Opportunity Information: Apply for RFA NS 09 002
Apply for RFA NS 09 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NINDS Ischemic Stroke Genetics Consortium (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Feb 26, 2009 and posted on Feb 26, 2009.
- Applicants must submit their applications by May 15, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $900,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Native American tribal governments (Federally recognized) Independent school districts City or township governments Public and State controlled institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Special district governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NINDS Ischemic Stroke Genetics Consortium (U01) funding opportunity (RFA-NS-09-002) was a National Institutes of Health cooperative agreement designed to stand up a single, large, multi-center genome-wide association study (GWAS) consortium focused specifically on ischemic stroke. The core scientific aim was to identify genetic variants that influence both the risk of experiencing an ischemic stroke and the outcomes that follow a stroke. Rather than funding many separate projects, NINDS intended to support one coordinated consortium with common standards, centralized organization, and enough combined samples to produce statistically meaningful genetic findings.
A central feature of the announcement was the creation of a lasting, widely usable public resource. The consortium was expected to generate high-quality genotyping data linked to rigorously and uniformly phenotyped ischemic stroke cases, and then deposit those data into NIH's Database of Genotypes and Phenotypes (dbGaP). By doing that, the project would not only support the initial discovery analyses conducted by the funded group, but also enable broader scientific use later on, including replication studies, secondary analyses, subtype-focused research, and new hypothesis generation by investigators worldwide. In practical terms, the grant was structured to build an infrastructure and dataset that would outlive the award itself.
The FOA emphasized leveraging existing materials to move quickly and efficiently. Applicants were expected to concentrate on using existing DNA sample sets rather than launching entirely new large-scale collections from scratch. At the same time, the program stressed that genetic data alone would not be sufficient; samples needed to be paired with clinical information robust enough to support detailed endophenotyping and, critically, stroke subtype classification. This clinical depth was framed as essential not only for the primary GWAS, but also to make the dbGaP resource valuable for future studies that might focus on particular ischemic stroke subtypes or outcomes.
To ensure the consortium could function as a coherent enterprise, every application had to include plans for two major organizational components. First, a Data Coordinating Center (DCC) would be responsible for core coordination tasks such as data harmonization, phenotype standardization, quality control procedures, data management, and preparation of submissions to dbGaP. Second, one or more Genetic Research Centers (GRCs) would contribute the genotyping capacity and/or sample resources needed to generate the GWAS dataset. Together, the DCC and GRC components were expected to produce a sufficiently large, consistently phenotyped sample collection for meaningful GWAS power. The FOA provided an estimate that 6,000 or more samples would be an appropriate target sample size, signaling that applications needed to demonstrate realistic access to large numbers of cases and the ability to harmonize them into a single analyzable dataset.
A notable scientific requirement was the development of standardized, validated, and easily reproducible methods for assigning ischemic stroke subtypes. Because ischemic stroke is clinically heterogeneous, subtype misclassification can dilute genetic signals and undermine discovery. The announcement therefore pushed applicants to build consensus and implement approaches that could be replicated across sites and future studies. This standardization goal also aligned with the broader resource-building mission: dbGaP users would be able to trust that subtype labels were derived from methods that were explicit, tested, and applicable beyond a single institution.
From an administrative standpoint, the award mechanism was a U01 cooperative agreement, meaning NIH anticipated substantial involvement in the project beyond typical grant stewardship. The opportunity fell under the health activity category, carried no cost-sharing requirement, and anticipated making one award total. The award ceiling listed was $900,000. The FOA was posted on February 26, 2009, had an original and current closing date of May 15, 2009, and an archive date of June 15, 2009. The CFDA number associated with the program was 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
Eligibility was broad and included many types of domestic and non-domestic organizations. Eligible applicants included public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), local and state government entities, tribal governments and tribal organizations, independent school districts, public housing authorities, and special district governments. The eligibility description also explicitly mentioned a range of institution types and communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and foreign organizations.
Overall, the grant opportunity was structured around one clear idea: build a coordinated, high-powered ischemic stroke GWAS consortium that could produce credible genetic discoveries while simultaneously generating a permanent, well-phenotyped, well-documented dataset deposited to dbGaP. The emphasis on existing DNA collections, standardized subtype assignment, a formal DCC and GRC structure, and broad data sharing reflects a deliberate attempt to accelerate discovery while leaving behind a durable national (and effectively global) resource for the stroke genetics field.
Frequently Asked Questions (FAQs): NINDS Ischemic Stroke Genetics Consortium (U01) - RFA-NS-09-002
What is this funding opportunity?
