Opportunity Information: Apply for RFA DK 12 024
Apply for RFA DK 12 024
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Nociceptive GenitoUrinary Development Molecular Anatomy Projects (nGUDMAP) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Nov 26, 2012 and posted on Nov 26, 2012.
- Applicants must submit their applications by Mar 14, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal governments (Federally recognized) State governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities For profit organizations other than small businesses County governments City or township governments Independent school districts Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH Funding Opportunity Announcement RFA-DK-12-024, titled "Nociceptive GenitoUrinary Development Molecular Anatomy Projects (nGUDMAP) (U01)," supports cooperative agreement awards aimed at building a detailed molecular anatomy atlas in mice focused specifically on nociceptors (pain-sensing neurons) and the related cell types involved in pain processing within the urinary tract and broader pelvic region. The central idea is to create an organized, high-resolution reference map that captures where these pain-related cells are, how they develop, and how they differ from one another at anatomical, developmental, and biochemical levels. By systematically defining these cell populations and their developmental origins, the program is intended to provide foundational knowledge that can be leveraged over time to inform new diagnostics and treatments for urologic chronic pelvic pain syndromes (UCPPS), including conditions historically labeled Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS).
This FOA invites two main kinds of efforts: Research Projects and Atlas Assembly Projects. Research Projects are generally expected to generate new primary data about the identity, distribution, and characteristics of urinary and pelvic nociceptors and the supporting or interacting cell types that participate in pain pathways. Atlas Assembly Projects are geared toward organizing, integrating, and presenting those kinds of datasets into an accessible atlas framework, emphasizing standardized assembly, annotation, and usability so that the resulting atlas can serve as a lasting community resource. The overall expectation is not just isolated findings, but a coherent, interoperable atlas-style product that helps the field compare results across studies and laboratories, and that clarifies heterogeneity (for example, distinct nociceptor subtypes and neighboring cell populations that may contribute differently to pain signaling).
The award mechanism is a U01 cooperative agreement, meaning NIH anticipates substantial programmatic involvement compared with a typical investigator-initiated grant. In practice, this usually aligns with multi-team coordination, shared standards for data generation and reporting, and integration with an existing program structure. Successful applicants are explicitly described as becoming part of the ongoing GenitoUrinary Development Molecular Anatomy Project (GUDMAP) effort, building on prior GUDMAP initiatives referenced in the announcement (RFA DK 11 001 and RFA DK 10 005). That linkage signals an emphasis on continuity with established atlas-building practices, shared resources, and coordinated data-sharing approaches that are typical of large-scale biomedical mapping programs.
Administratively, the opportunity is listed under NIH with CFDA number 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), and it was posted on November 26, 2012, with an original and current closing date of March 14, 2013, and an archive date of April 14, 2013. The estimated total funding amount is stated as $1,500,000, and there is no cost-sharing or matching requirement. Eligibility is broad and includes many U.S. organizational types, such as nonprofit organizations (with or without 501(c)(3) status), small businesses, for-profit organizations (other than small businesses), public and private institutions of higher education, state and local governments, tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and a range of specialized institution categories (including HBCUs, Hispanic-serving institutions, AANAPISIs, and tribally controlled colleges and universities). Importantly, foreign participation is allowed: non-U.S. entities (foreign organizations and foreign institutions) may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are permitted as defined by the NIH Grants Policy Statement.
In practical terms, the opportunity is designed to accelerate a shared, community-oriented atlas that clarifies the cellular and molecular landscape of pelvic and urinary pain circuitry in a well-defined mammalian model. By deeply characterizing nociceptor diversity and the surrounding cellular environment in development and in anatomical context, the program aims to reduce a major bottleneck in pelvic pain research: the lack of a comprehensive, standardized reference map that links cell identity to location, lineage, and molecular features. The intended downstream payoff is to make it easier to identify plausible therapeutic targets and to translate mechanistic insights into strategies that could eventually improve care for people living with chronic pelvic pain conditions.
For full details, NIH directed applicants to the announcement page at http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-12-024.html, and provided NIH Office of Extramural Research (OER) webmaster contacts for access or technical issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the name and number of this NIH funding opportunity?
This opportunity is NIH Funding Opportunity Announcement (FOA) RFA-DK-12-024, titled "Nociceptive GenitoUrinary Development Molecular Anatomy Projects (nGUDMAP) (U01)."
What is the overall purpose of RFA-DK-12-024?
