Opportunity Information: Apply for PA 13 303

  • The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "NIH Exploratory/Developmental Research Grant Program (Parent R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.172 Human Genome Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.361 Nursing Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research 93.879 Medical Library Assistance.
  • This funding opportunity was created on Aug 2, 2013 and posted on Aug 2, 2013.
  • Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) City or township governments For profit organizations other than small businesses Public and State controlled institutions of higher education Private institutions of higher education Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) County governments State governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The NIH Exploratory/Developmental Research Grant Program (Parent R21) is a discretionary NIH grant opportunity designed to help researchers launch new lines of inquiry and test early-stage ideas that are still being shaped. It specifically targets exploratory and developmental projects, meaning the work is expected to be at a conceptual or proof-of-concept phase rather than a fully mature research program. A central purpose of the R21 mechanism is to encourage research that may be higher risk than typical proposals, but that has the potential to produce high-impact results, such as a breakthrough in a scientific area or the creation of novel tools and approaches. In practical terms, NIH uses the Parent R21 to give investigators room to try innovative concepts, build preliminary data, and develop new techniques, agents, methodologies, models, or applications that could significantly influence biomedical, behavioral, or clinical research fields.

The funding opportunity number for this announcement is PA-13-303, and it was posted and created on August 2, 2013. The original and current closing date listed is September 7, 2016, with an archive date of October 8, 2016, indicating the announcement is no longer active in its posted form and has been archived. The award ceiling is listed as $200,000, reflecting the program’s emphasis on supporting smaller, early-stage projects rather than large-scale, long-duration studies. The opportunity does not require cost sharing or matching, which lowers the barrier to applying for institutions that may not have discretionary funds available to contribute to the project budget.

This Parent R21 announcement spans a wide range of NIH-related program areas and catalog (CFDA) listings, covering major domains of health and research. The CFDA numbers attached to the opportunity include areas such as environmental health (93.113), oral diseases and disorders (93.121), human genome research (93.172), deafness and communication disorders (93.173), complementary and integrative health (93.213), mental health (93.242), alcohol research (93.273), drug abuse and addiction research (93.279), technological innovations to improve human health (93.286), nursing research (93.361), arthritis and musculoskeletal and skin diseases (93.846), neurosciences and neurological disorders (93.853), allergy and infectious diseases (93.855), microbiology and infectious diseases (93.856), child health and human development (93.865), aging research (93.866), vision research (93.867), and medical library assistance (93.879). Taken together, these listings signal that the Parent R21 is broadly applicable across many NIH institutes and mission areas, and that it can support a wide variety of scientific topics so long as they align with the priorities of the relevant NIH components.

Eligibility is intentionally broad and includes many organization types across the public, private, nonprofit, educational, and governmental sectors. Eligible applicants include federally recognized Native American tribal governments and other tribal organizations, state and local governments (including county governments, city or township governments, special district governments, and independent school districts), public and state-controlled institutions of higher education, private institutions of higher education, public housing authorities/Indian housing authorities, and a range of nonprofit organizations including both 501(c)(3) nonprofits and certain nonprofits without 501(c)(3) status (other than higher education institutions). For-profit entities are also eligible, including small businesses and other for-profit organizations that are not small businesses. The eligibility language also explicitly recognizes additional categories such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies.

Notably, the announcement allows participation by non-U.S. entities and components. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are eligible to apply, and non-domestic components of U.S. organizations may also apply. In addition, foreign components (as defined by the NIH Grants Policy Statement) are allowed, which is important for projects that require international collaboration, access to unique populations or resources, or specialized facilities located outside the United States.

The sponsoring agency is the National Institutes of Health, and the official announcement link is provided through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-13-303.html. For technical issues accessing or linking to the full announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

FAQs: NIH Exploratory/Developmental Research Grant Program (Parent R21) - PA-13-303

What is the NIH Parent R21 program?

The NIH Exploratory/Developmental Research Grant Program (Parent R21) is a discretionary NIH grant opportunity intended to help researchers launch new lines of inquiry and test early-stage ideas. It is designed for exploratory and developmental projects that are still being shaped, typically at the conceptual or proof-of-concept stage rather than as a fully mature research program.

What kinds of projects is the Parent R21 meant to support?

