Opportunity Information: Apply for RFA AI 11 039
Apply for RFA AI 11 039
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Nonhuman Primate Islet/Kidney Transplantation Tolerance (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.855 Allergy and Infectious Diseases Research.
- This funding opportunity was created on Aug 17, 2011 and posted on Aug 17, 2011.
- Applicants must submit their applications by Dec 14, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts City or township governments State governments For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Small businesses Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Nonhuman Primate Islet/Kidney Transplantation Tolerance (U01) opportunity (RFA-AI-11-039) is a National Institutes of Health (NIH) cooperative agreement run jointly by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It funds research teams to take part specifically in the islet and kidney transplant model components of the broader Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG), which is a multicenter program using nonhuman primate (NHP) transplantation models as a high-value preclinical bridge to human clinical transplantation.
At its core, the program is focused on immune tolerance in transplantation, meaning strategies that help a transplant recipient accept a graft long-term with minimal ongoing immunosuppression. Within the NHPCSG, investigators work in NHP models of kidney, islet, heart, and lung transplantation; this particular funding announcement is aimed at groups able to conduct and contribute to the kidney and islet arms. The scientific goals are twofold: first, to test the preclinical safety and efficacy of tolerance induction regimens, including both established approaches and newer therapies as they emerge; and second, to clarify the biology behind how tolerance is induced, maintained over time, or lost, using mechanistic studies that can explain why a regimen succeeds or fails. The long-range intent is very practical and translational: to identify and refine tolerance protocols that can meaningfully improve long-term graft survival and outcomes in clinical transplantation.
Because the award mechanism is a U01 cooperative agreement, the expectation is not a stand-alone project operating in isolation, but an active role within a coordinated, collaborative network. In cooperative agreements, NIH typically has substantial programmatic involvement compared with a standard research grant, and applicants should generally be prepared for structured coordination, shared standards, and participation in group-driven planning and data sharing that supports cross-site comparability. The announcement explicitly invites applications from either single institutions or consortia, which signals that applicants can propose either a centralized transplant model capability or a multi-institution arrangement that combines surgical expertise, immunology, pathology, and specialized assays to deliver robust, reproducible NHP transplantation studies.
The opportunity is categorized as discretionary funding and lists activity areas aligned with health research, tied to CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). Cost sharing is not required, which lowers barriers for academic and nonprofit groups and makes the program accessible to applicants that can meet the scientific and infrastructure demands without needing to contribute matching funds.
Eligibility is broad across U.S.-based organizations and governmental entities, including public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, and a range of governmental bodies (state, county, city/township, special district). It also explicitly includes various mission-driven and capacity-building institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, among others. At the same time, the announcement makes clear that non-U.S. entities cannot apply as the primary applicant organization, and non-U.S. components of U.S. organizations are not eligible to apply; however, foreign components are allowed as defined by NIH policy, which generally means a U.S. applicant may include certain international elements when justified and compliant with NIH rules.
Key logistics in the provided record show the FOA was posted on August 17, 2011, with an original and current closing date of December 14, 2011, and an archive date of January 14, 2012. The full announcement was made available through the NIH Grants Guide at the listed link (RFA-AI-11-039). For access or technical issues, the contact point provided is the NIH Office of Extramural Research (OER) webmaster email.
FAQs: Nonhuman Primate Islet/Kidney Transplantation Tolerance (U01) (RFA-AI-11-039)
What is this funding opportunity?
This opportunity is the Nonhuman Primate Islet/Kidney Transplantation Tolerance (U01) program (RFA-AI-11-039), a National Institutes of Health (NIH) cooperative agreement. It supports research teams conducting nonhuman primate (NHP) transplantation studies focused on the islet and kidney transplant model components of a larger multicenter program.
Which NIH institutes run this program?
The cooperative agreement is run jointly by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What broader program does this FOA fit into?
The award supports participation in the Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG), a multicenter program that uses NHP transplantation models as a preclinical bridge to human clinical transplantation.
Which transplant models are covered by the overall cooperative study group, and which are targeted by this FOA?
Across the NHPCSG, investigators work in NHP models of kidney, islet, heart, and lung transplantation. This specific FOA is aimed at groups able to conduct and contribute to the kidney and islet arms.
What is the main scientific focus of the program?
The core focus is immune tolerance in transplantation: strategies intended to enable long-term acceptance of a graft with minimal ongoing immunosuppression.
What are the primary scientific goals of the funded work?
The goals are twofold: (1) to test the preclinical safety and efficacy of tolerance induction regimens (including established approaches and newer therapies as they emerge), and (2) to clarify the underlying biology of how tolerance is induced, maintained, or lost through mechanistic studies that explain success or failure of a regimen.
What is the long-range intent or translational goal?
The long-range intent is to identify and refine tolerance protocols that can improve long-term graft survival and outcomes in clinical transplantation.
What does it mean that this is a U01 cooperative agreement?
A U01 is a cooperative agreement, which generally implies substantial NIH programmatic involvement compared with a standard research grant. The expectation is active participation in a coordinated, collaborative network rather than a stand-alone project operating in isolation.
What kinds of collaboration and coordination are implied by this cooperative agreement?
Applicants should be prepared for structured coordination, shared standards, and participation in group-driven planning and data sharing to support cross-site comparability within the multicenter program.
Can applications be submitted by a single institution, or do they need to be a consortium?
The announcement explicitly invites applications from either single institutions or consortia. This allows proposals that are centralized at one site or distributed across multiple institutions to assemble the needed expertise and capabilities.
What capabilities or expertise does the FOA suggest teams may need?
The record indicates that applicants may propose capabilities spanning transplant model work and specialized expertise such as surgical capability, immunology, pathology, and specialized assays to support robust and reproducible NHP transplantation studies.
What type of funding is this categorized as?
The opportunity is categorized as discretionary funding.
Which CFDA numbers are associated with this opportunity?
The CFDA numbers listed are 93.855 (Allergy and Infectious Diseases Research) and 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Is cost sharing or matching required?
No. Cost sharing is not required.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and governmental entities. Examples listed include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, and various governmental bodies (state, county, city/township, special district).
Does the FOA explicitly include certain institution types such as HBCUs or tribal colleges?
Yes. The record explicitly includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and also mentions faith-based or community-based organizations, among others.
Are non-U.S. organizations eligible to apply as the primary applicant?
No. The announcement states that non-U.S. entities cannot apply as the primary applicant organization.
Are non-U.S. components of U.S. organizations eligible to apply?
No. The record states that non-U.S. components of U.S. organizations are not eligible to apply.
Are foreign components allowed at all under this FOA?
Yes. The record indicates that foreign components are allowed as defined by NIH policy, meaning a U.S. applicant may include certain international elements when justified and compliant with NIH rules.
When was this FOA posted?
The record shows the FOA was posted on August 17, 2011.
What were the application due date and closing date?
The original and current closing date shown in the record is December 14, 2011.
When was this opportunity archived?
The archive date listed is January 14, 2012.
Where was the full announcement made available?
The full announcement was made available through the NIH Grants Guide under the identifier RFA-AI-11-039.
Who should be contacted for access or technical issues related to the announcement record?
The contact point provided for access or technical issues is the NIH Office of Extramural Research (OER) webmaster email.
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