The FOA supports projects that build a detailed, high-resolution molecular anatomy atlas in mice focused on nociceptors (pain-sensing neurons) and related cell types involved in pain processing in the urinary tract and broader pelvic region. The goal is to create an organized reference map that shows where these cells are, how they develop, and how they differ anatomically, developmentally, and biochemically.
What conditions or research areas is this program meant to support in the long run?
The program is intended to generate foundational knowledge that can eventually inform diagnostics and treatments for urologic chronic pelvic pain syndromes (UCPPS), including conditions historically labeled Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) and Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS).
What kinds of projects does the FOA invite?
The FOA invites two main categories: (1) Research Projects and (2) Atlas Assembly Projects.
What is a Research Project under this FOA expected to do?
Research Projects are generally expected to generate new primary data about the identity, distribution, and characteristics of urinary and pelvic nociceptors, as well as supporting or interacting cell types that participate in pain pathways.
What is an Atlas Assembly Project under this FOA expected to do?
Atlas Assembly Projects are geared toward organizing, integrating, and presenting relevant datasets into an accessible atlas framework. These projects emphasize standardized assembly, annotation, and usability so the atlas functions as a lasting community resource.
Is the expected outcome individual findings, or an integrated atlas resource?
The expectation is not just isolated findings. The FOA emphasizes a coherent, interoperable atlas-style product that helps researchers compare results across studies and laboratories and clarifies heterogeneity among cell populations (for example, distinct nociceptor subtypes and neighboring cell types that may contribute differently to pain signaling).
What organism/model system is the atlas focused on?
The atlas described in the FOA is focused on mice, with an emphasis on nociceptors and pain-related cell types in the urinary tract and pelvic region.
What does "nociceptive" refer to in this program?
In the context of this FOA, "nociceptive" refers to nociceptors, which are pain-sensing neurons, and the program also includes related cell types involved in pain processing and pain pathways in urinary and pelvic tissues.
What is meant by "molecular anatomy atlas" in this announcement?
Based on the FOA description, the atlas is a structured reference map intended to capture cell identity and diversity along with anatomical location, developmental context (including developmental origins), and molecular/biochemical characteristics.
What grant mechanism is used, and what does it imply?
The mechanism is a U01 cooperative agreement. This indicates NIH anticipates substantial programmatic involvement compared with a typical investigator-initiated grant, often including coordination across teams, shared standards for data generation and reporting, and integration with an existing program structure.
How is this FOA connected to GUDMAP?
Successful applicants are described as becoming part of the ongoing GenitoUrinary Development Molecular Anatomy Project (GUDMAP) effort. The FOA also references prior GUDMAP initiatives (RFA DK 11 001 and RFA DK 10 005), signaling continuity with established atlas-building practices, shared resources, and coordinated data-sharing approaches.
Which NIH program area/CFDA listing is associated with this opportunity?
The opportunity is listed under NIH with CFDA number 93.847, described as Diabetes, Digestive, and Kidney Diseases Extramural Research.
When was the opportunity posted, and what were the key dates?
The FOA was posted on November 26, 2012. The original and current closing date is listed as March 14, 2013, and the archive date is April 14, 2013.
How much total funding is estimated for this opportunity?
The estimated total funding amount stated in the FOA information provided is $1,500,000.
Is cost sharing or matching required?
No. The information provided states there is no cost-sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many U.S. organizational types: nonprofit organizations (with or without 501(c)(3) status), small businesses, for-profit organizations (other than small businesses), public and private institutions of higher education, state and local governments, tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and specialized institution categories such as HBCUs, Hispanic-serving institutions, AANAPISIs, and tribally controlled colleges and universities.
Are foreign organizations allowed to apply?
Yes. The FOA information provided states that non-U.S. entities (foreign organizations and foreign institutions) may apply. It also states that non-U.S. components of U.S. organizations are eligible and that foreign components are permitted as defined by the NIH Grants Policy Statement.
What research gap is this program trying to address?
The FOA is designed to reduce a major bottleneck in pelvic pain research: the lack of a comprehensive, standardized reference map that links cell identity to location, lineage/developmental origin, and molecular features for pelvic and urinary pain circuitry.
What is the intended downstream benefit of creating this atlas?
The intended payoff is to make it easier for the field to identify plausible therapeutic targets and translate mechanistic insights into strategies that could eventually improve care for people living with chronic pelvic pain conditions.
Where can applicants find the full FOA details?
NIH directed applicants to the announcement page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-12-024.html
Who should be contacted for access or technical issues related to the announcement page?
For access or technical issues, NIH provided the NIH Office of Extramural Research (OER) webmaster contact: FBOWebmaster@OD.NIH.GOV
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