Opportunity Information: Apply for RFA HD 12 210
Apply for RFA HD 12 210
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "NIH/PEPFAR Collaboration for Advancing Implementation Science in Prevention of Maternal Child HIV Transmission (PMTCT) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research 93.989 International Research and Research Training.
- This funding opportunity was created on Sep 6, 2011 and posted on Sep 6, 2011.
- Applicants must submit their applications by Feb 28, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,350,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal governments (Federally recognized) Private institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Small businesses County governments Independent school districts Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity titled "NIH/PEPFAR Collaboration for Advancing Implementation Science in Prevention of Maternal Child HIV Transmission (PMTCT) (R01)" (Funding Opportunity Number RFA-HD-12-210) is a discretionary NIH research grant that supported implementation science projects focused on improving how proven PMTCT interventions are delivered in real-world settings. Rather than funding basic discovery work or early-stage efficacy trials, the emphasis is on practical research that helps the Presidents Emergency Plan for AIDS Relief (PEPFAR) make service delivery more efficient, more cost effective, and more impactful for preventing HIV transmission from mothers to infants and children. In other words, the goal is to generate evidence about what works in routine programs, how to get proven approaches adopted and sustained at scale, and how to strengthen health systems and service delivery models so that PMTCT outcomes improve.
This opportunity used the NIH R01 mechanism, meaning it was intended for substantial, hypothesis-driven research projects that can produce generalizable knowledge. The activity category sits under Health, Income Security and Social Services, and it is associated with CFDA numbers 93.865 (Child Health and Human Development Extramural Research) and 93.989 (International Research and Research Training), which signals an expectation of strong maternal-child health relevance and a meaningful global health or international research dimension. The opportunity description makes clear that NIH partnered with the Office of the Global AIDS Coordinator, reinforcing that funded projects were expected to be program-relevant for PEPFAR operations and decision-making, not just academically interesting.
A central theme of the announcement is implementation science in PMTCT. That typically means studying barriers and facilitators to delivering evidence-based PMTCT services, comparing alternative delivery strategies, testing approaches to improve uptake and adherence, strengthening linkage and retention across the maternal-infant care cascade, and evaluating models that reduce costs while maintaining or improving outcomes. Projects under this umbrella often examine how interventions perform when integrated into routine antenatal care, labor and delivery services, postnatal follow-up, pediatric care, and community-based platforms, with attention to health workforce constraints, supply chains, data systems, stigma, geography, and other real-world factors that shape whether PMTCT services actually reach families effectively.
From an administrative standpoint, the opportunity was posted on September 6, 2011, with an original and current closing date of February 28, 2012, and it was archived on March 30, 2012. The estimated total funding amount listed was $3,350,000. There was no cost sharing or matching requirement, which generally reduces barriers to applying and allows applicants to focus budgets on the research and implementation components rather than raising non-federal contributions.
Eligibility was broad and included many types of U.S. domestic entities as well as non-U.S. organizations. Eligible applicants included federal recognized tribal governments and other tribal organizations, state and local governments (including counties, cities or townships, special districts, independent school districts, and public housing authorities/Indian housing authorities), public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses. The eligibility section also explicitly referenced a range of institution types often highlighted in federal opportunities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, faith-based and community-based organizations, regional organizations, and U.S. territories or possessions. Importantly for a PEPFAR-aligned PMTCT topic, foreign institutions were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were allowed, signaling that projects could be based in or closely partnered with countries and health systems where PEPFAR operates.
Taken together, this RFA was essentially a targeted NIH-PEPFAR call for rigorous, real-world research that helps translate PMTCT evidence into high-performing programs at scale. The intent was to build a stronger evidence base for how best to organize and deliver PMTCT services in resource-constrained settings, with a clear line of sight to PEPFAR program improvement, greater efficiency, and better maternal and child HIV outcomes. For applicants seeking full details beyond the summary, the announcement provided an official link to the NIH posting (http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-12-210.html) and directed technical access questions to the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: NIH/PEPFAR Collaboration for Advancing Implementation Science in Prevention of Maternal Child HIV Transmission (PMTCT) (R01) - RFA-HD-12-210
What is the title and funding opportunity number for this grant?
