Opportunity Information: Apply for RFA RM 16 007
Apply for RFA RM 16 007
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "NIH Director's Transformative Research Awards (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310,.
- This funding opportunity was created on Apr 01, 2016 and posted on Apr 01, 2016.
- Applicants must submit their applications by Oct 07, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The NIH Director's Transformative Research Awards (R01), announced under Funding Opportunity Number RFA-RM-16-007 by HHS-NIH (NIH11), is a discretionary grant program in the health funding category (CFDA 93.310) designed to push beyond the usual boundaries of investigator-initiated research. Its central purpose is to fund research that is intentionally high-risk and high-reward: proposals are expected to be bold, unconventional, and unusually innovative, with the potential to reshape how a major biomedical or behavioral problem is understood or addressed. Rather than emphasizing incremental advances, the program targets ideas that could create entirely new scientific paradigms, open up fundamentally new directions for research, establish dramatically improved clinical approaches, or produce transformative technologies that change what is possible in research or care.
A defining feature of this opportunity is that little or no preliminary data are expected, which signals that NIH is explicitly making room for proposals that might be too early, too speculative, or too nontraditional to fare well in standard review environments. Applicants are still expected to make a compelling case for feasibility and potential payoff, but the emphasis is on the magnitude and originality of the concept and the clarity of the argument that, if successful, the work would have major impact across a broad area of biomedical or behavioral research. In other words, the project needs to aim for a step-change, not a modest improvement, and it should be framed in a way that highlights how it could influence more than a narrow niche.
The award uses the R01 funding instrument, meaning it is structured as a research project grant and can support an individual scientist or a group of scientists working together. Eligibility is broad and spans many common U.S. research and public service entities, including state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those specific nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities as further clarified in the opportunity's additional eligibility information. This wide eligibility reflects NIH's intent to attract transformative ideas from many sectors, not only traditional academic settings.
Key administrative details from the posted record include an original and current closing date of October 7, 2016, with the opportunity created and posted on April 1, 2016. While the listing does not provide an award ceiling or expected number of awards in the provided fields, the program description makes clear that selection is driven by the potential for exceptionally high impact and transformative outcomes rather than by conventional expectations like extensive preliminary evidence. Overall, this funding opportunity is best suited for applicants with daring, well-articulated research visions that challenge prevailing assumptions and can credibly argue that success would produce major, field-shifting advances in biomedical or behavioral science.
FAQs: NIH Director's Transformative Research Awards (R01) - RFA-RM-16-007
What is this funding opportunity?
This opportunity is the NIH Director's Transformative Research Awards (R01), offered by HHS-NIH (NIH11) under Funding Opportunity Number RFA-RM-16-007. It is a discretionary government grant program in the health funding category (CFDA 93.310).
What is the main goal of the Transformative Research Awards program?
The central goal is to support research that intentionally pushes beyond the usual boundaries of investigator-initiated research. The program is designed for high-risk, high-reward projects that are bold, unconventional, and unusually innovative, with the potential to reshape how a major biomedical or behavioral problem is understood or addressed.
What kinds of projects is NIH looking for under this program?
The program targets ideas that could create entirely new scientific paradigms, open fundamentally new directions for research, establish dramatically improved clinical approaches, or produce transformative technologies that change what is possible in research or care. The emphasis is on step-change advances rather than incremental progress.
What does "high-risk, high-reward" mean in the context of this opportunity?
In this program, "high-risk, high-reward" means NIH is explicitly making room for proposals that may be early, speculative, or nontraditional, and that might not perform well in standard review environments. The payoff is expected to be potentially large and field-shifting if the work succeeds.
Is preliminary data required to apply?
Little or no preliminary data are expected for this opportunity. Applicants still need to make a compelling case for feasibility and potential payoff, but the program signals that extensive preliminary evidence is not a central expectation.
If preliminary data are not expected, what should applicants emphasize instead?
Applicants should emphasize the magnitude and originality of the concept, along with a clear, credible argument that success would have major impact across a broad area of biomedical or behavioral research. The proposal should be framed to show how it could influence more than a narrow niche.
What funding mechanism does this opportunity use?
The award uses the R01 funding instrument, meaning it is structured as a research project grant.
Can the award support a team of investigators, or only an individual PI?
It can support an individual scientist or a group of scientists working together, consistent with an R01 research project structure.
Who is eligible to apply?
Eligibility is broad and includes many U.S. research and public service entities, such as state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions within those specific nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities as further clarified in the opportunity's additional eligibility information.
Is this opportunity limited to universities and academic medical centers?
No. The eligibility list is intentionally broad and includes government entities, nonprofits, for-profits, small businesses, tribal governments and organizations, and other eligible organizations, reflecting NIH's intent to attract transformative ideas from many sectors.
What research areas does this opportunity cover?
The description focuses on major biomedical or behavioral problems. The key requirement is that the proposed work is transformative in its potential impact on biomedical or behavioral science, rather than being limited to a narrow topic area.
What makes a proposal a good fit for this specific program?
A good fit is a daring, well-articulated research vision that challenges prevailing assumptions and credibly argues that success would produce major, field-shifting advances, such as new paradigms, dramatically improved clinical approaches, or transformative technologies.
Does the listing provide an award ceiling or the expected number of awards?
No. In the provided record fields, the listing does not state an award ceiling or the expected number of awards.
What are the key dates listed for this opportunity?
The opportunity was created and posted on April 1, 2016. The original closing date and the current closing date are both listed as October 7, 2016.
What does the selection emphasis appear to be based on the description?
