Opportunity Information: Apply for PA 14 042

  • The National Institutes of Health in the education environment food and nutrition health income security and social services sector is offering a public funding opportunity titled "NIH Pathway to Independence Award (Parent K99/R00)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.172 Human Genome Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.233 National Center on Sleep Disorders Research 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.351 Research Infrastructure Programs 93.361 Nursing Research 93.398 Cancer Research Manpower 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research 93.879 Medical Library Assistance.
  • This funding opportunity was created on Jan 8, 2015 and posted on Dec 19, 2013.
  • Applicants must submit their applications by Jan 8, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: County governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Native American tribal governments (Federally recognized) City or township governments For profit organizations other than small businesses Private institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The NIH Pathway to Independence Award (Parent K99/R00), funding opportunity number PA-14-042, is a discretionary NIH grant program designed to help outstanding postdoctoral researchers move more quickly and successfully from mentored postdoctoral training into independent, tenure-track (or equivalent) faculty positions. The central goal is workforce development: NIH is aiming to build and sustain a strong pipeline of talented, NIH-supported investigators by smoothing the transition point where many research careers can stall. The award is structured specifically to support that transition in two phases, pairing mentored development with a subsequent period of independent research support so that recipients are positioned to compete effectively as new principal investigators.

Programmatically, the K99/R00 mechanism combines a mentored career development component (the K99 phase) with an independent research component (the R00 phase). In practical terms, the K99 phase supports the candidate while they are still in a postdoctoral or equivalent mentored position, focused on completing key training and research milestones that prepare them for independence. The R00 phase then provides NIH research support after the awardee secures an independent faculty position, helping them launch their laboratory or independent research program and generate the results needed to compete for larger, long-term NIH funding. This structure is meant to reduce the lag time between postdoctoral work and independent grant support, and to make the jump to an independent position more achievable for highly promising scientists.

The opportunity is offered by the National Institutes of Health and spans a wide range of NIH mission areas and participating Institutes and Centers, as reflected by the many CFDA listings associated with it. Those areas include, among others, environmental health, oral health, human genome research, communication disorders, complementary and integrative health, sleep disorders, mental health, alcohol research, drug abuse and addiction, biomedical technology innovation, research infrastructure, nursing research, cancer research training and manpower, heart/lung/blood, arthritis and musculoskeletal and skin diseases, diabetes/digestive/kidney diseases, neurological disorders, allergy and infectious diseases, general biomedical research and training, child health and human development, aging, vision research, and medical library assistance. Because different NIH Institutes and Centers can have different priorities and may apply IC-specific requirements or budget guidance, prospective applicants are strongly encouraged to contact relevant NIH program staff and review the posted table of IC-specific information, requirements, and staff contacts referenced in the announcement.

In terms of who can apply as the applicant organization, eligibility is broad across U.S.-based entities and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) organizations that are not institutions of higher education), small businesses, other for-profit organizations (excluding small businesses where specified), state governments, county governments, city or township governments, special district governments, and Native American tribal governments (both federally recognized and other than federally recognized), as well as tribal organizations. The eligibility notes also call out a range of institution types and communities, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander-serving institutions, along with faith-based or community-based organizations and eligible federal agencies. At the same time, non-U.S. (foreign) institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible; however, “foreign components” as defined under the NIH Grants Policy Statement are allowed, which typically means a portion of the project can be conducted abroad under specific NIH rules even though the applicant organization must be eligible and based in the U.S. The opportunity states there is no cost sharing or matching requirement.

Administrative details in the provided source indicate the opportunity was posted on December 19, 2013 (with a creation date listed as January 8, 2015), and it has closing and archival dates reflecting the lifecycle of that particular announcement version (original closing date January 7, 2017; current closing date January 8, 2015; archive date February 8, 2015). The full announcement is linked through NIH at http://grants.nih.gov/grants/guide/pa-files/PA-14-042.html, and NIH’s Office of Extramural Research provides a webmaster contact for access or linking issues (FBOWebmaster@OD.NIH.GOV). For applicants, the most important practical takeaway is that this mechanism is specifically meant for exceptional postdoctoral researchers who are ready to define a clear path to independence, and NIH expects candidates to engage early with the relevant NIH Institute/Center staff to ensure alignment with IC priorities and to understand any IC-specific programmatic or budgetary expectations before applying.

FAQs: NIH Pathway to Independence Award (Parent K99/R00) - PA-14-042

What is the NIH Pathway to Independence Award (Parent K99/R00)?

The NIH Pathway to Independence Award (Parent K99/R00) is a discretionary NIH grant program designed to help outstanding postdoctoral researchers transition more quickly and successfully from mentored postdoctoral training into independent, tenure-track (or equivalent) faculty positions.

What is the main goal of this funding opportunity?

The central goal is workforce development. NIH aims to build and sustain a strong pipeline of talented, NIH-supported investigators by smoothing a major transition point where research careers can stall: moving from postdoctoral training into an independent research position.

How is the K99/R00 award structured?

The mechanism has two linked phases: a mentored career development component (the K99 phase) followed by an independent research component (the R00 phase). Together, they are intended to reduce the lag between postdoctoral work and independent research support.

What does the K99 phase support?

