Opportunity Information: Apply for RFA AI 15 038
Apply for RFA AI 15 038
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Nonhuman Primate Reagent Resource (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Aug 12, 2015 and posted on Aug 12, 2015.
- Applicants must submit their applications by Dec 11, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,600,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Special district governments Native American tribal governments (Federally recognized) City or township governments For profit organizations other than small businesses County governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Nonhuman Primate Reagent Resource (U24) opportunity (RFA-AI-15-038) is a National Institutes of Health cooperative agreement designed to build and operate a centralized immunologic reagent resource that makes nonhuman primate (NHP) models easier to use, more reliable, and more informative for biomedical research. The main goal is to remove a persistent bottleneck in NHP studies: investigators often lack well-validated, NHP-optimized immunology reagents (or the information needed to choose them confidently), which slows progress in vaccine and adjuvant development and in studies of infectious diseases and immune-mediated conditions, including transplantation.
Under this FOA, the awardee is expected to identify which reagents the NHP research community most urgently needs, then obtain or create those reagents and take them through the practical steps that make them truly useful in real experiments. That includes development and optimization for NHP use, careful characterization and performance evaluation, and then actual production and distribution so the broader scientific community can access them. The emphasis is on reagents that are not commercially available at all, or that may exist commercially but are not optimized for NHP species and therefore do not perform consistently or are not properly validated for NHP cells or proteins. The intention is that the resource functions as a dependable pipeline from “need identified” to “reagent in researchers’ hands,” with quality and usability as central expectations.
A major required component is information infrastructure. The resource must develop and provide a public website and also provide, or contribute to and link with, a searchable database that helps researchers find immunologic reagents (both commercial and non-commercial) known to cross-react with NHP targets. In practice, this means the project is not just generating new tools, but also organizing knowledge about existing tools so researchers can quickly determine what works in which NHP species, for what application, and with what performance characteristics. By making cross-reactivity and validation information easier to locate, the program aims to reduce duplicated trial-and-error testing across labs and to increase comparability and reproducibility across studies.
Programmatically, this is a cooperative agreement (U24), which signals that NIH expects substantial involvement from the agency in steering or coordinating aspects of the effort, consistent with building a community-facing resource rather than supporting a single-lab research project. The award structure indicates an expected single award, with an estimated total funding level of $1,600,000 for the FOA. The activity category is Health, and the relevant CFDA numbers are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research). There is no cost sharing or matching requirement listed.
Eligibility is broad and includes many types of U.S.-based organizations: public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), small businesses, for-profit organizations other than small businesses, state and local governments (including city/township, county, special district), independent school districts, public housing authorities/Indian housing authorities, and tribal governments and organizations (including federally recognized tribes and other tribal entities). The FOA also explicitly includes a range of mission-focused institution types such as HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations, among others. Non-U.S. (foreign) organizations and foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible; however, foreign components as defined in the NIH Grants Policy Statement are allowed, which typically means certain project elements may be carried out abroad when appropriately justified and permitted under NIH policy.
Key dates for this archived opportunity were posted/created on August 12, 2015, with an original and current closing date of December 11, 2015, and an archive date of January 11, 2016. The agency is the NIH, and the full announcement was provided through the NIH Grants Guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-15-038.html. For technical access issues, the contact listed is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, the FOA is focused on enabling faster and more rigorous NHP-based immunology research by building a curated, production-capable reagent resource paired with a public-facing web and database presence. The intended downstream impact is straightforward: better access to validated NHP immunologic reagents and better visibility into what already works should accelerate studies aimed at vaccines, treatments, and cures for immune-mediated diseases as well as emerging and re-emerging infectious diseases, while also improving consistency and efficiency across the NHP research community.
FAQs: Nonhuman Primate Reagent Resource (U24) (RFA-AI-15-038)
What is the Nonhuman Primate Reagent Resource (U24) opportunity?
It is a National Institutes of Health (NIH) cooperative agreement (U24) funding opportunity (RFA-AI-15-038) to build and operate a centralized immunologic reagent resource. The resource is meant to make nonhuman primate (NHP) models easier to use, more reliable, and more informative for biomedical research by improving access to well-validated, NHP-optimized immunology reagents and the information needed to select them confidently.
