Opportunity Information: Apply for RFA NS 15 002
Apply for RFA NS 15 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NINDS Morris K. Udall Centers of Excellence for Parkinsons Disease Research (P50)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Jan 27, 2015 and posted on Dec 11, 2014.
- Applicants must submit their applications by Feb 19, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) County governments State governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses Private institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NINDS Morris K. Udall Centers of Excellence for Parkinsons Disease Research (P50) funding opportunity (RFA-NS-15-002) is a National Institutes of Health grant mechanism designed to build and sustain a coordinated network of Parkinsons disease research centers. The program is meant to push the field forward by supporting centers that can work both independently and in collaboration with other Udall Centers, with the shared objective of clarifying the causes of Parkinsons disease and accelerating progress toward better treatments. Each proposed Center is expected to function not just as a collection of individual labs, but as an integrated, interdisciplinary hub that can move ambitious research programs faster than would be possible through separate, stand-alone projects.
Scientifically, applications must be organized around a clear overall theme, and that theme must directly address Parkinsons disease etiology, pathogenesis, or treatment. Research on related synucleinopathies can be included, but only to the extent that it clearly and directly informs Parkinsons disease research rather than drifting into a separate disease focus. A central expectation is that the science is innovative and integrative, with a strong likelihood of producing meaningful discoveries. Review and funding decisions are driven heavily by potential impact: NINDS is looking for Centers whose work is most likely to substantially influence Parkinsons disease research and that also show strong potential to collaborate effectively across the broader Udall Center network.
From a structural standpoint, the FOA requires a true Center format with multiple interacting components. At minimum, an application must propose three research projects. In addition, applicants must include shared research cores that are not optional add-ons but essential infrastructure: each research core must be necessary to accomplish the aims of at least two of the proposed research projects. An Administrative Core is also required to provide leadership, coordination, communication, and overall management of the Center. A major theme running through the announcement is synergy: the projects and cores need to be interdependent in a way that makes it obvious the work could not be completed as effectively without the Center structure. In other words, NINDS is explicitly prioritizing Centers where the whole is greater than the sum of its parts.
Beyond the research itself, the FOA builds in expectations about people and community engagement. Each application must include a mission statement along with a concrete plan for career development of Parkinsons disease researchers, reflecting the program goal that Udall Centers act as local resources and national leaders while strengthening the pipeline of investigators in the field. Applicants must also provide a plan for outreach to the local patient community, underscoring that the Center should engage and serve patients and stakeholders, not operate in isolation from the community affected by Parkinsons disease.
Leadership and institutional commitment are treated as key predictors of success. The Center Director (PD/PI) must be an established scientific leader with demonstrated ability to steward large-scale research programs and provide visionary direction. The applicant institution is expected to show commitment to establishing and maintaining the proposed Center, implying that NINDS wants assurance the environment, support, and infrastructure are in place to make the Center productive and sustainable.
Administratively, this is a discretionary grant program in the health category using the P50 specialized center mechanism. The FOA anticipated making 2 awards, with an estimated total funding level of $4,500,000 and an award ceiling of $1,500,000. There is no cost sharing or matching requirement. The opportunity was posted December 11, 2014, created January 27, 2015, and had a closing date of February 19, 2015, with an archive date of March 21, 2015.
Eligibility is broad and includes many types of domestic organizations such as public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), for-profit organizations (including small businesses, with the noted limitation excluding for-profits that are small businesses in one field while allowing other for-profits in another), and various government entities (state, county, city/township, special district governments, and public housing authorities/Indian housing authorities). The FOA also lists additional eligible applicants such as HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, eligible federal agencies, faith-based or community-based organizations, and U.S. territories or possessions. Foreign organizations and foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible; however, foreign components as defined by NIH policy are allowed, which typically means certain parts of the work can be carried out internationally if appropriately justified and compliant with NIH rules.
In practical terms, an application that fits this FOA well would present a tightly integrated Parkinsons disease research agenda, show clearly how each project benefits from shared cores, demonstrate strong governance and coordination through the Administrative Core, and include credible plans for developing investigators and engaging patients locally. The applications most competitive for funding are those that convincingly combine high scientific ambition with realistic execution, strong leadership, and a clear strategy for collaboration within the national Udall Centers network.
Frequently Asked Questions (FAQs)
What is the NINDS Morris K. Udall Centers of Excellence for Parkinsons Disease Research (P50) opportunity?
This funding opportunity (RFA-NS-15-002) is a National Institutes of Health (NIH) program using the P50 specialized center mechanism to build and sustain a coordinated network of Parkinsons disease research centers (Udall Centers). The goal is to accelerate progress in understanding the causes of Parkinsons disease and advancing better treatments by supporting integrated, interdisciplinary Centers that work both independently and collaboratively across the Udall network.
