Opportunity Information: Apply for RFA NS 13 011
Apply for RFA NS 13 011
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NINDS Stroke Trials Network Regional Coordinating Stroke Centers (U10)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Feb 21, 2013 and posted on Feb 21, 2013.
- Applicants must submit their applications by May 15, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $8,750,000.00 to eligible and selected applicants.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) State governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments County governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Small businesses City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The NINDS Stroke Trials Network Regional Coordinating Stroke Centers (U10) funding opportunity (RFA-NS-13-011) is a National Institutes of Health cooperative agreement designed to build a coordinated, high-performing infrastructure for running multi-site stroke clinical trials. The core idea is to make stroke research faster, more consistent, and more efficient across many hospitals and research institutions by linking regional coordinating centers into a single national network. This network is meant to support a balanced slate of studies across the full stroke continuum: prevention (reducing stroke risk and recurrence), acute treatment (interventions delivered around the time of stroke), and recovery (rehabilitation and longer-term functional improvement).
Under this program, awardees serve as Regional Coordinating Stroke Centers within the larger NINDS Stroke Trials Network. These regional centers are expected to help develop, promote, and execute high-quality clinical trials that involve multiple sites, with an emphasis on rigorous operations, strong recruitment and retention practices, and consistent trial conduct across locations. The network is structured so that major trial coordination functions are centralized through separate National Clinical Coordinating and Data Management Centers, which handle key cross-network responsibilities for trial implementation and data. In practical terms, the regional centers plug into a broader system that is meant to reduce duplication, standardize procedures, and allow trials to ramp up more quickly.
The opportunity explicitly spans exploratory early-stage clinical trials (phase 1 and phase 2) as well as larger confirmatory phase 3 trials. It also includes biomarker validation studies, but specifically those that are immediately preparatory to clinical trials, meaning biomarker work that directly enables or strengthens near-term interventional studies rather than purely exploratory discovery. The overall goal is a streamlined pipeline where promising ideas can move more efficiently from early testing to definitive evaluation, using shared processes and coordinated oversight.
A major feature of the network model is operational efficiency. The announcement highlights the use of master trial agreements and a central institutional review board (IRB) as mechanisms to reduce administrative delays that typically slow down multi-site studies. Master agreements can simplify contracting across many institutions, while a central IRB can reduce redundant ethics review and enable faster site activation, without compromising participant protections. Together, these elements reflect a broader intent to modernize stroke trial execution so that high-priority studies can start sooner, enroll faster, and produce results with fewer procedural bottlenecks.
Another key expectation is that the scientists at these centers, including both clinical and basic researchers, will actively contribute to the intellectual engine of the network. This includes helping to develop clinical trial concepts and applications that can be submitted for peer review, as well as participating in planning and execution for stroke clinical trials funded by NINDS that originate outside the network. The network is also positioned to support trials that emerge from Collaborative Research and Development Agreements (CRADAs) between NINDS and industry partners, which signals an interest in facilitating well-governed public-private collaborations when they align with NINDS priorities.
The program also emphasizes readiness and interoperability with other research systems. The network is described as being uniquely poised to rapidly collaborate with other established networks, such as the NINDS Neurological Emergencies Treatment Trials Network (NETT), and with international consortia. This matters because stroke trials often require large sample sizes and broad geographic coverage to answer questions definitively, especially for acute treatment studies or when evaluating modest but clinically important effects. The ability to quickly align protocols and operations across networks is intended to make larger, more definitive trials feasible in a shorter timeframe.
Administratively, this opportunity is a discretionary NIH cooperative agreement (U10), meaning NIH is expected to have substantial involvement in the project’s conduct compared with a standard research project grant. The activity falls under the health category, with CFDA number 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders). The opportunity did not require cost sharing or matching. The total estimated funding amount listed for the announcement was $8,750,000.
Eligibility was broad across U.S.-based organizational types, spanning public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including those other than small businesses), small businesses, and multiple levels of government (state, county, city/township, special district, and independent school districts), as well as tribal governments and tribal organizations. The eligibility text also explicitly includes various mission-focused institution types such as HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations, along with eligible federal agencies and U.S. territories or possessions. Foreign institutions were not eligible, and foreign components of U.S. organizations were not allowed under NIH policy as described in the notice.
Key dates show the announcement was posted on February 21, 2013, with an original and current closing date of May 15, 2013, and an archive date of June 15, 2013. The sponsoring agency is the National Institutes of Health, and the announcement points applicants to the full funding opportunity text at the NIH grants site for detailed requirements, expectations, and application instructions. Contact support for access or linking issues is routed through the NIH Office of Extramural Research (OER) webmaster.
Frequently Asked Questions (FAQs)
What is the NINDS Stroke Trials Network Regional Coordinating Stroke Centers (U10) opportunity?
