Opportunity Information: Apply for RFA RM 15 009
Apply for RFA RM 15 009
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Jul 14, 2015 and posted on Jul 14, 2015.
- Applicants must submit their applications by Oct 15, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Private institutions of higher education City or township governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities County governments For profit organizations other than small businesses Independent school districts Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity titled "Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01)" is an NIH Common Fund cooperative agreement focused on pushing glycoscience into more mainstream biomedical research by lowering the practical barriers to working with carbohydrates (glycans). The core idea is that glycans play major roles in health and disease, but many labs avoid glycoscience because the methods can be specialized, expensive, and difficult to integrate into typical experimental workflows. This program, part of the Common Fund effort called Accelerating Translation of Glycoscience Integration and Accessibility, is intended to change that by supporting the creation of tools and technologies that are easier to adopt, more affordable, and broadly usable by researchers who are not glycoscience specialists.
This FOA specifically solicits projects that develop new or substantially improved tools, reagents, and technologies for four related needs: identifying glycans, tracking them in biological contexts, manipulating them experimentally, and analyzing glycans together with their biological binding partners to determine function. In practical terms, the NIH is looking for enabling technologies that make it simpler to connect glycan structure to biological activity, including how glycans interact with proteins or other binding partners, and how those interactions contribute to physiological or disease processes. The announcement also signals that proposed work can build on existing technologies and procedures, as long as the outcome meaningfully improves accessibility and usability for the broader community rather than only advancing a niche, highly specialized capability.
A notable emphasis is placed on translation and dissemination considerations, not just proof-of-concept performance. Applicants are expected, where applicable, to consider scale-up factors so that resulting instrumentation or methods can become broadly accessible and cost-effective for end users. This includes thinking ahead about manufacturing, robustness, ease of use, and practical cost constraints that often determine whether a tool becomes widely adopted. In addition, the FOA highlights the importance of data compatibility with existing databases, meaning the NIH wants outputs that can be integrated into current data resources and shared in standardized, interoperable ways. That reflects a broader goal of building community infrastructure: tools should not only generate results but should also fit into shared ecosystems for glycan-related data.
Administratively, this is a discretionary funding opportunity using the cooperative agreement mechanism (U01), which typically means NIH will have substantial scientific and/or programmatic involvement during the project period compared to a standard investigator-initiated grant. The opportunity is listed under the health activity category and carries CFDA number 93.310 (Trans-NIH Research Support). The FOA anticipated making about three awards, with an estimated total funding amount of about $2,000,000 and an award ceiling of $400,000. There is no cost-sharing or matching requirement indicated.
Eligibility is broad across U.S.-based organizations and governments, including public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and other nonprofit statuses), small businesses and other for-profit organizations (with small businesses explicitly listed), and various government entities such as state, county, city/township, special district governments, public housing authorities, and independent school districts. The eligibility language also explicitly includes several institution types that NIH often highlights, such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions, along with faith-based and community-based organizations and eligible federal agencies. Foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible; however, foreign components as defined in the NIH Grants Policy Statement are allowed, which generally means a U.S. applicant may include certain foreign collaborations or activities under NIH rules.
Key dates in the posted record show the announcement was posted and created on July 14, 2015, with an original and current closing date of October 15, 2015, and an archive date of November 15, 2015. The sponsoring agency is the National Institutes of Health, and the full announcement was made available through the NIH grants guide at the provided link. For access or technical issues, the contact point listed is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01)
What is the purpose of this funding opportunity?
This NIH Common Fund cooperative agreement (U01) supports the development of tools and technologies that make glycoscience easier to use in mainstream biomedical research. The overall goal is to lower practical barriers that keep many labs from working with glycans (carbohydrates), such as specialized methods, high costs, and workflows that are difficult to integrate into typical experiments.
What kinds of projects does the FOA solicit?
