this program differ from standard NIH investigator-initiated mechanisms?
This program is intentionally designed for high-risk, high-reward research and is not meant to replace standard mechanisms. It specifically recognizes that transformative ideas may not come with extensive preliminary data and may not fit conventional expectations for lower-risk, incremental proposals.
What activity code does this opportunity use?
The opportunity uses the R01 activity code.
What is the CFDA number for this opportunity?
The CFDA number is 93.310 (Trans-NIH Research Support).
What is the estimated total funding available?
The estimated total funding available is $25,000,000.
Is cost-sharing or matching required?
No. There is no cost-sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of receiving an award.
Which NIH office or structure runs this program?
The program is run by the National Institutes of Health as a trans-NIH initiative. This reflects that proposals can span a wide range of scientific areas as long as they align with the overarching goal of transformative impact.
What scientific areas are eligible under this trans-NIH initiative?
The opportunity can support a wide range of scientific areas, provided the proposed work aligns with the program's focus on transformative impact across biomedical or behavioral research.
Who is eligible to apply?
Eligibility is broad. Applicants may include many types of U.S.-based organizations, including public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and multiple levels of government.
Are state and local government entities eligible?
Yes. Eligible applicants include state governments, county governments, city/township governments, special district governments, independent school districts, and public housing authorities or Indian housing authorities.
Are nonprofits eligible, including organizations without 501(c)(3) status?
Yes. Nonprofits are eligible, including 501(c)(3) organizations and certain non-501(c)(3) nonprofit entities.
Are for-profit organizations eligible?
Yes. For-profit organizations are eligible, including small businesses and other for-profit entities.
Are minority-serving institutions specifically included?
Yes. The announcement explicitly includes historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included among eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly included among eligible applicants.
Can eligible federal agencies apply?
Yes. The announcement indicates that eligible federal agencies are included.
Is international participation allowed?
Yes. International participation is allowed. Non-U.S. (foreign) institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined under NIH policy) are permitted.
Can a U.S. organization include a non-U.S. component in the application?
Yes. Non-U.S. components of U.S. organizations are eligible, and foreign components are permitted when consistent with NIH policy and scientifically justified.
When was this funding opportunity posted?
It was posted and created on September 21, 2011.
What was the application closing date?
The original and current application closing date listed is January 12, 2012.
When was this opportunity archived?
The archive date is February 12, 2012.
Where can applicants find the full announcement?
The full announcement was made available through the NIH grants guide at the link provided in the notice.
Who should be contacted for access issues or technical problems related to the posting?
For access issues or technical problems connecting to the announcement, the listed point of contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the central review emphasis described for this program?
The emphasis is on the boldness of the idea, the strength and logic of the proposed approach, and the likelihood that success would produce a major, broadly relevant impact across biomedical or behavioral research, rather than incremental progress in a narrow niche.
Does the program prioritize safe, low-risk projects?
No. The core expectation is not that the project is safe, but that it is plausible, well-reasoned, and positioned such that, if it works, it would significantly move a broad area of biomedical or behavioral science forward.
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