The K99 phase supports the candidate while they remain in a postdoctoral (or equivalent) mentored position. It focuses on completing key training and research milestones that prepare the candidate for independence.

What does the R00 phase support?

The R00 phase provides NIH research support after the awardee secures an independent faculty position. It is intended to help launch an independent research program (such as starting a lab) and generate results needed to compete for larger, long-term NIH funding.

Who is this award intended for?

This mechanism is specifically meant for exceptional postdoctoral researchers who are ready to define a clear, credible path to research independence and to move into an independent, tenure-track (or equivalent) position.

What is the practical career transition this award is designed to support?

It is designed to support the transition from mentored postdoctoral training to an independent faculty role, pairing mentored development with subsequent independent research support so recipients are positioned to compete effectively as new principal investigators.

Which federal agency offers this opportunity?

The opportunity is offered by the National Institutes of Health (NIH).

Does this opportunity cover specific scientific or health areas?

Yes. It spans a wide range of NIH mission areas and participating Institutes and Centers, reflected by the many CFDA listings associated with it. The listed areas include (among others) environmental health, oral health, human genome research, communication disorders, complementary and integrative health, sleep disorders, mental health, alcohol research, drug abuse and addiction, biomedical technology innovation, research infrastructure, nursing research, cancer research training and manpower, heart/lung/blood, arthritis and musculoskeletal and skin diseases, diabetes/digestive/kidney diseases, neurological disorders, allergy and infectious diseases, general biomedical research and training, child health and human development, aging, vision research, and medical library assistance.

Do different NIH Institutes and Centers (ICs) have different requirements for this award?

They can. The opportunity notes that different NIH Institutes and Centers may have different priorities and may apply IC-specific requirements or budget guidance. Applicants are encouraged to review the posted table of IC-specific information, requirements, and staff contacts referenced in the announcement.

Should applicants contact NIH program staff before applying?

Yes. Prospective applicants are strongly encouraged to contact the relevant NIH program staff early to confirm alignment with Institute/Center priorities and to understand any IC-specific programmatic or budgetary expectations.

Who can serve as the applicant organization for this opportunity?

Eligibility is broad across U.S.-based entities. Eligible applicant organizations include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) organizations that are not institutions of higher education), small businesses, other for-profit organizations (excluding small businesses where specified), state governments, county governments, city or township governments, special district governments, Native American tribal governments (federally recognized and other than federally recognized), and tribal organizations.

Are certain institution types or communities specifically noted as eligible?

Yes. The eligibility notes call out a range of institution types and communities, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander-serving institutions. Faith-based or community-based organizations and eligible federal agencies are also noted.

Are non-U.S. (foreign) institutions eligible to apply?

No. Non-U.S. (foreign) institutions are not eligible to apply under this opportunity.

Are non-U.S. components of U.S. organizations eligible?

No. Non-U.S. components of U.S. organizations are not eligible.

Are foreign components allowed at all?

Yes. The opportunity states that “foreign components” (as defined under the NIH Grants Policy Statement) are allowed. This generally means a portion of the project may be conducted abroad under specific NIH rules, while the applicant organization must still be eligible and U.S.-based.

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

What is the funding opportunity number?

The funding opportunity number is PA-14-042.

Where can applicants find the full announcement?

The full announcement is available through NIH at: http://grants.nih.gov/grants/guide/pa-files/PA-14-042.html

When was this opportunity posted?

The provided source indicates it was posted on December 19, 2013, with a creation date listed as January 8, 2015.

What dates are listed for closing and archiving?

The provided source lists multiple lifecycle dates for that announcement version, including an original closing date of January 7, 2017; a current closing date of January 8, 2015; and an archive date of February 8, 2015.

Who should be contacted for access or linking issues related to the NIH announcement page?

NIH’s Office of Extramural Research provides a webmaster contact for access or linking issues: FBOWebmaster@OD.NIH.GOV

What is the key takeaway for prospective applicants?

The main practical takeaway is that this mechanism is meant for highly promising postdoctoral researchers preparing for independence, and NIH expects candidates to engage early with the relevant NIH Institute/Center staff and to review IC-specific information to ensure fit with priorities and expectations.

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Funding Number: RFA HG 14 008
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PHS 2014 02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR R41/R42 Apply for PA 14 072

Funding Number: PA 14 072
Agency: National Institutes of Health
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PHS 2014 02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR R43/R44) Apply for PA 14 071

Funding Number: PA 14 071
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
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Change of Grantee Organization (Type 7 Parent) Apply for PA 14 078

Funding Number: PA 14 078
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
Successor in Interest (Type 6 Parent) Apply for PA 14 079

Funding Number: PA 14 079
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp) Apply for PA 14 077

Funding Number: PA 14 077
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) Apply for PA 14 147

Funding Number: PA 14 147
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
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Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health Related Research (Parent F31 Diversity) Apply for PA 14 148

Funding Number: PA 14 148
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) Apply for PA 14 149

Funding Number: PA 14 149
Agency: National Institutes of Health
Category: Education Environment Food and Nutrition Health Income Security and Social Services
Funding Amount: Case Dependent
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual Doctoral Degree Fellowship (Parent F30) Apply for PA 14 150

Funding Number: PA 14 150
Agency: National Institutes of Health
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