Opportunity Information: Apply for RFA AI 11 040
Apply for RFA AI 11 040
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Nonhuman Primate Islet/Kidney Transplantation Tolerance (U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.855 Allergy and Infectious Diseases Research.
- This funding opportunity was created on Aug 17, 2011 and posted on Aug 17, 2011.
- Applicants must submit their applications by Dec 14, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) County governments City or township governments Independent school districts Public and State controlled institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Small businesses State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Nonhuman Primate Islet/Kidney Transplantation Tolerance (U19) funding opportunity (RFA-AI-11-040) is a National Institutes of Health cooperative agreement designed to support research teams working in nonhuman primate (NHP) models of islet and kidney transplantation. It is jointly sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The award sits within the broader Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG), which is a multi-center, collaborative program focused on improving outcomes in transplantation by developing and rigorously testing immune tolerance strategies in clinically relevant primate models.
At its core, this program targets one of the biggest problems in transplantation: the need for lifelong immunosuppression and the long-term graft damage that can still occur even when rejection is controlled. The NHPCSG uses NHP models because they tend to mirror human immunology and transplant biology more closely than rodent systems, making them especially valuable for preclinical evaluation. Within the larger NHPCSG framework that also includes heart and lung transplantation models, this specific announcement concentrates on the islet and kidney portions, supporting studies that can bridge promising tolerance approaches toward eventual clinical application.
The scientific goals emphasize both translation and mechanism. On the translational side, applicants are expected to evaluate the preclinical safety and efficacy of immune tolerance induction regimens, including both established protocols and newly developed strategies. This can include testing whether a regimen can reliably produce durable acceptance of transplanted islets or kidneys, reduce or eliminate the need for chronic immunosuppressive drugs, and improve overall graft longevity. On the mechanistic side, the program prioritizes understanding how tolerance is induced, how it is maintained over time, and why it sometimes fails. In practice, that means studies that dissect immune pathways and cellular players involved in tolerance, and that can generate evidence explaining success or loss of graft acceptance in these NHP transplant settings.
The long-range aim is explicitly clinical: to develop and evaluate tolerance induction regimens that ultimately improve long-term graft survival in human transplantation. The expectation is that funded projects will contribute to a coordinated, multi-site effort where results are comparable and informative across studies, helping the field converge on the most promising approaches. Because this is a cooperative agreement (U19), the NIH role is typically more active than in a standard investigator-initiated grant, with an emphasis on collaboration, coordinated planning, and shared program goals consistent with a cooperative study group model.
From an administrative standpoint, the opportunity was posted on August 17, 2011, with an original and current closing date of December 14, 2011, and it was archived on January 14, 2012. The program falls under NIH assistance listings 93.855 (Allergy and Infectious Diseases Research) and 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). There is no cost sharing or matching requirement indicated.
Eligibility is broad across U.S.-based organizations and includes public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses and other than small businesses), and a wide range of governmental entities (state, county, city/township, special district governments, and certain housing authorities). The eligibility language also explicitly includes several institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, and U.S. territories or possessions, among others. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible; however, foreign components are allowed as defined by NIH policy, which generally means specific, well-justified elements of a project may be performed abroad under NIH rules even though the applicant organization must be domestic.
The issuing agency is the NIH, and the announcement provides a standard NIH contact path for technical access issues through the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV). The full announcement was originally available through the NIH Grants Guide at the provided link (http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-11-040.html), which typically contains the detailed requirements for applications, expected components for a U19 structure, and the cooperative study group expectations for coordination and reporting.
FAQs: Nonhuman Primate Islet/Kidney Transplantation Tolerance (U19) (RFA-AI-11-040)
What is this funding opportunity?
This opportunity, titled "Nonhuman Primate Islet/Kidney Transplantation Tolerance (U19)" (RFA-AI-11-040), is an NIH cooperative agreement that supports research teams working in nonhuman primate (NHP) models of islet and kidney transplantation with a focus on immune tolerance strategies.