The Parent R21 is meant to support exploratory and developmental research, including work focused on trying innovative concepts, building preliminary data, and developing new techniques, agents, methodologies, models, or applications. The overall aim is to enable early work that could significantly influence biomedical, behavioral, or clinical research fields.

Is the R21 mechanism intended for high-risk research?

Yes. A central purpose of the R21 mechanism is to encourage research that may be higher risk than typical proposals, as long as it has the potential to produce high-impact results (for example, a breakthrough in a scientific area or the creation of novel tools and approaches).

What is the funding opportunity number for this announcement?

The funding opportunity number is PA-13-303.

When was this funding opportunity posted?

This announcement was posted and created on August 2, 2013.

What is the closing date for this opportunity?

The listed closing date is September 7, 2016.

Is this announcement still active?

No. The announcement shows an archive date of October 8, 2016, which indicates it is no longer active in its posted form and has been archived.

What is the award ceiling for this opportunity?

The award ceiling is listed as $200,000, reflecting the program's emphasis on supporting smaller, early-stage projects rather than large-scale, long-duration studies.

Does this opportunity require cost sharing or matching funds?

No. The opportunity does not require cost sharing or matching, which can reduce the financial barrier to applying for organizations that do not have discretionary funds available to contribute to the project budget.

Which agency sponsors this opportunity?

The sponsoring agency is the National Institutes of Health (NIH).

How broad is the scientific scope of the Parent R21?

Based on the CFDA listings included with the opportunity, the Parent R21 spans many NIH mission areas and can support a wide variety of scientific topics, provided the work aligns with the priorities of the relevant NIH components.

Which CFDA program areas are associated with this Parent R21 announcement?

The CFDA numbers listed for this opportunity include: environmental health (93.113), oral diseases and disorders (93.121), human genome research (93.172), deafness and communication disorders (93.173), complementary and integrative health (93.213), mental health (93.242), alcohol research (93.273), drug abuse and addiction research (93.279), technological innovations to improve human health (93.286), nursing research (93.361), arthritis and musculoskeletal and skin diseases (93.846), neurosciences and neurological disorders (93.853), allergy and infectious diseases (93.855), microbiology and infectious diseases (93.856), child health and human development (93.865), aging research (93.866), vision research (93.867), and medical library assistance (93.879).

Who is eligible to apply?

Eligibility is broad and includes many organization types across public, private, nonprofit, educational, and governmental sectors. Eligible applicants include federally recognized Native American tribal governments and other tribal organizations; state and local governments (including county governments, city or township governments, special district governments, and independent school districts); public and state-controlled institutions of higher education; private institutions of higher education; public housing authorities/Indian housing authorities; nonprofit organizations (including 501(c)(3) nonprofits and certain nonprofits without 501(c)(3) status, other than higher education institutions); and for-profit entities (including small businesses and other for-profit organizations that are not small businesses). Eligible federal agencies are also included.

Are specific institution types explicitly recognized as eligible?

Yes. The eligibility language explicitly recognizes categories such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also recognizes faith-based or community-based organizations.

Can for-profit organizations apply?

Yes. For-profit entities are eligible, including small businesses and other for-profit organizations that are not small businesses.

Can nonprofits apply even if they do not have 501(c)(3) status?

Yes. The eligibility language includes certain nonprofits without 501(c)(3) status (other than higher education institutions).

Are non-U.S. (foreign) organizations eligible to apply?

Yes. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are eligible to apply.

Can a U.S. organization apply with a non-U.S. component?

Yes. Non-domestic components of U.S. organizations may also apply.

Are foreign components allowed on projects under this announcement?

Yes. Foreign components (as defined by the NIH Grants Policy Statement) are allowed, which can be important for projects involving international collaboration, access to unique populations or resources, or specialized facilities located outside the United States.

Where can I find the official announcement?

The official announcement is available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-13-303.html.

Who should be contacted for technical issues accessing the announcement link?

For technical issues accessing or linking to the full announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

What is the main practical benefit of the Parent R21 mechanism for investigators?

In practical terms, NIH uses the Parent R21 to give investigators room to try innovative concepts, generate or strengthen preliminary data, and develop early tools and approaches that could later support more fully developed research efforts.

Is this opportunity intended to fund large, long-duration studies?

No. The program description and the $200,000 award ceiling emphasize smaller, early-stage projects rather than large-scale, long-duration studies.

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