This is a National Institutes of Health (NIH) cooperative agreement (U10) funding opportunity (RFA-NS-13-011) intended to build a coordinated, high-performing infrastructure for multi-site stroke clinical trials by establishing Regional Coordinating Stroke Centers that operate as part of the larger NINDS Stroke Trials Network.
What is the main goal of this funding opportunity?
The goal is to make stroke research faster, more consistent, and more efficient across many hospitals and research institutions by linking regional coordinating centers into a single national network with shared processes and coordinated oversight.
What kinds of stroke studies does the network aim to support?
The network is meant to support a balanced slate of studies across the full stroke continuum, including prevention (reducing risk and recurrence), acute treatment (interventions around the time of stroke), and recovery (rehabilitation and longer-term functional improvement).
What role do awardees play under this program?
Awardees serve as Regional Coordinating Stroke Centers within the NINDS Stroke Trials Network and are expected to help develop, promote, and execute high-quality multi-site clinical trials with rigorous operations, strong recruitment and retention practices, and consistent trial conduct across locations.
How is the overall network organized?
Major trial coordination functions are centralized through separate National Clinical Coordinating and Data Management Centers, which handle key cross-network responsibilities for trial implementation and data. Regional Coordinating Stroke Centers connect into this broader system to reduce duplication and standardize procedures.
What trial phases are included in the scope of this opportunity?
The opportunity explicitly spans exploratory early-stage clinical trials (phase 1 and phase 2) as well as larger confirmatory phase 3 trials.
Are biomarker studies included?
Yes. The opportunity includes biomarker validation studies, specifically those that are immediately preparatory to clinical trials (biomarker work that directly enables or strengthens near-term interventional studies rather than purely exploratory discovery).
What does it mean that this is a cooperative agreement (U10)?
A U10 is an NIH cooperative agreement, which means NIH is expected to have substantial involvement in the project’s conduct compared with a standard research project grant.
How does this program aim to improve operational efficiency for multi-site trials?
The announcement highlights master trial agreements and the use of a central institutional review board (IRB) to reduce administrative delays common in multi-site studies, simplify contracting across institutions, and reduce redundant ethics review while maintaining participant protections.
What are master trial agreements in the context of this network?
Master trial agreements are described as a mechanism to simplify contracting across many institutions, helping to reduce administrative delays and speed up trial start-up for multi-site studies.
What is the purpose of a central IRB in this program?
A central IRB is intended to reduce redundant ethics review across participating sites and enable faster site activation without compromising participant protections.
Are Regional Coordinating Stroke Centers expected to contribute scientifically, not just operationally?
Yes. Scientists at these centers, including clinical and basic researchers, are expected to contribute to the network’s intellectual work by helping develop clinical trial concepts and applications for peer review and by participating in planning and execution of NINDS-funded stroke trials that originate outside the network.
Does the network support trials that involve industry collaborations?
The network is positioned to support trials that emerge from Collaborative Research and Development Agreements (CRADAs) between NINDS and industry partners when they align with NINDS priorities.
Can this network collaborate with other research networks?
Yes. The network is described as uniquely poised to rapidly collaborate with other established networks such as the NINDS Neurological Emergencies Treatment Trials Network (NETT) and with international consortia.
Why is interoperability with other networks and consortia important for stroke trials?
Stroke trials often require large sample sizes and broad geographic coverage, especially for acute treatment studies or when detecting modest but clinically important effects. Rapid alignment of protocols and operations across networks is intended to make larger, more definitive trials feasible in a shorter timeframe.
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), and the program is associated with the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Trials Network.
What is the CFDA number and program category associated with this opportunity?
The opportunity is listed under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) and falls under the health category.
Was cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
What was the total estimated funding amount for the announcement?
The total estimated funding amount listed was $8,750,000.
Who was eligible to apply?
Eligibility was broad across U.S.-based organizational types, including public and private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) entities); for-profit organizations (including those other than small businesses); small businesses; and multiple levels of government (state, county, city/township, special district, and independent school districts), as well as tribal governments and tribal organizations.
Are U.S. territories or possessions eligible?
Yes. The eligibility text explicitly includes U.S. territories or possessions.
Does the eligibility list include mission-focused institution types (for example, HBCUs and HSIs)?
Yes. The eligibility text explicitly includes institution types such as HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations, along with eligible federal agencies.
Are foreign institutions eligible to apply?
No. Foreign institutions were not eligible.
Are foreign components of U.S. organizations allowed?
No. Foreign components of U.S. organizations were not allowed under NIH policy as described in the notice.
When was the opportunity posted, and what were the key dates?
The announcement was posted on February 21, 2013. The original and current closing date was May 15, 2013. The archive date was June 15, 2013.