Which NIH institutes sponsor this program?
It is jointly sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What does "U19 cooperative agreement" mean in this context?
The opportunity uses a cooperative agreement mechanism (U19), which typically involves a more active NIH role than a standard investigator-initiated research grant. The emphasis is on collaboration, coordinated planning, and shared program goals consistent with a cooperative study group model.
How does this opportunity fit into the larger NHPCSG program?
This award sits within the broader Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG), a multi-center collaborative program aimed at improving transplantation outcomes by developing and rigorously testing immune tolerance strategies in clinically relevant primate models.
What transplant areas does this specific announcement focus on?
Within the NHPCSG framework (which also includes heart and lung transplantation models), this specific announcement concentrates on the islet and kidney portions of the overall program.
What problem in transplantation is the program trying to address?
The program targets the need for lifelong immunosuppression and the long-term graft damage that can still occur even when rejection is controlled. It aims to advance immune tolerance approaches that could reduce or eliminate chronic immunosuppressive drug use and improve long-term graft survival.
Why are nonhuman primate (NHP) models used?
NHP models are used because they tend to mirror human immunology and transplant biology more closely than rodent systems, making them especially valuable for preclinical evaluation of tolerance strategies intended to move toward clinical application.
What are the main scientific goals of the program?
The goals emphasize both translation and mechanism. Translationally, applicants are expected to evaluate the preclinical safety and efficacy of immune tolerance induction regimens. Mechanistically, the program prioritizes understanding how tolerance is induced, maintained, and why it sometimes fails.
What kinds of tolerance strategies are in scope?
The opportunity includes evaluating both established protocols and newly developed strategies for immune tolerance induction in NHP islet and kidney transplantation models.
What types of outcomes are applicants expected to evaluate?
Based on the description, expected outcomes include whether a regimen can reliably produce durable acceptance of transplanted islets or kidneys, reduce or eliminate the need for chronic immunosuppressive drugs, and improve overall graft longevity.
What does the program mean by "mechanistic" studies?
Mechanistic work refers to studies that dissect immune pathways and cellular players involved in tolerance, and that can generate evidence explaining success or loss of graft acceptance in these NHP transplant settings.
Is the long-term aim clinical translation?
Yes. The long-range aim is explicitly clinical: to develop and evaluate tolerance induction regimens that ultimately improve long-term graft survival in human transplantation.
Is collaboration across sites expected?
Yes. The program is described as a coordinated, multi-site effort where results are intended to be comparable and informative across studies, helping the field converge on the most promising approaches.
When was this opportunity posted and when did it close?
It was posted on August 17, 2011. The original and current closing date was December 14, 2011. It was archived on January 14, 2012.
Is this opportunity still active?
No. The listing states it was archived on January 14, 2012, and the closing date was December 14, 2011.
What are the NIH assistance listing numbers associated with this program?
The program falls under NIH assistance listings 93.855 (Allergy and Infectious Diseases Research) and 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Is cost sharing or matching required?
No cost sharing or matching requirement is indicated in the provided information.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and includes public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses and other than small businesses), and various governmental entities (state, county, city/township, special district governments, and certain housing authorities).
Are specific institution types explicitly included?
Yes. The eligibility language explicitly includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, and U.S. territories or possessions, among others.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply based on the provided information.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed at all?
Yes. Foreign components are allowed as defined by NIH policy. In practical terms, this generally means specific, well-justified elements of a project may be performed abroad under NIH rules, even though the applicant organization must be domestic.
Who is the issuing agency?
The issuing agency is the National Institutes of Health (NIH).
Where could applicants find the full announcement details?
The full announcement was available via the NIH Grants Guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-11-040.html, which typically includes detailed application requirements, expected components for a U19 structure, and cooperative study group expectations for coordination and reporting.
Who should be contacted for technical access issues?
The announcement provides a standard NIH contact path for technical access issues through the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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