What problem is this program trying to solve?
The FOA targets a persistent bottleneck in NHP studies: investigators often do not have access to well-validated immunology reagents optimized for NHP species (or clear information about which reagents work). This lack of validated tools and cross-reactivity information slows progress, increases trial-and-error testing, and can reduce reproducibility across labs.
What is the main goal of the funded resource?
The central goal is to operate a dependable pipeline that goes from identifying high-priority reagent needs in the NHP research community to developing/obtaining, optimizing, characterizing, producing, and distributing those reagents so they are usable in real experiments.
What kinds of reagents are emphasized under this FOA?
The emphasis is on immunologic reagents that are not commercially available, or reagents that may exist commercially but are not optimized for NHP species and therefore do not perform consistently or are not properly validated for NHP cells or proteins.
What are the expected activities of the awardee?
Based on the FOA description, the awardee is expected to: identify urgent reagent needs in the NHP community; obtain or create those reagents; perform development and optimization for NHP use; conduct careful characterization and performance evaluation; and then produce and distribute reagents so they are accessible to the broader scientific community.
Does the program require building an information platform (website/database)?
Yes. A major required component is information infrastructure. The resource must develop and provide a public website and also provide, or contribute to and link with, a searchable database that helps researchers find immunologic reagents (commercial and non-commercial) known to cross-react with NHP targets.
What information is the database expected to help researchers find?
The database is intended to help researchers quickly determine which immunologic reagents cross-react with NHP targets, in which NHP species they work, for what application, and with what performance characteristics. The FOA frames this as a way to make cross-reactivity and validation information easier to locate.
How is this different from a typical research grant?
This is a cooperative agreement (U24), meaning NIH expects substantial involvement from the agency in steering or coordinating aspects of the effort. The FOA is oriented toward building and operating a community-facing resource rather than supporting a single-lab research project.
How many awards are expected?
The award structure indicates an expected single award.
What is the estimated total funding level for the FOA?
The FOA lists an estimated total funding level of $1,600,000.
Is there a cost sharing or matching requirement?
No. The information provided states there is no cost sharing or matching requirement listed.
What is the activity category and which CFDA numbers apply?
The activity category is Health. The relevant CFDA numbers listed are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Who is eligible to apply?
Eligibility is broad and includes many types of U.S.-based organizations, including: public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and non-501(c)(3)); small businesses; for-profit organizations other than small businesses; state and local governments (including city/township, county, special district); independent school districts; public housing authorities/Indian housing authorities; and tribal governments and organizations (including federally recognized tribes and other tribal entities). The FOA also explicitly includes various mission-focused institution types such as HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations, among others.
Are non-U.S. (foreign) organizations eligible to apply?
No. Non-U.S. (foreign) organizations and foreign institutions are not eligible to apply.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations are not eligible, based on the information provided.
Are foreign components allowed at all under this FOA?
Yes. The FOA notes that foreign components (as defined in the NIH Grants Policy Statement) are allowed, which generally means certain project elements may be carried out abroad when appropriately justified and permitted under NIH policy.
What research areas is this resource intended to support?
The FOA emphasizes enabling faster and more rigorous NHP-based immunology research, including work relevant to vaccine and adjuvant development and studies of infectious diseases and immune-mediated conditions, including transplantation.
How is the resource expected to help the broader research community?
By producing and distributing validated NHP immunologic reagents and by organizing and publishing cross-reactivity/validation information via a public website and searchable database, the program aims to reduce duplicated trial-and-error testing, improve comparability and reproducibility across studies, and speed progress in NHP-based biomedical research.
What are the key dates for this opportunity?
The FOA was posted/created on August 12, 2015. The original and current closing date was December 11, 2015. The archive date was January 11, 2016.
Where can applicants find the full announcement?
The full announcement was provided through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-15-038.html
Who is the agency behind this FOA?
The agency is the National Institutes of Health (NIH).
Who should be contacted for technical access issues related to the announcement?
For technical access issues, the contact listed is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
Since the FOA is archived, what does that imply about applying?
Based on the dates provided, the opportunity closed on December 11, 2015 and was archived on January 11, 2016. That indicates it was not an open, active solicitation as of the archive date.
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