NIH PEPFAR Collaboration on Implementation Science for HIV Towards an AIDS free Generation (R21) | Apply Online

Opportunity Summary:

The NIH PEPFAR Collaboration on Implementation Science for HIV Towards an AIDS free Generation (R21) funding opportunity (RFA-AI-15-021) is a discretionary NIH grant program created in partnership with the Office of the Global AIDS Coordinator (OGAC) under PEPFAR. Its central purpose is to support implementation science research that helps move proven HIV interventions from controlled or pilot settings into real-world health systems across Africa. The emphasis is not on discovering brand-new biomedical tools, but on figuring out how to deliver, adapt, integrate, and scale interventions that are already known to work, so they achieve stronger prevention outcomes, better linkage to care, improved retention, and more effective treatment at population level. In practical terms, the program is meant to generate evidence about what implementation strategies, service delivery models, and health system approaches lead to faster, more reliable uptake of effective HIV programs in African contexts, and what barriers need to be addressed to reach an AIDS-free generation.

This opportunity uses the NIH R21 mechanism, which is typically intended for exploratory or developmental projects that can produce early, actionable findings, generate implementation-relevant data, or establish proof-of-concept for approaches that can later be tested at larger scale. The announcement indicates an award ceiling of $200,000, with an estimated total funding amount of $1,000,000 across awards. There is no cost sharing or matching requirement. The announcement was posted on April 24, 2015, with a single application due date of July 28, 2015, and an archive date of August 28, 2015, meaning it is no longer open but provides a clear snapshot of what NIH and OGAC sought to fund at that time.

The research scope is anchored in implementation science for HIV prevention, care, and treatment in Africa. That includes studying how to improve delivery and scale-up of efficacious interventions, which could involve examining health service workflows, workforce and task-shifting models, clinic and community delivery platforms, adherence and retention supports, differentiated care approaches, monitoring and evaluation systems, supply chain or laboratory system linkages, data-driven quality improvement, and strategies for reaching priority or underserved populations. Because the collaboration includes OGAC, the work is implicitly aligned with PEPFAR program priorities and the realities of public-sector and partner-supported HIV programs, where decisions often depend on feasibility, cost, sustainability, equity, and the ability to operate at national or subnational scale.

Eligible applicants are broad and include many types of U.S. and non-U.S. organizations. Eligible entities listed include state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Academic eligibility covers public and state-controlled institutions of higher education as well as private institutions of higher education, and the nonprofit landscape includes both 501(c)(3) and non-501(c)(3) organizations (other than institutions of higher education). The solicitation also allows for-profit organizations (including small businesses and other for-profits). In addition, the opportunity explicitly extends eligibility to a wide set of mission- and community-focused institutions and organizations such as faith-based or community-based organizations, historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander serving institutions (AANAPISIs). Importantly for global HIV implementation research, the announcement includes non-domestic (non-U.S.) entities (foreign organizations), regional organizations, and U.S. territories or possessions, which supports direct engagement and leadership from organizations working in African settings.

From an administrative standpoint, the program sits within NIH and spans multiple relevant NIH CFDA program areas, reflecting the cross-cutting nature of HIV implementation science. The CFDA numbers listed include 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), along with related areas such as mental health research (93.242), drug abuse and addiction research programs (93.279), nursing research (93.361), and child health and human development extramural research (93.865). This range signals that the funded work could intersect with behavioral health, substance use, nursing and care delivery, and maternal/child or adolescent health considerations, as long as the core aim remains improving implementation and scale-up of HIV interventions.

The full announcement was made available through an NIH grants guide link (http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-15-021.html). For technical issues accessing the announcement, NIH provided contact through the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

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