What is the main purpose of the Udall Center program?
The program is designed to push the Parkinsons disease field forward by supporting Centers that can run ambitious, coordinated research programs faster and more effectively than separate stand-alone projects, while also collaborating across a national network of Udall Centers.
What types of research themes are required for an application?
Applications must be organized around a clear overall theme that directly addresses Parkinsons disease etiology, pathogenesis, or treatment. The theme needs to be central and explicit, and the overall scientific plan is expected to be innovative, integrative, and likely to produce meaningful discoveries.
Can research on related synucleinopathies be included?
Yes. Research on related synucleinopathies can be included only if it clearly and directly informs Parkinsons disease research. The intent is to avoid drifting into a separate disease focus that is not tightly connected to Parkinsons disease.
How does NINDS prioritize applications for review and funding?
Review and funding decisions are driven heavily by potential impact. NINDS is looking for Centers whose work is most likely to substantially influence Parkinsons disease research and that also demonstrate strong potential to collaborate effectively across the broader Udall Center network.
What makes this a true "Center" award rather than a collection of individual projects?
The FOA expects an integrated, interdisciplinary hub where the projects and cores are interdependent and synergistic. The application should make it obvious that the work could not be completed as effectively without the Center structure, meaning the whole should be greater than the sum of its parts.
What is the minimum required structure of a proposed Center?
At a minimum, an application must propose three research projects. In addition, the application must include shared research cores and a required Administrative Core to provide leadership, coordination, communication, and overall management.
Are shared research cores optional?
No. Shared research cores are essential infrastructure in this FOA, not optional add-ons.
What is the requirement for how research cores support the projects?
Each research core must be necessary to accomplish the aims of at least two of the proposed research projects. This requirement reinforces the expectation of integration and synergy across the Center.
What is the role of the Administrative Core?
The Administrative Core is required and is responsible for Center leadership, coordination, communication, and overall management, helping ensure the Center functions as a coherent, productive unit rather than isolated activities.
What expectations does the FOA include about career development?
Each application must include a mission statement along with a concrete plan for career development of Parkinsons disease researchers. This reflects the program goal that Udall Centers serve as local resources and national leaders while strengthening the pipeline of investigators in the field.
What outreach expectations are included for patient and community engagement?
Applicants must provide a plan for outreach to the local patient community. The FOA emphasizes that the Center should engage and serve patients and stakeholders and should not operate in isolation from the community affected by Parkinsons disease.
Who is expected to lead the Center as the PD/PI (Center Director)?
The Center Director (PD/PI) must be an established scientific leader with a demonstrated ability to steward large-scale research programs and provide visionary direction.
How important is institutional commitment in this opportunity?
Institutional commitment is treated as a key predictor of success. The applicant institution is expected to show commitment to establishing and maintaining the proposed Center, indicating that the environment, support, and infrastructure are in place to make the Center productive and sustainable.
What type of grant mechanism is used?
This is a discretionary grant program in the health category using the NIH P50 specialized center mechanism.
How many awards were anticipated, and what was the expected funding level?
The FOA anticipated making 2 awards, with an estimated total funding level of $4,500,000 and an award ceiling of $1,500,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What were the key dates for this opportunity?
The opportunity was posted December 11, 2014; created January 27, 2015; had a closing date of February 19, 2015; and an archive date of March 21, 2015.
What types of U.S. organizations were eligible to apply?
Eligibility is broad and includes many types of domestic organizations, such as public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), for-profit organizations (including small businesses, with a noted limitation described in the FOA), and various government entities (state, county, city/township, special district governments, and public housing authorities/Indian housing authorities).
Are minority-serving institutions and other specific organization types included in eligibility?
Yes. The FOA lists additional eligible applicants such as HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, eligible federal agencies, faith-based or community-based organizations, and U.S. territories or possessions.
Are foreign organizations or foreign institutions eligible to apply?
No. Foreign organizations and foreign institutions are not eligible to apply.
Can a U.S. organization include non-U.S. components in the application?
Non-U.S. components of U.S. organizations are not eligible. However, foreign components (as defined by NIH policy) are allowed, which generally means certain parts of the work may be carried out internationally if appropriately justified and compliant with NIH rules.
What does the FOA emphasize as the characteristics of a strong, competitive application?
A strong application is expected to present a tightly integrated Parkinsons disease research agenda; clearly show how each project benefits from shared cores; demonstrate strong governance and coordination through the Administrative Core; and include credible plans for developing investigators and engaging patients locally. The most competitive applications combine high scientific ambition with realistic execution, strong leadership, and a clear strategy for collaboration within the national Udall Centers network.
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