Opportunity Information: Apply for RFA RM 15 005
Apply for RFA RM 15 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH Transformative Research Awards (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Jun 1, 2015 and posted on Jun 1, 2015.
- Applicants must submit their applications by Oct 9, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $15,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Private institutions of higher education County governments Small businesses Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public and State controlled institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH Transformative Research Awards (R01) funding opportunity (RFA-RM-15-005) is a discretionary NIH grant program designed to back research that is intentionally high-risk and high-reward. Unlike many traditional NIH investigator-initiated grants that tend to emphasize strong preliminary data and incremental advances, this program is aimed at proposals that are genuinely unconventional or unusually creative, where the central idea has the potential to shift how a field thinks or operates. NIH is explicitly looking for projects that could create new scientific paradigms, open up entirely new lines of biomedical or behavioral research, lead to fundamentally improved clinical approaches, or produce transformative technologies. A key feature of the announcement is that little or no preliminary data are expected, which signals that the program is meant to make room for bold ideas that are not yet well supported by standard datasets but are compelling because of their originality and potential impact.
The core requirement is not simply novelty for noveltys sake, but a clear and credible argument that the work could have major impact in a broad area of biomedical or behavioral research. In practice, this means applicants need to articulate why the idea is paradigm-shifting, what current limitation or assumption it challenges, and how success would meaningfully alter research directions, clinical practice, or technological capabilities beyond a narrow niche. The program supports applications from individual investigators as well as groups of scientists, reflecting NIHs interest in both single-lab breakthroughs and team-based approaches when the problem or innovation demands multiple kinds of expertise.
Administratively, the award uses the R01 grant mechanism under the Health funding activity category, with CFDA number 93.310 (Trans-NIH Research Support). The opportunity does not require cost sharing or matching. NIH estimated total funding for this announcement at $15,000,000. The opportunity was posted on June 1, 2015, with an original and current closing date of October 9, 2015, and an archive date of November 9, 2015, indicating it was a time-limited solicitation.
Eligibility is broad and includes many types of U.S.-based entities across the public, private, nonprofit, and for-profit spectrum. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (other than institutions of higher education), small businesses, and other for-profit organizations (in addition to small businesses). Government entities are also eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities including Indian housing authorities. Tribal eligibility includes federally recognized Native American tribal governments as well as tribal organizations that are not federally recognized. The announcement also notes eligibility for a range of mission-focused or designated institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, regional organizations, and eligible federal agencies. U.S. territories or possessions are included as eligible applicants.
At the same time, the notice draws clear boundaries around foreign participation. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components, as NIH defines them in the NIH Grants Policy Statement, are allowed, which typically means a U.S. applicant organization may include certain foreign elements in the proposed research when justified and consistent with NIH policy.
For applicants seeking the official announcement text and application instructions, NIH provided an additional information link to the NIH Guide for Grants and Contracts page for RFA-RM-15-005. For access or technical issues with the announcement, NIH directed inquiries to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: NIH Transformative Research Awards (R01) - RFA-RM-15-005
What is the NIH Transformative Research Awards (R01) program?
The NIH Transformative Research Awards (R01) program (funding opportunity RFA-RM-15-005) is a discretionary NIH grant program intended to support research that is deliberately high-risk and high-reward, with the goal of enabling unusually creative, unconventional ideas that could transform a broad area of biomedical or behavioral research.
What makes this opportunity different from a traditional NIH R01?
Unlike many traditional investigator-initiated NIH grants that often emphasize strong preliminary data and incremental progress, this program is designed for proposals that are genuinely unconventional and potentially paradigm-shifting. A notable feature is that little or no preliminary data are expected, signaling NIH's intent to make room for bold ideas that may not yet be supported by standard datasets.
What kinds of projects is NIH trying to fund through this award?
NIH is looking for projects with the potential to create new scientific paradigms, open entirely new lines of biomedical or behavioral research, lead to fundamentally improved clinical approaches, or produce transformative technologies.
Is novelty alone enough to be competitive?
No. The emphasis is not novelty for its own sake. Applicants are expected to make a clear, credible case that the work could have major impact in a broad biomedical or behavioral area, including what limitation or assumption the idea challenges and how success would meaningfully change research directions, clinical practice, or technological capabilities beyond a narrow niche.
Are preliminary data required?
No. The announcement indicates that little or no preliminary data are expected, reflecting the program's focus on high-risk, high-reward ideas.
Who can apply: individual investigators or teams?
Both are supported. The opportunity supports applications from individual investigators as well as groups of scientists, reflecting NIH interest in single-investigator breakthroughs and team-based approaches when multiple areas of expertise are needed.
What grant mechanism does this program use?
This opportunity uses the NIH R01 grant mechanism under the Health funding activity category.
What is the CFDA number for this opportunity?
The CFDA number listed is 93.310 (Trans-NIH Research Support).
Is cost sharing or matching required?
No. The opportunity states that cost sharing or matching is not required.
How much total funding did NIH estimate for this announcement?
NIH estimated total funding for the announcement at $15,000,000.
When was the opportunity posted?
The opportunity was posted on June 1, 2015.
What were the application deadline and related dates?
The original and current closing date listed was October 9, 2015, and the archive date was November 9, 2015, indicating this was a time-limited solicitation.
Is this funding opportunity still open?
Based on the dates provided (closing date October 9, 2015 and archive date November 9, 2015), the solicitation was time-limited and is not indicated as open in the provided information.
What types of U.S. organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based entities across public, private, nonprofit, and for-profit sectors. Examples listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (other than institutions of higher education), small businesses, and other for-profit organizations (in addition to small businesses).
Are government entities eligible applicants?
Yes. Eligible government entities listed include state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities (including Indian housing authorities).
Are tribal governments and tribal organizations eligible?
Yes. The announcement notes eligibility for federally recognized Native American tribal governments and also for tribal organizations that are not federally recognized.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included as eligible applicants.
Are minority-serving and designated institutions eligible?
Yes. The announcement explicitly notes eligibility for mission-focused or designated institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included among the eligible applicant types listed.
Are regional organizations eligible?
Yes. Regional organizations are included among the eligible applicant types listed.
Are federal agencies eligible to apply?
The announcement indicates that eligible federal agencies are included among the eligible applicant types.
Are non-U.S. (foreign) institutions eligible to apply?
No. The notice states that non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply.
Can a U.S. organization apply if it has a non-domestic component?
No. The notice states that non-domestic components of U.S. organizations are not eligible to apply.
Are any foreign elements allowed in the proposed research?
Yes, with limits. While foreign institutions cannot apply, the announcement indicates that foreign components (as NIH defines them in the NIH Grants Policy Statement) are allowed. This generally means a U.S. applicant organization may include certain foreign elements in the proposed research when justified and consistent with NIH policy.
Where can applicants find the official announcement text and instructions?
NIH provided an additional information link to the NIH Guide for Grants and Contracts page for RFA-RM-15-005 for the official announcement text and application instructions.
Who should be contacted for access or technical issues with the announcement?
For access or technical issues, NIH directed inquiries to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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