Selection is driven by the potential for exceptionally high impact and transformative outcomes, rather than conventional expectations such as extensive preliminary evidence or incremental advances.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.310.
Which agency is associated with this funding opportunity?
The opportunity is associated with HHS-NIH (NIH11), and it is described as an NIH Director's award program.
Is this described as a discretionary or mandatory grant program?
It is described as a discretionary grant program.
Browse more opportunities from the same category: Health
Next opportunity: Evaluation of Aberrant Observations and Their Impact on Bioequivalence Assessment (U01)
Previous opportunity: Tectonics
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA RM 16 007
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA RM 16 007) also looked into and applied for these:
| Funding Opportunity |
|---|
| NIH Director's New Innovator Award Program (DP2) Apply for RFA RM 16 004 Funding Number: RFA RM 16 004 Agency: HHS-NIH11 Category: Health Funding Amount: $1,500,000 |
| NIH Pioneer Award Program (DP1) Apply for RFA RM 16 005 Funding Number: RFA RM 16 005 Agency: HHS-NIH11 Category: Health Funding Amount: $700,000 |
| Comprehensive Health Services Delivery (CHSD) Apply for RFA 621 16 000012 Funding Number: RFA 621 16 000012 Agency: USAID-TAN Category: Health Funding Amount: $325,211,110 |
| Capacity building for ecological surveillance of viral hemorrhagic fevers in Sierra Leone Apply for CDC RFA CK16 1605 Funding Number: CDC RFA CK16 1605 Agency: HHS-CDC-NCEZID Category: Health Funding Amount: Case Dependent |
| Program Supplements for Violence Intervention to Enhance Lives (Short Title: VITEL) Apply for TI 16 010 Funding Number: TI 16 010 Agency: HHS-SAMHS Category: Health Funding Amount: $70,000 |
| Indo-U.S. Vaccine Action Program (VAP) Small Research Grant Program (R03) Apply for PA 16 163 Funding Number: PA 16 163 Agency: HHS-NIH11 Category: Health Funding Amount: $100,000 |
| Emerging Infections Programs Apply for CDC RFA CK17 1701 Funding Number: CDC RFA CK17 1701 Agency: HHS-CDC-NCEZID Category: Health Funding Amount: Case Dependent |
| CDC’s Collaboration with Academia to Strengthen Public Health Workforce Capacity Apply for CDC RFA OE12 120105CONT16 Funding Number: CDC RFA OE12 120105CONT16 Agency: HHS-CDC-CSELS Category: Health Funding Amount: Case Dependent |
| Establishment of Resource Centers for Dental, Oral and Craniofacial Tissue Regeneration Consortium (U24) Apply for RFA DE 17 001 Funding Number: RFA DE 17 001 Agency: HHS-NIH11 Category: Health Funding Amount: $2,500,000 |
| American Indians into Nursing Apply for HHS 2016 IHS NU 0001 Funding Number: HHS 2016 IHS NU 0001 Agency: HHS-IHS Category: Health Funding Amount: $400,000 |
| PPHF 2016: Prevention Health and Health Services Block Grants – Behavioral Risk Factor Surveillance System, (BRFSS) – Financed in part by 2016 Prevention and Public Health Funds Apply for CDC RFA DP15 151302CONTPPHF16 Funding Number: CDC RFA DP15 151302CONTPPHF16 Agency: HHS-CDC-NCCDPHP Category: Health Funding Amount: Case Dependent |
| Training and Technical Assistance for Health Department Demonstration Projects for Comprehensive Prevention, Care, Behavioral Health, and Social Services for Men Who Have Sex with Men of Color At Risk for and Living with HIV Infection Apply for CDC RFA PS15 151002CONT16 Funding Number: CDC RFA PS15 151002CONT16 Agency: HHS-CDC-NCHHSTP Category: Health Funding Amount: Case Dependent |
| “Extension of the World Trade Center Health Registry (50)” Apply for RFA OH 16 001 Funding Number: RFA OH 16 001 Agency: HHS-CDC-HHSCDCERA Category: Health Funding Amount: Case Dependent |
| Strengthening sustainable public health capacity in the Eastern Mediterranean Region for polio eradication and routine immunization activities Apply for CDC RFA GH16 160102CONT16 Funding Number: CDC RFA GH16 160102CONT16 Agency: HHS-CDC Category: Health Funding Amount: Case Dependent |
| Building Public Health Capacity for Drought Response Apply for CDC RFA EH16 1603 Funding Number: CDC RFA EH16 1603 Agency: HHS-CDC-NCEH Category: Health Funding Amount: $150,000 |
| NEI Research Grant for Vision Related Secondary Data Analysis (R21) Apply for PAR 16 168 Funding Number: PAR 16 168 Agency: HHS-NIH11 Category: Health Funding Amount: $200,000 |
| Educating State-level Stakeholders on Strategies to Address Winnable Battles in Public Health Apply for CDC RFA SO15 150102CONT16 Funding Number: CDC RFA SO15 150102CONT16 Agency: HHS-CDC Category: Health Funding Amount: Case Dependent |
| Identification of Small Molecules for Sustained-Release Anti-HIV Products (R01) Apply for RFA AI 16 024 Funding Number: RFA AI 16 024 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Advancing HIV Therapeutic Vaccine Science (U01) Apply for RFA AI 16 019 Funding Number: RFA AI 16 019 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Human Tissue Models for Infectious Diseases (U19) Apply for RFA AI 16 022 Funding Number: RFA AI 16 022 Agency: HHS-NIH11 Category: Health Funding Amount: $1,000,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA RM 16 007", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.