The opportunity is titled "NIH/PEPFAR Collaboration for Advancing Implementation Science in Prevention of Maternal Child HIV Transmission (PMTCT) (R01)" and the Funding Opportunity Number is RFA-HD-12-210.
What type of grant mechanism is used?
This opportunity used the NIH R01 mechanism, intended for substantial, hypothesis-driven research projects designed to generate generalizable knowledge.
What is the main purpose of this funding opportunity?
The purpose is to support implementation science research focused on improving how proven PMTCT interventions are delivered in real-world settings, with an emphasis on making PEPFAR service delivery more efficient, more cost effective, and more impactful for preventing HIV transmission from mothers to infants and children.
Is this opportunity focused on basic science or early-stage efficacy trials?
No. The emphasis is not on basic discovery work or early-stage efficacy trials. It prioritizes practical research that studies how evidence-based PMTCT approaches are adopted, implemented, sustained, and scaled in routine programs.
What does "implementation science" mean in the context of PMTCT for this RFA?
In this RFA, implementation science typically includes studying barriers and facilitators to delivering evidence-based PMTCT services, comparing alternative delivery strategies, testing approaches to improve uptake and adherence, strengthening linkage and retention across the maternal-infant care cascade, and evaluating models that reduce costs while maintaining or improving outcomes.
What kinds of real-world service settings are relevant to projects under this opportunity?
Projects may examine how interventions perform when integrated into routine antenatal care, labor and delivery services, postnatal follow-up, pediatric care, and community-based platforms, including consideration of health workforce constraints, supply chains, data systems, stigma, geography, and other real-world factors affecting access and quality.
How is PEPFAR connected to this funding opportunity?
NIH partnered with the Office of the Global AIDS Coordinator, and funded projects were expected to be program-relevant for PEPFAR operations and decision-making, not solely academically oriented.
What outcomes or impact is the RFA aiming to achieve?
The RFA aims to generate evidence about what works in routine PMTCT programs, how proven approaches can be adopted and sustained at scale, and how health systems and service delivery models can be strengthened to improve PMTCT outcomes, with a clear line of sight to PEPFAR program improvement and efficiency.
What is the activity category for this opportunity?
The activity category is listed under Health, Income Security and Social Services.
Which CFDA numbers are associated with this opportunity?
This opportunity is associated with CFDA 93.865 (Child Health and Human Development Extramural Research) and CFDA 93.989 (International Research and Research Training).
What do the listed CFDA numbers suggest about the research scope?
They signal an expectation of strong maternal-child health relevance and a meaningful global health or international research dimension.
When was the opportunity posted?
The opportunity was posted on September 6, 2011.
What was the application closing date?
The original and current closing date was February 28, 2012.
Is the opportunity still open?
No. It was archived on March 30, 2012.
What was the estimated total funding amount?
The estimated total funding amount listed was $3,350,000.
Was cost sharing or matching required?
No. There was no cost sharing or matching requirement.
Who was eligible to apply?
Eligibility was broad and included U.S. domestic entities and non-U.S. organizations. Eligible applicants included tribal governments and tribal organizations; state and local governments (including counties, cities or townships, special districts, independent school districts, and public housing authorities/Indian housing authorities); public and private institutions of higher education; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses.
Were foreign institutions eligible?
Yes. Foreign institutions were eligible to apply.
Were non-U.S. components of U.S. organizations allowed?
Yes. Non-U.S. components of U.S. organizations were eligible.
Were foreign components permitted under NIH policy?
Yes. Foreign components (as defined by NIH policy) were allowed.
Does the eligibility language explicitly include certain institution types?
Yes. The eligibility section explicitly referenced institution types often highlighted in federal opportunities, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, faith-based and community-based organizations, regional organizations, and U.S. territories or possessions.
What kinds of organizations are included under local government eligibility?
The eligibility description includes counties, cities or townships, special districts, independent school districts, and public housing authorities/Indian housing authorities.
Is this a discretionary NIH research grant?
Yes. It is described as a discretionary NIH research grant supporting implementation science projects relevant to PMTCT service delivery.
Where can applicants find the official NIH posting for full details?
The official NIH posting link provided is: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-12-210.html
Who should be contacted for technical access questions related to the NIH posting?
Technical access questions were directed to the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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