The FOA solicits projects that develop new or substantially improved tools, reagents, and technologies that help with: (1) identifying glycans, (2) tracking glycans in biological contexts, (3) manipulating glycans experimentally, and (4) analyzing glycans together with their biological binding partners to determine function.
What does "identify glycans" mean in the context of this opportunity?
Based on the FOA description, "identify" refers to tools that enable researchers to determine glycan structures more readily and connect those structures to biological questions, with an emphasis on lowering barriers for non-specialists.
What does "track glycans" mean here?
"Tracking" refers to technologies that allow glycans to be followed in biological contexts. The FOA frames this as an enabling capability that helps connect glycan structure and behavior to biological activity in health and disease.
What does "manipulate glycans" mean for proposed tools?
"Manipulation" refers to experimental methods or reagents that let researchers alter glycans in a controlled way to test how changes in glycans affect biological systems. The FOA emphasizes that these capabilities should be more accessible and usable for the broader biomedical community.
What does it mean to analyze glycans with their binding partners to determine function?
The FOA specifically highlights the need to analyze glycans together with biological binding partners (such as proteins or other binding partners) to determine function. In practical terms, NIH is seeking tools that make it easier to connect glycan structure to biological interactions and to understand how those interactions contribute to physiology or disease processes.
Does the FOA allow building on existing technologies?
Yes. The FOA states that proposed work can build on existing technologies and procedures, as long as the result meaningfully improves accessibility and usability for the broader community rather than only advancing a niche, highly specialized capability.
What is the main emphasis beyond proof-of-concept performance?
A notable emphasis is on translation and dissemination considerations. Applicants are expected, where applicable, to consider scale-up so that instrumentation or methods can become broadly accessible and cost-effective for end users. The FOA points to factors like manufacturing, robustness, ease of use, and practical cost constraints that influence whether a tool becomes widely adopted.
What does the FOA say about data standards or database compatibility?
The FOA highlights the importance of data compatibility with existing databases. NIH wants outputs that can be integrated into current data resources and shared in standardized, interoperable ways, supporting broader community infrastructure for glycan-related data.
What funding mechanism is used?
This opportunity uses the NIH cooperative agreement mechanism (U01). The FOA notes that this typically means NIH will have substantial scientific and/or programmatic involvement during the project period compared to a standard investigator-initiated grant.
Which NIH effort or program is this associated with?
It is part of an NIH Common Fund effort described as Accelerating Translation of Glycoscience Integration and Accessibility, intended to push glycoscience into more mainstream biomedical research by lowering practical barriers.
How many awards are anticipated?
The FOA anticipated making about three awards.
What is the estimated total funding amount?
The estimated total funding amount is about $2,000,000.
What is the award ceiling?
The posted record lists an award ceiling of $400,000.
Is cost sharing or matching required?
No. The information provided indicates there is no cost-sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and governments. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and other nonprofit statuses), small businesses and other for-profit organizations (with small businesses explicitly listed), and many types of government entities (state, county, city/township, special district governments, public housing authorities, and independent school districts). The FOA also explicitly includes institution types NIH often highlights, such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions, as well as faith-based and community-based organizations and eligible federal agencies.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply.
Can a U.S. applicant include foreign collaborations or work?
Yes, with limits. Non-domestic components of U.S. organizations are not eligible, but foreign components (as defined in the NIH Grants Policy Statement) are allowed. This generally means a U.S. applicant may include certain foreign collaborations or activities under NIH rules.
What is the health activity category and CFDA number?
The opportunity is listed under the health activity category and carries CFDA number 93.310 (Trans-NIH Research Support).
When was this opportunity posted and when did it close?
The posted record shows the announcement was posted/created on July 14, 2015. The original and current closing date is October 15, 2015, and the archive date is November 15, 2015.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
Where was the full announcement made available?
The full announcement was made available through the NIH grants guide at the provided link in the posting.
Who should be contacted for access or technical issues?
For access or technical issues, the contact listed is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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