This opportunity (RFA-NS-09-002) was a National Institutes of Health (NIH) cooperative agreement (U01) to establish a single, large, multi-center genome-wide association study (GWAS) consortium focused on ischemic stroke.
What was the main scientific goal of the consortium?
The core aim was to identify genetic variants that influence (1) the risk of experiencing an ischemic stroke and (2) outcomes that follow an ischemic stroke.
Was NIH planning to fund multiple projects or one consortium?
NIH intended to support one coordinated consortium rather than funding many separate projects. The design emphasized common standards, centralized organization, and pooled samples large enough for statistically meaningful genetic findings.
Why was building a public resource a central feature of the FOA?
The consortium was expected to create a lasting, widely usable resource by generating high-quality genotyping data linked to rigorously and uniformly phenotyped ischemic stroke cases, then depositing those data into NIH's Database of Genotypes and Phenotypes (dbGaP). This was meant to support both the original discovery analyses and broad future use by other investigators.
Where were the consortium data expected to be deposited?
Data were expected to be deposited into NIH's Database of Genotypes and Phenotypes (dbGaP).
What kinds of future research did the FOA envision using the dbGaP resource?
The FOA described broad downstream uses, including replication studies, secondary analyses, subtype-focused research, and new hypothesis generation by investigators worldwide.
Did the FOA expect applicants to collect new samples?
The FOA emphasized leveraging existing materials to move quickly and efficiently. Applicants were expected to concentrate on using existing DNA sample sets rather than starting entirely new large-scale sample collections from scratch.
What clinical information needed to accompany DNA samples?
Genetic data alone were not considered sufficient. Samples needed to be paired with robust clinical information to support detailed endophenotyping and, critically, ischemic stroke subtype classification.
Why was stroke subtype classification emphasized?
Ischemic stroke is clinically heterogeneous, and subtype misclassification can dilute genetic signals and undermine discovery. The FOA therefore required work toward standardized, validated, and easily reproducible subtype assignment methods.
What organizational components were required in every application?
Applications had to include plans for two major components: (1) a Data Coordinating Center (DCC) and (2) one or more Genetic Research Centers (GRCs).
What was the role of the Data Coordinating Center (DCC)?
The DCC was responsible for consortium-wide coordination tasks, including data harmonization, phenotype standardization, quality control procedures, data management, and preparation of submissions to dbGaP.
What was the role of the Genetic Research Center(s) (GRCs)?
GRCs were expected to contribute genotyping capacity and/or sample resources needed to generate the GWAS dataset.
What sample size did the FOA signal as an appropriate target?
The FOA provided an estimate that 6,000 or more samples would be an appropriate target, indicating applicants needed realistic access to large numbers of cases and the ability to harmonize them into a single analyzable dataset.
What does it mean that this was a U01 cooperative agreement?
A U01 is a cooperative agreement mechanism, meaning NIH anticipated substantial involvement in the project beyond typical grant stewardship.
How many awards were anticipated?
The FOA anticipated making one award total.
Was cost sharing required?
No cost-sharing requirement was indicated for this opportunity.
What was the award ceiling listed in the FOA?
The award ceiling listed was $900,000.
What was the health activity category?
The opportunity fell under the health activity category.
What is the CFDA number associated with this program?
The CFDA number associated with the program was 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
When was the FOA posted and when did it close?
The FOA was posted on February 26, 2009. The original and current closing date was May 15, 2009. The archive date was June 15, 2009.
Who was eligible to apply?
Eligibility was broad and included many types of domestic and non-domestic organizations. Eligible applicants included public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), local and state governments, tribal governments and tribal organizations, independent school districts, public housing authorities, and special district governments. The eligibility description also explicitly included HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, foreign organizations, and other institution types mentioned in the FOA.
Were foreign organizations included in eligibility?
Yes. The eligibility description explicitly included foreign organizations among the eligible applicants.
How did the FOA aim to ensure the consortium functioned as a single coherent effort?
It required a centralized DCC for harmonization, standardization, quality control, and data management; one or more GRCs to supply genotyping and/or samples; common standards across sites; and a coordinated approach designed to produce one sufficiently large, consistently phenotyped dataset.
What was the overall purpose of the opportunity in practical terms?
The opportunity was structured to build both (1) an infrastructure and coordinated consortium capable of high-powered ischemic stroke GWAS discovery and (2) a durable, well-phenotyped dataset deposited to dbGaP that would remain useful beyond the award period.
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