Opportunity Information: Apply for PAR 11 293
Apply for PAR 11 293
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NINDS Exploratory/Developmental Projects in Translational Research (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Apr 10, 2012 and posted on Aug 8, 2011.
- Applicants must submit their applications by Jan 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Independent school districts State governments Small businesses Private institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal governments (Federally recognized) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NINDS Exploratory/Developmental Projects in Translational Research (R21) opportunity (Funding Opportunity Number PAR-11-293) is a National Institutes of Health (NIH) discretionary grant program designed to move potential therapies for neurological disorders through early, practical stages of preclinical development. The core intent is to fund focused, translational project work that helps a therapeutic candidate progress toward a clear next step: a follow-on effort that completes the remaining development activities needed to support an FDA submission, either an Investigational New Drug (IND) application for drugs/biologics or an Investigational Device Exemption (IDE) application for devices. In other words, this R21 is meant to de-risk and advance a therapy concept to the point where a later project can credibly finish the package required for regulatory entry into human testing.
The scope is intentionally narrow and centered only on therapy development activities in the preclinical space. Projects should be framed around concrete development tasks that strengthen the therapeutic’s readiness for the regulatory path, rather than open-ended exploration. The announcement is explicit about what it will not support: diagnostics, biomarker development, and rehabilitation strategies are out of scope. It also excludes clinical research, basic research, and studies focused primarily on understanding disease mechanisms. Applicants are expected to propose work that is clearly translational and developmental, emphasizing practical milestones that directly support therapeutic advancement rather than hypothesis-driven basic biology.
From an administrative and funding standpoint, the program uses the NIH R21 mechanism under the Health funding activity category, with CFDA number 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders). The listed award ceiling is $200,000, and there is no cost sharing or matching requirement. Key dates in the archived record include a posted date of August 8, 2011, an original closing date of September 7, 2012, a later closing date of January 7, 2013, and an archive date of February 7, 2013.
Eligibility is broad and spans many organization types, reflecting NIH’s typical openness to a wide research ecosystem. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and private institutions of higher education (including public/state-controlled institutions); nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions where applicable); for-profit organizations (including small businesses and other for-profits); public housing authorities/Indian housing authorities; and a wide range of tribal entities, including federally recognized tribal governments and other tribal organizations. The eligibility list also explicitly includes historically underrepresented or mission-specific institutions and organizations such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, tribally controlled colleges and universities, faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. Foreign (non-U.S.) entities are also included as eligible applicants, indicating that non-domestic organizations may apply when appropriate.
Overall, this FOA is best understood as a targeted bridge between discovery and full-scale preclinical development for neurological therapeutics, supporting early translational steps that create a direct runway to an IND- or IDE-enabling program. For full details and official requirements, the announcement is linked at http://grants.nih.gov/grants/guide/pa-files/PAR-11-293.html, and assistance with access or linking issues is routed through the NIH Office of Extramural Research webmaster contact listed in the notice.
FAQs: NINDS Exploratory/Developmental Projects in Translational Research (R21) - PAR-11-293
What is the NINDS Exploratory/Developmental Projects in Translational Research (R21) opportunity?
It is a National Institutes of Health (NIH) discretionary grant program from the National Institute of Neurological Disorders and Stroke (NINDS) that uses the R21 mechanism to support exploratory/developmental translational research activities for potential therapies targeting neurological disorders.
What is the main purpose of this R21 funding opportunity?
The purpose is to move a potential therapy through early, practical stages of preclinical development so the candidate is positioned for a credible next-step project that can complete the remaining development work needed to support an FDA submission for entry into human testing.
What does "translational" mean in the context of this FOA?
In this FOA, "translational" is narrowly defined around practical, developmental preclinical tasks that directly strengthen a therapeutic candidate's readiness for the regulatory path (for example, work that reduces risk and advances the candidate toward an IND- or IDE-enabling program), rather than open-ended scientific exploration.
What kind of end goal should applicants be working toward?
Projects should be aimed at advancing a therapy concept to the point where a follow-on effort can finish the development package required to support either an Investigational New Drug (IND) application (for drugs/biologics) or an Investigational Device Exemption (IDE) application (for devices).
Is this program focused on preclinical or clinical research?
This program is focused on preclinical therapy development activities. Clinical research is explicitly excluded from the supported scope.
Are basic research projects responsive to this FOA?
No. Basic research and studies focused primarily on understanding disease mechanisms are listed as out of scope. The FOA emphasizes translational and developmental activities tied to therapeutic advancement.
Does this FOA support diagnostics or biomarker development?
No. Diagnostics and biomarker development are explicitly listed as out of scope for this opportunity.
Does this FOA support rehabilitation strategies?
No. Rehabilitation strategies are explicitly excluded from the scope of this funding opportunity.
How should a proposed project be framed to fit the FOA?
Projects should be framed around concrete, focused development tasks and practical milestones that directly support therapeutic advancement and readiness for the regulatory path, rather than broad or open-ended exploratory studies.
What grant mechanism is used for this opportunity?
The program uses the NIH R21 grant mechanism.
What is the funding activity category for this program?
The funding activity category is Health.
What is the CFDA number associated with this program?
The CFDA number is 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
What is the award ceiling listed for this opportunity?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including: state, county, city/township, and special district governments; independent school districts; public and private institutions of higher education (including public/state-controlled institutions); nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions where applicable); for-profit organizations (including small businesses and other for-profits); public housing authorities/Indian housing authorities; tribal governments (federally recognized) and other tribal organizations; eligible federal agencies; regional organizations; and U.S. territories or possessions.
Are mission-specific or historically underrepresented institutions included in eligibility?
Yes. The eligibility list explicitly includes organizations such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and tribally controlled colleges and universities, as well as faith-based or community-based organizations.
Can foreign (non-U.S.) organizations apply?
Yes. Foreign entities are included as eligible applicants, indicating that non-U.S. organizations may apply when appropriate.
What types of therapeutic modalities does the FOA mention?
The FOA references drugs/biologics (linked to IND pathways) and devices (linked to IDE pathways) as the types of therapeutic candidates it intends to help advance through early preclinical development.
Is the FOA intended to fund a complete IND- or IDE-enabling package?
No. The intent is to fund early, focused translational work that advances the candidate to a clear next step, where a follow-on effort can credibly complete the remaining development activities needed to support an IND or IDE submission.
What is the Funding Opportunity Number (FON) for this program?
The Funding Opportunity Number is PAR-11-293.
Is this funding opportunity still active?
The record described is archived. Key dates include an archive date of February 7, 2013.
What are the key dates listed for this opportunity?
The archived record lists: posted date of August 8, 2011; an original closing date of September 7, 2012; a later closing date of January 7, 2013; and an archive date of February 7, 2013.
Where can applicants find the official FOA details?
The official announcement is linked at http://grants.nih.gov/grants/guide/pa-files/PAR-11-293.html.
Who should be contacted for assistance with access or linking issues for the FOA?
The notice routes assistance with access or linking issues through the NIH Office of Extramural Research webmaster contact listed in the announcement.
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