Where are applicants directed for detailed requirements and application instructions?
The announcement points applicants to the full funding opportunity text on the NIH grants site for detailed requirements, expectations, and application instructions.
Who should be contacted for access or linking issues related to the opportunity text?
Contact support for access or linking issues is routed through the NIH Office of Extramural Research (OER) webmaster.
Browse more opportunities from the same category: Health
Next opportunity: NINDS Stroke Trials Network National Clinical Coordinating Center (U01)
Previous opportunity: Afghanistan Is Getting Better Website and Story Corps
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA NS 13 011
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA NS 13 011) also looked into and applied for these:
| Funding Opportunity |
|---|
| NINDS Stroke Trials Network National Clinical Coordinating Center (U01) Apply for RFA NS 13 012 Funding Number: RFA NS 13 012 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| INNOVATE FOR HEALTH DRAFT APS Apply for 641 DRAFT 13 000001 Funding Number: 641 DRAFT 13 000001 Agency: Ghana USAID Accra Category: Health Funding Amount: $14,300,000 |
| Cooperative Agreement for the Strengthening and the Development of Applied Epidemiology and Sustainable Public Health Capacity through Collaboration, Program Development and Implementation, Communication and Information Sharing Apply for CDC RFA GH10 100604CONT13 Funding Number: CDC RFA GH10 100604CONT13 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| FY 2013 Cooperative Agreements for Screening, Brief Intervention, and Referral to Treatment Apply for TI 13 012 Funding Number: TI 13 012 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $2,003,000 |
| Drug Free Communities Mentoring Program Apply for SP 13 003 Funding Number: SP 13 003 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $75,000 |
| HIV Co infection Surveillance Strategies for Program Planning in the Central America Region under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1344 Funding Number: CDC RFA GH13 1344 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Improving HIV/AIDS Surveillance and Program Evaluation in Cote dIvoire (ISPEC) under the Presidents Emergency Plan for HIV/AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1352 Funding Number: CDC RFA GH13 1352 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $2,000,000 |
| Technical Assistance in Support of HIV Prevention, Care and Treatment Services in the Republic of Cote d Ivoire under the Presidents Emergency Plan for HIV/AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1353 Funding Number: CDC RFA GH13 1353 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $2,000,000 |
| Comprehensive HIV Prevention, Care and Treatment for the National Defense Force of Ethiopia (NDFE) under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1312 Funding Number: CDC RFA GH13 1312 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,500,000 |
| Development and Translation of Medical Technologies to Reduce Health Disparities (SBIR) (R43/R44) Apply for RFA EB 13 002 Funding Number: RFA EB 13 002 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Strategic Assessments for Strategic Action (SASA) in India under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1361 Funding Number: CDC RFA GH13 1361 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,000,000 |
| Technical Assistance to National AIDS Control Program (NACP) in India for Strategic Planning and Decision Making under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1362 Funding Number: CDC RFA GH13 1362 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $500,000 |
| Establishment of a Strategic Partnership to Strengthen the South African National AIDS Council under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1338 Funding Number: CDC RFA GH13 1338 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $2,000,000 |
| Partnerships for Biodefense (R01) Apply for RFA AI 13 013 Funding Number: RFA AI 13 013 Agency: National Institutes of Health Category: Health Funding Amount: $750,000 |
| Strengthening the South African National Department of Health (NDOH) to implement and evaluate evidence based public health program, surveillance and disease control efforts under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1337 Funding Number: CDC RFA GH13 1337 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $10,000,000 |
| Strengthening strategic information, program implementation and capacity building in order to reduce morbidity and mortality in the Republic of South Africa under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1340 Funding Number: CDC RFA GH13 1340 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $10,000,000 |
| Strengthen capacity of the South African Governments Department of Health to provide quality and sustainable clinical care for HIV infected patients with complicated HIV and HIV/TB treatment management, including 2nd and 3rd line and other antiretrov Apply for CDC RFA GH13 1335 Funding Number: CDC RFA GH13 1335 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $5,000,000 |
| Comprehensive HIV TB Prevention, Care and Treatment Services and Systems Strengthening, In Facilities of South Africas Department of Correctional Services (DCS) under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1336 Funding Number: CDC RFA GH13 1336 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $12,000,000 |
| Building Capacity of the Vietnam Health System through Provision of HIV/AIDS Clinical Care Mentorship and Technical Assistance under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1363 Funding Number: CDC RFA GH13 1363 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,500,000 |
| Sustaining Influenza Surveillance Networks and Response to Seasonal and Pandemic Influenza by National Health Authorities outside the United States Apply for CDC RFA IP13 1304 Funding Number: CDC RFA IP13 1304 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $500,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA NS 13 011", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.